A5013182366- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Smoking Behavior and Cessation
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Influenza Virus Research Studies
- Obstructive Sleep Apnea Research
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Healthcare Technology and Patient Monitoring
- Immune cells in cancer
- Tracheal and airway disorders
- interferon and immune responses
- Kawasaki Disease and Coronary Complications
- Acute Kidney Injury Research
The Ohio State University
2018-2024
The Ohio State University Wexner Medical Center
2019-2022
Sutter Davis Hospital
2021
Lung Institute
2020
Ohio State University Hospital
2018
Abstract Mechanical ventilation generates injurious forces that exacerbate lung injury. These disrupt barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes non-coding oligonucleotides including microRNAs. In this study, we identify miR-146a as a mechanosensitive microRNA in alveolar macrophages has therapeutic potential to mitigate injury during mechanical ventilation. We use humanized in-vitro systems, mouse models, biospecimens from patients...
Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little known about its molecular regulation and cognate receptor, interferon receptor 1 (IFNLR1) human lung. We hypothesized that the IFNλ axis was active lung macrophages. In alveolar macrophages (HAMs), we observed increased IFNLR1 expression robust increase interferon-stimulated gene (ISG) response to ligand. While monocytes express minimal IFNLR1, differentiation of into...
Respiratory viruses, such as influenza, decrease airway cilia function and expression, which leads to reduced mucociliary clearance inhibited overall immune defense. Ubiquitination is a posttranslational modification using E3 ligases, plays role in the assembly disassembly of cilia. We examined membrane-associated RING-CH (MARCH) family ligases during influenza infection determined that MARCH10, specifically expressed ciliated epithelial cells, significantly decreased mice, human lung...
Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). support caspase-1 dimer formation inducing proximity mediated auto-activation caspase-1. Therefore, amount and nature in lung bronchoalveolar lavage fluid (BALF) might serve as marker inflammasome activity. Objectives: To determine whether concentrations or oligomerization status predicts function activity inflammation. Methods: BALF was...
Influenza remains a major public health challenge, as the viral infection activates multiple biological networks linked to altered host innate immunity. Following infection, IFN-λ, ligand crucial for resolution of infections, is known bind its cognate receptor, IFNLR1, in lung epithelia. However, little regarding molecular expression and regulation IFNLR1. Here, we show that IFNLR1 labile protein human airway epithelia rapidly degraded after influenza infection. Using an unbiased proximal...
Two challenges of trauma triage are to identify wounded who in danger imminent death and enable medics determine if resuscitation is possible when making ?dead or alive? decisions on the battlefield. Hemorrhagic shock leading cause combat injuries. The purpose this study was establish sequence vital sign cessation during lethal hemorrhage swine. Our hypothesis that brain electrical activity (electroencephalography [EEG]) respiration earlier indicators than traditional modalities measured...
1The Ohio State University Wexner Medical Center and Nationwide Children’s Hospital, Columbus, OH 2N/A, 3DO, 4Ohio
ABSTRACT During mechanical ventilation, injurious biophysical forces exacerbate lung injury. These disrupt alveolar capillary barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes non-coding oligonucleotides such as microRNAs. In this study, we identify miR-146a a mechanosensitive microRNA in macrophages that has therapeutic potential to mitigate injury during ventilation. We used humanized in-vitro systems, mouse models, biospecimens from...
Abstract Rationale Apoptosis-associated speck-like protein containing a CARD (ASC) serves as an adaptor to link NOD-like receptors caspase-1 during inflammasome activation. The oligomerization of ASC into large complex appears be crucial this process. Furthermore, extracellular specks may propagate inflammatory response. Although extremely high levels exist in BALF, little is known about whether BALF exists the soluble form or part speck complex. Methods Subjects (normal volunteers and...