A5037246864- Botulinum Toxin and Related Neurological Disorders
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Legionella and Acanthamoeba research
- Fungal Infections and Studies
- Facial Trauma and Fracture Management
- Vibrio bacteria research studies
- Reconstructive Surgery and Microvascular Techniques
- Hepatitis Viruses Studies and Epidemiology
- Pain Mechanisms and Treatments
- Bacterial biofilms and quorum sensing
- Listeria monocytogenes in Food Safety
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Periodontal Regeneration and Treatments
- Indoor Air Quality and Microbial Exposure
- Oral and Maxillofacial Pathology
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Otolaryngology and Infectious Diseases
- Infections and bacterial resistance
- Bacillus and Francisella bacterial research
- Pulmonary Hypertension Research and Treatments
- Bacterial Identification and Susceptibility Testing
California Department of Public Health
2012-2024
Centers for Disease Control and Prevention
2024
Franciscan Health
2024
Monterey County Health Department
2024
United States Geological Survey
2023
Napa State Hospital
2023
California Department of Parks and Recreation
2023
National Park Service
2023
Bureau of Land Management
2023
Environmental Protection Agency
2023
High prevalences of HIV and other sexually transmitted infections (STIs) have been reported in the current global monkeypox outbreak, which has affected primarily gay, bisexual, men who sex with (MSM) (1-5). In previous outbreaks Nigeria, concurrent infection was associated poor clinical outcomes (6,7). Monkeypox, HIV, STI surveillance data from eight U.S. jurisdictions* were matched analyzed to examine diagnoses among persons assess differences features according status. Among 1,969 during...
Peroxisomes are organelles that perform a wide range of metabolic functions in eukaryotic cells. However, their role fungal pathogenesis is poorly understood. Here we report ClaPEX6, an ortholog PEX6, required for the fungus Colletotrichum lagenarium to infect host plants. ClaPEX6 was identified random insertional mutagenesis experiments aimed at elucidating genes involved pathogenesis. Functional analysis, using green fluorescent protein cassette containing peroxisomal targeting signal1...
In California, black tar heroin (BTH) use among injection drug users (IDUs) has resulted in an increased number of cases wound botulism due to Clostridium botulinum, tetanus tetani, and necrotizing soft-tissue infections a variety clostridia. From December 1999 April 2000, nine IDUs Ventura County, developed fasciitis; 4 died. Cultures specimens from 6 case patients yielded sordellii. Some the appeared have toxic shock syndrome previously reported be characteristic toxin-mediated C....
ABSTRACT The in vitro and vivo antifungal activities of T-2307, a novel arylamidine, were evaluated compared with those fluconazole, voriconazole, micafungin, amphotericin B. T-2307 exhibited broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans 0.0039 0.0625 Aspergillus 0.0156 4 μg/ml). Furthermore, potent fluconazole-resistant fluconazole-susceptible-dose-dependent albicans strains as well...
T-2307, a novel arylamidine, has been shown to exhibit broad-spectrum antifungal activities against clinically significant pathogens. Here, we evaluated the in vitro and vivo antimalarial activity of T-2307. The 50% inhibitory concentrations (IC₅₀s) T-2307 Plasmodium falciparum FCR-3 K-1 strains were 0.47 0.17 μM, respectively. at 2.5 10 mg/kg body weight/day exhibited blood stage liver parasites rodent malaria models. In conclusion, activity.
T-2307, an arylamidine compound, has been previously reported to have broad-spectrum in vitro and vivo antifungal activities against clinically significant pathogens, including Candida species, Cryptococcus neoformans, Aspergillus is now undergoing clinical trials. Here we investigated the mechanism of action T-2307 using yeast cells mitochondria isolated from rat liver. Nonfermentative growth albicans Saccharomyces cerevisiae glycerol medium, which yeasts relied on mitochondrial respiratory...
7-Methylguanosine (m7G) modification of tRNA occurs widely in prokaryotes and eukaryotes, although information about its biological roles is limited. Here, we report that a gene involved m7G required for infection by the phytopathogenic fungus Colletotrichum lagenarium. Analysis infection-deficient mutant C. lagenarium, produced plasmid insertional mutagenesis, identified tagged designated APH1. The aph1 mutants, generated targeted disruption, exhibit significant reduction pathogenicity on...
