A5071297836- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Historical and Environmental Studies
- Cardiac Valve Diseases and Treatments
- Diverse academic and cultural studies
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Natural Fiber Reinforced Composites
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- finance, banking, and market dynamics
- Amyotrophic Lateral Sclerosis Research
- Apelin-related biomedical research
- Cholinesterase and Neurodegenerative Diseases
Ospedale Vincenzo Cervello
2020-2024
Fondazione Santa Lucia
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
Ospedale Buccheri la Ferla Fatebenefratelli
2015-2023
Fatebenefratelli Hospital
2015-2023
Centro Cardiologico Monzino
2022
Ospedale Monaldi
2021
University of Campania "Luigi Vanvitelli"
2021
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2014-2017
Tunisia Polytechnic School
2016
Background. Sacubitril/valsartan in heart failure (HF) with reduced ejection fraction (HFrEF) was shown to be superior enalapril reducing the risk of death and hospitalization for HF. Our aim evaluate cardiopulmonary effects sacubitril/valsartan patients HFrEF. Methods. We conducted an observational study. Ninety-nine ambulatory HFrEF underwent serial exercise tests (CPET) after initiation addition recommended therapy. Results. At baseline, 37% had New York Heart Association (NYHA) class...
Several mutations in the SOD1 gene encoding for antioxidant enzyme Superoxide Dismutase 1, are associated with amyotrophic lateral sclerosis, a rare and devastating disease characterized by motor neuron degeneration patients' death within 2–5 years from diagnosis. Motor loss related symptomatology manifest mostly adult life and, to date, there is still gap of knowledge on precise cellular molecular events preceding neurodegeneration. To deepen our awareness early phases disease, we leveraged...
Abstract Aims Ventilation vs. carbon dioxide production (VE/VCO 2 ) is among the strongest cardiopulmonary exercise testing prognostic parameters in heart failure (HF). It usually reported as an absolute value. The current definition of normal VE/VCO slope values inadequate, since it was built from small groups subjects with a particularly limited number women and elderly. We aimed to define prediction formulas sizable population test whether power HF different if expressed percentage...
Sacubitril/valsartan has been shown to be superior enalapril in reducing the risks of death and hospitalization for heart failure (HF). However, knowledge impact on cardiac performance remains limited. We sought evaluate effects sacubitril/valsartan clinical, biochemical echocardiographic parameters patients with reduced ejection fraction (HFrEF).Sacubitril/valsartan was administered 205 HFrEF patients.Among 230 (mean age 59 ± 10 years, 46% ischemic disease) (89%) completed study. After a...
Heart rate recovery (HRR) is a marker of vagal tone, which powerful predictor mortality in patients with cardiovascular disease. Sacubitril/valsartan (S/V) treatment for heart failure reduced ejection fraction (HFrEF), impressively impacts outcome. This study aims at evaluating the effects S/V on HRR and its correlation cardiopulmonary indexes HFrEF patients.Patients admitted to outpatients' services were screened out inclusion. was administered according guidelines. Up-titration performed...
atherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that particles (very (VLDL), intermediate-density (IDL)), could contribute to residual risk. The present study aims investigate the relationship between carotid intima-media thickness (IMT) and different subfractions a cohort of healthy postmenopausal women.75 women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical...
Abstract The high morbidity and poor survival rates associated with chronic heart failure still represent a big challenge, despite improvements in treatments the development of new therapeutic opportunities. prediction outcome is gradually moving towards multiparametric approach order to obtain more accurate models tailor prognostic evaluation individual characteristics single subject. Metabolic Exercise test data combined Cardiac Kidney Indexes (MECKI) score was developed 10 years ago from...
Chemotherapy cardiotoxicity is an emerging problem and it very important to prevent cardiac dysfunction caused by anticancer drugs. The aim of this study was assess the alterations function induced chemotherapy in a follow-up 2 years evaluate cardioprotective role angiotensin-converting enzyme inhibitors (ACEIs) prevention dysfunction.A prospective carried out using patients with breast cancer (85 women; median age 57 ± 12 years) other inclusion exclusion criteria. On basis treatment, were...
This single-center retrospective analysis aimed to evaluate the prognostic relevance of 6-min walk test (6MWT) in patients admitted an in-hospital cardiovascular rehabilitation program after open-heart valve surgery.One hundred one able perform a 6MWT within first week admission (time surgery: 16 ± 8 d) were included (age 68 11 y; 55% female; median left ventricular ejection fraction [interquartile range: 50-60]; 51% aortic surgery). Study endpoints death and combined outcome death/cardiac...
Nemaline myopathy (NM) is a rare congenital characterized by muscle weakness, hypotonia and the presence in fibers of inclusions known as nemaline bodies wide spectrum clinical phenotypes, ranging from severe forms with neonatal onset to asymptomatic forms. The adult-onset form heterogeneous terms presentation disease progression. Cardiac involvement occurs minority cases little about medical management this subgroup NM patients. We report case heart failure (HF) patient whom ivabradine...
An increasing number of studies with conflicting results regarding the association between angiotensin-converting enzyme (ACE) gene deletion polymorphism and cardiovascular disease has recently been published. The present prospective long-term study was conducted to evaluate whether DD genotype could also be associated a higher prevalence hypertension in healthy subjects over 6 years follow-up. We investigated effects ACE-I/D genotypes on diastolic function by echocardiography without any...
Previous studies showed that troponin blood levels may increase after exercise. In this study we assessed whether, among patients admitted with suspected unstable angina, the in high-sensitive T (hs-TnT) exercise stress test (EST) might help identify those obstructive coronary artery disease (CAD) and predict symptom recurrence during short term follow-up.Maximal treadmill EST was performed 69 consecutive to emergency room a suspicion of angina (acute chest pain but confirmed normal serum...