A5082495113- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Dental Erosion and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Dental Health and Care Utilization
- Dental Radiography and Imaging
- Insect Utilization and Effects
- MicroRNA in disease regulation
- Animal and Plant Science Education
- Dental Research and COVID-19
- Artificial Intelligence in Healthcare and Education
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
- Genomic variations and chromosomal abnormalities
- Dietetics, Nutrition, and Education
- Social Media in Health Education
- Intracerebral and Subarachnoid Hemorrhage Research
- Rheumatoid Arthritis Research and Therapies
- Genetic Syndromes and Imprinting
- Scientific and Engineering Research Topics
- ATP Synthase and ATPases Research
- Oral health in cancer treatment
- 14-3-3 protein interactions
Charité - Universitätsmedizin Berlin
2003-2023
Humboldt-Universität zu Berlin
1987-2018
Freie Universität Berlin
2018
Glostrup Hospital
2015-2017
Rigshospitalet
2017
University of Copenhagen
2014-2016
RWTH Aachen University
2015
Leipzig University
2011
University of Leeds
2010
The University of Queensland
2006
Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We combined vitro vivo approaches to test possible GHSR-mediated of dAG. Both AG (100 nmol/L) dAG significantly increased inositol triphosphate formation human embryonic kidney-293 cells transfected with GHSR. As expected, intracerebroventricular...
This paper discusses the current state and priorities of Europe-based research on insects as food feed, based presentations at a workshop held in December 2015, discussions that followed. We divide into studies focus farming, health nutrition, those prioritise psychological, social political concerns. Edible are not necessarily universally beneficial. However, certain can convert organic waste material, provide nutrient-rich protein for humans animals. Recent is concordant when trying to...
Functional coupling occurs between PEN-GPR83 and bigLEN-GPR171, ligand-receptor pairs implicated in feeding.
miRNAs are small 22-nucleotide RNAs that can post-transcriptionally regulate gene expression. It has been proposed dietary plant enter the human bloodstream and host transcripts; however, these findings have widely disputed. We here conduct first comprehensive meta-study in field, surveying presence abundances of cross-species (xenomiRs) 824 sequencing data sets from various tissues body fluids. find xenomiRs commonly present (17%) fluids (69%); low, comprising 0.001% miRNA counts. Further,...
The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 regulated response to nutrient availability and decreased obese mice compared with lean mice. In the arcuate nucleus, colocalizes ghrelin (Ghsr1a) agouti-related protein. vitro analyses show heterodimerization Ghsr1a diminishes activation by acyl-ghrelin. orexigenic adipogenic effect accordingly potentiated Gpr83-deficient...
Edible insects are being framed as a panacea for health, resource and climate challenges, the ‘entomophagy movement’ is growing rapidly. Yet insect ‘solution’ scaled up, there greater focus on technical innovation less structural inequalities that govern who produces within, controls, benefits from edible trade. We ask: To what extent promotion of ‘entomophagy’ challenging or reproducing power relations in global food systems? Drawing evidence academia, industry, local trade Southeast Asia...
Objective The melanocortin receptor accessory protein 2 (MRAP2) is relevant for weight regulation in mice and humans. This function likely mediated by of the melanocortin‐4 (MC4R). Functional implications human MRAP2 mutations have not been described yet. Methods A mutation screen was conducted 184 children adolescents with (extreme) obesity lean controls. Detected nonsynonymous variants were genotyped larger independent study groups (300 people 436 individuals normal weight). influence...
Most in vivo effects of 3-iodothyronamine (3-T1AM) have been thus far thought to be mediated by binding at the trace amine-associated receptor 1 (TAAR1). Inconsistently, 3-T1AM-induced hypothermic effect still persists Taar1 knockout mice, which suggests additional targets. In support this general assumption, it has previously reported that 3-T1AM also binds α-2A-adrenergic (ADRA2A), modulates insulin secretion. However, mechanism remains unclear. We tested two different scenarios may...