Background: Ralstonia pickettii is a Gram-negative bacillus commonly found in soil and moist environments; however, R. rarely isolated from clinical specimens. In August 2001, cluster of bacteremia occurred among neonatal intensive care unit (NICU) infants at California hospital. Methods: A case-control study was conducted to determine risk factors for infection. case NICU patient with bacteremia. Controls were negative blood cultures drawn during the same time period. detailed environmental...
Abstract Serratia marcescens is an environmental gram-negative bacterium that causes invasive disease in rare cases. During 2020–2022, outbreak of 21 infections occurred a prison California, USA. Most (95%) patients had history recent injection drug use (IDU). We performed whole-genome sequencing and found isolates from 8 2 pieces IDU equipment were closely related. also identified social interactions among patients. recovered S. multiple samples throughout the prison, including personal...
During September 29-October 6, 2017, the County of San Diego Public Health Services (COSD) was notified two patients with suspected wound botulism and a history using black tar heroin. On October 9, COSD, which had reported an average one case per year during 2001-2016, sent health alert through California Alert Network, notifying Southern providers these patients, including their signs symptoms heroin exposure. In collaboration Department Health, COSD conducted investigation to identify...
The purpose of this study was to investigate the dynamic effect maxillary reconstruction after partial resection maxilla.On a personal computer, three-dimensional maxilla models were designed based on computed tomographic data obtained from 10 edentulous skull models. Simulation surgery performed each model, creating pairs half-removed and corresponding with rib. three different patterns seen in termed normal maxilla, reconstructed maxilla. After an implant fixed molar region 300-N vertical...
Platelets, which contain many growth factors, such as platelet-derived factor (PDGF) and transforming factor-beta(TGF-beta), can be obtained in high concentrations by centrifugal separation are being used platelet-rich plasma (PRP) clinical applications. The authors evaluated the bone formation ability PRP rabbits.In experiment 1, made platelet precipitations from whole blood rabbits. Each precipitated was resuspended fibrin glue. glue applied to a 1-mm wide slit defect of same rabbit...
The purpose of this study is to determine the most stable fixation method for mandibular symphysis fractures by comparing mechanical characteristics models fixed at different positions with numbers plates. Fractures were generated in 3-dimensional finite element models, and a single miniplate, parallel double miniplates, or perpendicular miniplates. A 300 N load was then applied on left molar region, analysis performed. We compared vertical gaps between fractured surfaces, maximum stress...
Abstract Background Botulism is a rare and potentially fatal paralytic disease caused by botulinum neurotoxin (BoNT). In April 2017, 4 California residents from 2 adjacent counties were hospitalized with suspected foodborne botulism, precipitating an investigation state local public health departments in California. Methods We interviewed botulism patients their families, inspected the suspect establishment, collected food. tested patient sera, stool, gastric aspirates using mouse bioassay...
Abstract We investigated a multistate cluster of Escherichia coli O157:H7 isolates; pulsed-field gel electrophoresis subtyping, using single enzyme, suggested an epidemiologic association. An investigation and additional however, did not support the Confirmation E. O157 clusters with two or more restriction endonucleases is necessary before public health resources are allocated to follow-up investigations.
Abstract Background In 2017, local public health authorities in California received reports of 2 elderly patients with suspected botulism who knew each other socially. A multijurisdictional investigation was conducted to determine the source. Methods Investigators reviewed medical records, interviewed family establish food and drink histories, inspected a facility that produced liquid herbal tea. Clinical specimens product were tested for botulinum neurotoxin (BoNT). Results total confirmed...
Abstract: Although cryptococcosis is a common thoracic complication among patients with AIDS, endobronchial abnormalities have rarely been reported. A 45‐year‐old man presented productive cough, fever, and headache. His CD4+ cell count was 7/mm 3 testing for antibodies to HIV‐1 positive. Radiological examination revealed consolidation in the left lung, including cavitation. Bronchoscopic demonstrated white, slightly raised, plaque‐like lesions trachea bronchi. Histopathological of biopsy...