A5029902902- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Peroxisome Proliferator-Activated Receptors
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Disease and Adiposity
- Advanced Glycation End Products research
- Signaling Pathways in Disease
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Antioxidant Activity and Oxidative Stress
- Cancer survivorship and care
- Metabolism and Genetic Disorders
- Cardiac Imaging and Diagnostics
- Hemophilia Treatment and Research
- Diabetes and associated disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
Policlinico Umberto I
2020-2025
University of Naples Federico II
2003-2016
National Institute on Aging
2009
National Institutes of Health
2009
May Institute
2009
Indian Immunologicals (India)
2008
Inflammation plays a pivotal role in atherothrombosis. In addition to being prognostic marker for major cardiovascular events, recent data indicate that C-reactive protein (CRP) might directly promote atherothrombosis by exerting direct effects on vascular cells. The aim of the present study was determine whether CRP affect prothrombotic and proliferative characteristics endothelial (ECs) smooth muscle cells (SMCs).Incubation ECs SMCs with resulted dose-dependent activation cell...
To investigate the effects of exercise training (ET) on left ventricular (LV) volumes, cardiopulmonary functional capacity and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in postinfarction patients with moderate LV dysfunction. Sixty-one were randomized into two groups: group T [n = 30, ejection fraction (EF) 41.6 ± 11.3%, mean SD] entered a 6-month ET programme, whereas C (n 31, EF 42.0 7.6%, P=NS) did not. NT-proBNP assay, Doppler-echocardiography test performed upon...
<i>Objective:</i> Atherosclerosis is characterized by endothelial inflammation and dysfunction. Adipose tissue has increasingly been recognized as an active endocrine organ secreting so-called adipokines. Among these, resistin – recently described, but not yet extensively studied defined a novel inflammatory marker in atherosclerosis. The pathophysiology underlying this interplay, however, remains to be fully characterized. aim of the study determine whether might affect...
Tissue factor (TF) is the main initiator of coagulation in vivo. Recently, however, a role for TF as cell receptor involved signal transduction has been suggested. The aim present study was to assess whether activated VII (FVIIa) binding could induce smooth muscle (SMC) proliferation and clarify possible intracellular mechanism(s) responsible this proliferation.Cell induced by FVIIa dose-dependent manner, assessed [3H]thymidine incorporation direct counting, whereas no response observed with...
<i>Background:</i> Obesity and cardiovascular disease are closely related. Leptin, an adipocyte-produced hormone, is associated with increased risk. Increased plasma levels of leptin measurable in the obese individuals. However, possible links between obesity not completely understood. C-reactive protein (CRP) a predictor future events plays role atherothrombotic disease. Thus, we evaluated whether might play disease, investigating its effects on CRP production by human coronary...
Heart rate recovery (HRR) is a marker of vagal tone, which powerful predictor mortality in patients with cardiovascular disease. Sacubitril/valsartan (S/V) treatment for heart failure reduced ejection fraction (HFrEF), impressively impacts outcome. This study aims at evaluating the effects S/V on HRR and its correlation cardiopulmonary indexes HFrEF patients.Patients admitted to outpatients' services were screened out inclusion. was administered according guidelines. Up-titration performed...
atherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that particles (very (VLDL), intermediate-density (IDL)), could contribute to residual risk. The present study aims investigate the relationship between carotid intima-media thickness (IMT) and different subfractions a cohort of healthy postmenopausal women.75 women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical...
Smoking predisposes to the development of atherosclerosis and its complications. The mechanisms responsible for these effects are not completely understood. We have investigated whether nicotine might promote a proatherosclerotic state in human coronary endothelial cells (HCAECs), studying role 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors preventing phenomena.Real-time PCR showed that induced dose-dependent increase mRNA levels vascular cellular adhesion molecule-1...
Background andObjectives: Current guidelines on cardiac rehabilitation (CR) suggest moderate-intensity physical activity after acute coronary syndrome (ACS). Recent report have shown that high-intensity interval training (HIIT) could be more effective than continuous (MCT) in improving performance. Our aim was to analyze the effects of HIIT protocol ACS advanced echocardiographic parameters myocardial function. Materials and Methods: In total, 75 patients with recent ACS, or without ST...
Iron deficiency anemia (IDA) is frequent after cardiac surgery and associated with increased morbidity mortality. In a retrospective study, we analyzed 106 patients IDA (hemoglobin [Hb] ≤ 12 g/dl in women 13 men, transferrin saturation [TSAT] 20%) on admission to Cardiac Rehabilitation Unit surgery. The were divided into two groups, one was treated oral sucrosomial iron (SI) the other intravenous ferric carboxymaltose (FCM). Patients received single 1000 mg dose of FCM from day...