A5070473796- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Microplastics and Plastic Pollution
- Environmental Toxicology and Ecotoxicology
- Recycling and Waste Management Techniques
- Animal testing and alternatives
- Nanoparticles: synthesis and applications
- Receptor Mechanisms and Signaling
- Advanced Nanomaterials in Catalysis
- Analytical chemistry methods development
- Health and Medical Research Impacts
- Parasite Biology and Host Interactions
- Geochemistry and Elemental Analysis
- Water Quality Monitoring and Analysis
- Olfactory and Sensory Function Studies
- Advanced oxidation water treatment
- Environmental remediation with nanomaterials
- Innovations in Medical Education
- Mosquito-borne diseases and control
- Biopolymer Synthesis and Applications
- Advanced Chemical Sensor Technologies
- Toxic Organic Pollutants Impact
- Enzyme-mediated dye degradation
- Subterranean biodiversity and taxonomy
- Insect Pest Control Strategies
Norwegian University of Science and Technology
2019-2024
Goethe University Frankfurt
2013-2019
Plastics are complex chemical mixtures of polymers and various intentionally nonintentionally added substances. Despite the well-established links between certain plastic chemicals (bisphenols phthalates) adverse health effects, composition toxicity real-world not well understood. To assess both, we analyzed from 36 food contact articles five countries using nontarget high-resolution mass spectrometry reporter-gene assays for four nuclear receptors that represent key components endocrine...
Microplastics (MP) are contaminants of emerging concern in aquatic ecosystems. While the number studies is rapidly increasing, a comparison toxicity MP and natural particulate matter largely missing. In addition, research focusses on impacts hydrophobic chemicals sorbed to plastics. However, interactive effects hydrophilic, dissolved remain unknown. Therefore, we conducted chronic with larvae freshwater dipteran Chironomus riparius exposed unplasticised polyvinyl chloride (PVC-MP) as well...
Abstract Throughout the past decade, many studies have reported adverse effects in biota following microplastic exposure. Yet, field is still emerging as current understanding of toxicity limited. At same time, recent legislative mandates required environmental regulators to devise strategies mitigate pollution and develop health-based thresholds for protection human ecosystem health. The publication rate also presents a unique challenge scientists, managers, other communities may find it...
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity cell animal models. However, these well-known metabolism-disrupting (MDCs) represent only a minute fraction of all compounds found plastics. To gain comprehensive understanding plastics as source exposure to MDCs, we characterized the present 34 everyday products using nontarget high-resolution mass spectrometry analyzed their joint adipogenic activities by high-content imaging. We detected 55,300...
G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field toxicology. Herein, we investigated these as novel targets plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In first-pass screen, tested activity triphenol phosphate, bisphenol A, diethyl phthalate, well three real-world mixtures extracted from food...
Plastics constitute a vast array of substances, with over 16 000 known plastic chemicals, including intentionally and non-intentionally added substances. Thousands toxic ones, are extractable from plastics, however, the extent to which these compounds migrate everyday products into food or water remains poorly understood. This study aims characterize endocrine metabolism disrupting activity, as well chemical composition migrates contact articles (FCAs) four countries significant sources...
Conventional activated sludge treatment of wastewater does not completely remove micropollutants. Here, extending anaerobic conditions may enhance biodegradation. To explore this, we combined iron-reducing or substrate-limiting and aerobic pilot-scale reactors directly at a plant. assess the removal endocrine disrupting chemicals (EDCs) as group micropollutants that adversely affects wildlife, applied bioanalytical approach. We used in vitro bioassays covering seven receptor-mediated...
The 3T3-L1 murine pre-adipocyte line is an established cell culture model for screening Metabolism Disrupting Chemicals (MDCs). Despite a need to accurately identify MDCs further evaluation, relatively little research has been performed comprehensively evaluate reproducibility across laboratories, assess factors that might contribute varying degrees of differentiation between laboratories (media additives, plastics, source, etc.), or standardize protocols. As such, the goals this study were...
Ecological speciation assumes reproductive isolation to be the product of ecologically based divergent selection. Beside natural selection, sexual selection via phenotype-assortative mating is thought promote isolation. Using neotropical fish Poecilia mexicana from a system that has been described undergo incipient ecological in adjacent, but habitats characterized by presence or absence toxic H 2 S and darkness cave habitats, we demonstrate gradual change male body colouration along...
The Asian tiger mosquito Aedes albopictus (Skuse, 1894) is a globally invasive prominent vector of viral and parasitic pathogens. To soundly guide insecticide use in control programs it crucial to standardized test systems under rigorously controlled environmental conditions that allow for comparisons across laboratories. An acute standard procedure (24 h) resistance monitoring mosquitoes has been published by the World Health Organization 1998, but chronic monitor sublethal effects on life...
ABSTRACT Plastics are complex chemical mixtures of polymers and various intentionally non-intentionally added substances. Despite the well-established links between certain plastic chemicals (bisphenols, phthalates) adverse health effects, composition toxicity real-world is not well understood. To assess both, we analyzed from 36 food contact articles five countries using nontarget high-resolution mass spectrometry reporter gene assays for four nuclear receptors that represent key components...
ABSTRACT Plastics constitute a vast array of substances, with over 16 000 known plastic chemicals, including intentionally and non-intentionally added substances. Toxicity thousands chemicals are extractable from plastics; however, the extent to which toxicity migrate everyday products remains poorly understood. This study aims characterize endocrine metabolism disrupting activity, as well chemical composition migrates food contact articles (FCAs) four countries significant sources human...
Ärzte, die klinisch und wissenschaftlich tätig sind, sind essenziell, um Fortschritte in der modernen Medizin zu erreichen. Trotzdem nimmt ihre Anzahl stetig ab. Gerade chirurgischen Fächern scheint Vereinbarkeit von Klinik Forschung oft unmöglich. Immer mehr Universitätskliniken bieten nun sogenannte Clinician-Scientist-Programme an, bei denen AssistenzärtzInnen Möglichkeit bekommen, klinische wissenschaftliche Tätigkeiten kombinieren.
Abstract Figure G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field toxicology. Herein, we investigated these novel targets plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In first-pass screen, tested activity triphenol phosphate, bisphenol A, diethyl phthalate as well three real-world mixtures extracted...