A5101825097- Cardiovascular Conditions and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Congenital heart defects research
- Veterinary Orthopedics and Neurology
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Potassium and Related Disorders
- Pharmacological Effects and Assays
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- melanin and skin pigmentation
- Connective tissue disorders research
- MicroRNA in disease regulation
- Hip disorders and treatments
- Animal Nutrition and Physiology
- Neurogenetic and Muscular Disorders Research
- Parasites and Host Interactions
- Muscle Physiology and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Dermatological diseases and infestations
- Regulation of Appetite and Obesity
- Genetic Associations and Epidemiology
Auburn University
2015-2024
Veterinary Medical Teaching Hospital
2011-2012
University of California, Davis
2011-2012
Cornell University
2008-2011
Chosun University
2011
The prevalence and prognostic importance of atrial fibrillation (AF) on survival in nonsmall breed dogs with myxomatous mitral valvular disease (MMVD) congestive heart failure (CHF) remain unknown.To identify the AF CHF because MMVD to characterize impact outcome.Sixty-four client-owned (>15 kg) CHF.Retrospective review medical records for weighing >15 kg treated CHF.Thirty-three presented or developed during follow-up examinations, 31 were free until cardiac-related death. For AF, median...
To determine whether a mutation in the fibrillin 2 gene (FBN2) is associated with canine hip dysplasia (CHD) and osteoarthritis dogs.1,551 dogs. Procedures-Hip conformation was measured radiographically. The FBN2 sequenced from genomic DNA of 21 Labrador Retrievers Greyhounds, haplotype intron 30 90 additional 143 dogs 6 other breeds. Steady-state values mRNA control genes were joint tissues fourteen 8-month-old Retriever-Greyhound crossbreeds.The homozygous for 10-bp deletion had...
OBJECTIVE To characterize expression profiles of circulating microRNAs via genome-wide sequencing for dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve degeneration (MMVD). ANIMALS 9 healthy client-owned and 8 age-matched CHF MMVD. PROCEDURES Blood samples were collected before administering cardiac medications the management CHF. Isolated from plasma classified into microRNA libraries subjected next-generation (NGS) analysis quantification microRNAs. Quantitative...
Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines.
Atenolol often is used empirically in cats with hypertrophic cardiomyopathy (HCM) before the onset of heart failure, although evidence efficacy lacking. Cardiac biomarkers play a critical role early detection subclinical cardiac disease, prediction long-term prognosis, and monitoring response to therapy humans.Circulating concentrations N-terminal pro-B type natriuretic peptide (NT-proBNP) troponin I (cTnI) will decrease after chronic administration atenolol PO severe HCM but no signs...
555X Fig. 1.Right parasternal short axis echocardiogram showing the right ventricular outflow tract (RVOT) and main pulmonary artery (PA).(A) The supravalvular lesion (yellow arrowhead) is distal to valve (blue arrow).(B) Color flow Doppler ultrasound shows turbulence originating at level of stenosis.
The dark-like (dal) mutant mouse has a pleiotropic phenotype that includes dark dorsal hairs and reproductive degeneration. Their pigmentation is similar to Attractin (Atrn) mutants, which also develop vacuoles throughout the brain. In further characterizing testicular degeneration of dal males, we found they had reduced serum testosterone developed in their testes. Genetic crosses placed upstream melanocortin 1 receptor (Mc1r) downstream agouti, although suppressed effect agouti on but not...
The present study was designed to identify regional cerebral blood flow (rCBF) abnormalities in systemic lupus erythematosus (SLE) patients with memory impairments. Nineteen SLE (mean age 36.1 ± 8.6 years, range 17–47) subjective complaints underwent brain single-photon emission computed tomography (SPECT). Korean Wechsler Adult Intelligence Scale (K-WAIS) and the Rey–Kim Memory Test (RKMT) were used objectively evaluate cognitive functions these patients. On basis of Quotient–Memory...
Background The effects of sacubitril/valsartan (S/V) on the renin‐angiotensin‐aldosterone system (RAAS) in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD) are currently unknown. Objectives To determine pharmacodynamic S/V RAAS, natriuretic peptide concentrations, systolic arterial pressure (SAP), tests renal function, and serum electrolyte concentrations MMVD. Animals Thirteen client‐owned weighing 4‐15 kg American College Veterinary Internal Medicine (ACVIM) Stage...
BACKGROUND Hypertrophic cardiomyopathy, characterized by thickened ventricular walls and reduced chamber volume, is a common cause of sudden cardiac death in young people. Most inherited forms result from mutations genes encoding sarcomeric proteins. METHODS Histologic analysis identified embryonic hypertrophy dark-like mutant mice. BrdU was performed to measure proliferation cardiomyocytes were isolated cell size. The mutation positional cloning. RESULTS causes cardiomyocyte due...
To demonstrate a critical role of artificial cardiac pacing to normalize severe bradyarrhythmia-induced hyperkalemia in dog with third-degree atrioventricular (AV) block.A was presented for evaluation and bradyarrhythmia. ECG revealed AV block heart rate 10-20 min, which lower than usual ventricular escape rate. The etiology considered secondary significantly decreased renal perfusion potassium excretion as result poor output caused by the block. Since disorders may lead life-threatening...
In this case report, a high dose of torsemide (6mg/kg, every 12 hours for 3 days followed by 12mg/kg, 4 days) was administered orally to horse with congestive heart failure (CHF) and atrial fibrillation. Blood samples measurement plasma concentrations were obtained one hour after each drug administration. Pharmacodynamic effects oral evaluated daily physical examination, electrocardiography, serum biochemistry. The tolerated administration torsemide. A decrease in ventral oedema venous...