The present study aimed to identify barriers and enablers for the implementation of artificial intelligence (AI) in dental, specifically radiographic, diagnostics. Semi-structured phone interviews with dentists patients were conducted between end May June 2020 (convenience/snowball sampling). A questionnaire developed along Theoretical Domains Framework (TDF) Capabilities, Opportunities Motivations influencing Behaviors model (COM-B) was used guide interviews. Mayring’s content analysis...
Background: The aim of our study was to evaluate the between-assay variability commercially available immunoassays for measurement human growth hormone (hGH). In addition, we asked whether comparability diagnosis childhood onset deficiency could be improved by adjusting hGH results statistical methods, such as linear regression, conversion factors, and quantile transformation.
The G-protein coupled receptor 83 (GPR83) is an orphan for which the natural ligand(s) and signaling pathway(s) remain to be identified. Previous studies suggest a role of GPR83 in regulation thermogenesis control circulating adiponectin. aim this study was gain insights into molecular underpinnings underlying signaling. In particular, we aimed assess activated pathway how affected by mutational activation zinc(II) challenge. Finally, assessed capacity homodimerization. Our results show...
Obesity is one of the most challenging global health problems. One key player in energy homeostasis melanocortin-4 receptor (MC4R), which a family A G-protein-coupled (GPCR). It has recently been shown that MC4R capacity to form homo- or heterodimers. Dimerization GPCRs great importance for signaling regulation, with major pharmacological implications. Unfortunately, not enough yet known about detailed structural properties dimers functional consequences dimerization. Our goal, therefore,...
Honeybee ( Apis mellifera ) brood is enjoyed as food in many regions of the world. The Nordic region Europe not currently one them, but it could be. drone particular constitute an untapped source delicious, nutritious and potentially sustainable food. Currently, removed by beekeepers part a strategy to lower population destructive Varroa mite destructor hive, most often disposed of. A descriptive sensory analysis was conducted, using larvae pupae from four hives, three Denmark Norway,...
microRNAs (miRNAs) are important regulators of translation and have been implicated in the pathogenesis a number cardiovascular diseases, including stroke, suggested as possible prognostic biomarkers. Our aim was to identify miRNAs that differentially regulated cerebral arteries after subarachnoid hemorrhage (SAH), using rat injection model SAH qPCR-based screen 728 miRNAs. Additionally, serum analyzed for spill-over circulation from vessel walls.We identified 482 different expressed...
The murine G-protein coupled receptor 83 (mGPR83) is expressed in the hypothalamus and was previously suggested to be involved regulation of metabolism. neuropeptide PEN has been recently identified as a potent GPR83 ligand. Moreover, constitutes functionally relevant hetero-oligomers with other receptors (GPCR) such ghrelin (GHSR) or GPR171. Previous deletion studies also revealed that long N-terminal extracellular domain (eNDo) mGPR83 may act an intra-molecular ligand, which participates...
This study compared survival, restoration quality and costs of glass hybrid (GH; EQUIA Forte Fil/EQUIA Coat) resin composite restorations (RC; OptiBond FL/Filtek Supreme XTE) sclerotic non-carious cervical lesions.This is a cluster-randomized trial (ClinicalTrials.gov: NCT02631161). 88 patients (50-70 years) with 175 sNCCLs were randomized to receive GH or RC. Restorations placed without mechanical cavity preparation followed for mean 36 (min/max: 31/55) months (variable follow-up due...
Objectives To assess possible health policy interventions derived from the theoretical domains framework (TDF) by studying barriers and facilitators on delivery of oral healthcare hygiene in German care homes using a behavioural change framework. Design Qualitative correlational study to evaluate national intervention programme. Setting Primary two rural Germany. Participants Eleven stakeholders participating (hygiene, treatment) older people, including home managers, four section...
Molecular mechanisms behind increased cerebral vasospasm and local inflammation in late ischemia after subarachnoid hemorrhage (SAH) are poorly elucidated. Using system biology tools experimental SAH models, we have identified signal transducer activator of transcription 3 (STAT3) factor as a possible major regulatory molecule. On the basis presence binding sequence promoters differentially regulated genes (significant enrichment PE: 6 × 10 5 ) consistent expression STAT3 (mRNA, P = 0.0159...