A5102976318- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Pediatric health and respiratory diseases
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Allergic Rhinitis and Sensitization
- Pharmaceutical and Antibiotic Environmental Impacts
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- Receptor Mechanisms and Signaling
- Toxin Mechanisms and Immunotoxins
- Pesticide Residue Analysis and Safety
- Veterinary medicine and infectious diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pharmacological Effects and Assays
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
Huazhong Agricultural University
2017-2024
China Institute of Veterinary Drug Control
2021-2023
The First Hospital of Kunming
2019
Air Force General Hospital PLA
2018
Lishui Central Hospital
2013
Bacterial resistance is a growing problem worldwide, and the number of deaths due to drug increasing every year. We must pay great attention bacterial resistance. Otherwise, we may go back pre-antibiotic era have no drugs on which rely. result several causes, with efflux mechanisms widely recognised as significant factor in development variety chemotherapeutic antimicrobial medications. Efflux pump inhibitors, small molecules capable restoring effectiveness existing antibiotics, are...
Streptococcus suis (
Model informed drug development is a valuable tool for and clinical application due to its ability integrate variability uncertainty of data. This study aimed determine an optimal dosage ceftiofur against P. multocida by ex vivo pharmacokinetic/pharmacodynamic (PK/PD) model validate the regimens Physiological based Pharmacokinetic-Pharmacodynamic (PBPK/PD) model. The pharmacokinetic profiles both in plasma bronchoalveolar lavage fluid (BALF) are determined. PD performance was investigated....
Cefquinome is widely used to treat respiratory tract diseases of swine. While extra-label dosages cefquinome could improve clinical efficacy, they might lead excessively high residues in animal-derived food. In this study, a physiologically based pharmacokinetic (PBPK) model was calibrated on the published data and microdialysis experiment assess dosage efficiency food safety. For experiment, vitro/in vivo relative recovery concentration-time curves lung interstitium were investigated. This...
Abstract This study aimed to investigate the risk factors and whether acute hypercapnia contributes postoperative delirium (POD) during bronchoscopic intervention under general anesthesia or deep sedation. A prospective was conducted with 119 consecutive patients who had undergone between February 2016 December at Emergency General Hospital. Twenty-eight (23.8%) were diagnosed POD. The divided into 2 groups: POD (n = 28) control group 91). mean age of higher than that ( P < .01). All...
This prospective study compared pharmacokinetics (PK) and pharmacodynamics (PD) of linezolid in patients with sepsis receiving continuous venovenous hemofiltration (CVVH) extended daily (EDH).Patients treated CVVH or EDH were included. Serial blood samples collected concentrations measured. PKs analyzed using Pmetrics. Monte Carlo simulations used to evaluate PD target achievement.From 20 patients, 320 for PK analysis. profiles best described by a 2-compartment model. parameters not...
Enrofloxacin (ENR) granules were developed to prevent and control the infections caused by foodborne zoonotic intestinal pathogens in our previous studies. To promote further development of ENR standardize their usage pigs, a physiologically based pharmacokinetic (PBPK) model granule pigs was built determine withdrawal time (WT) evaluate toxicity pigs. Meanwhile, population WT determined Monte Carlo analysis guarantee pork safety. The fitting results showed that tissue residual...
The tissue kinetics of cyadox, an antibacterial agent used in food animals, and its major metabolites pigs, chickens, carp were investigated followed by a complete dietary exposure assessment to evaluate the safety cyadox. Cyadox metabolites, bisdeoxycyadox (Cy1), 4‐desoxycyadox (Cy2), N ‐(quinoxaline‐2‐methyl)‐cyanide acetyl hydrazine (Cy4), quinoxaline‐2‐carboxylic acid (Cy6), 2‐hydromethyl‐3‐hydroxy‐quinoxaline (Cy12), simultaneously quantitated with high‐performance liquid...
Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative gram-positive bacteria. The aim of this study was to derive an optimal dosage cefquinome S. with pharmacokinetic/pharmacodynamic (PK/PD) integration model the target infection site investigate cutoffs monitoring changes resistance. minimum inhibitory concentration (MIC) distribution 342 strains determined. MIC50...
<title>Abstract</title> <bold>Background</bold> Matrine (MT) exhibits antibiotic resistance reversal and antiviral activities <italic>in vitro</italic>. However, the vivo</italic> efficacies of MT amoxicillin (AMO)-MT combination cannot be accurately evaluated due to lack pharmacokinetics (PK) data. The aim this study was investigate PKs AMO in pigs after gavage administration each drug alone combination.<bold>Results</bold> Twenty-four were randomly distributed three treatments, namely...
Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion SAL pigs goats were investigated, the concentration correlations between edible tissues living samples analyzed find out suitable sample for pre-slaughter monitoring goats. After single oral dosage 1.2 mg/kg SAL, approximately 70% dose was excreted by from their excreta. When supplied feed containing (20 mg/kg) 14 consecutive days, high...
Introduction: Pneumonia is a common acute disease of the respiratory tract in childhood. In this paper, 700 cases pneumonia Changan Hospital Xi’an city [1-3] were summarized. All seasons are easy to occur, especially winter and spring. It recurrent attacks affect growth development children, if treatment not complete. The clinical data children reported as follows: Background: From January 2016 December 2016, hospital investigated 1 pairs [4]. Among 437 boys 263 women; 252 aged 2 occupied...
Objective To investigate effect of invasive-noninvasive sequential mechanical ventilation on treating patients with acute respiratory distress syndrome caused by severe pancreatitis.Methods 72 cases acture pancreatitis in our hospital from May 2009 to 2011 were randomly divided into two groups 36 each:treatment group (sequential group) and control (invasive group).PaO2,PaCO2,and pH measured before treatment 16 hours after both groups.The duration,case fatality,curative ratio,side incidence...
<b>Background:</b> Antibiotic combination and NIV have been widely applied in severe pneumonia patients, the advanced ventilation mode (e.g.average volume assured pressure support auto-titrating EPAP, AVAPS-AE) its impact rarely reported. <b>Objectives:</b> To evaluate effect of AVAPS-AE antibiotic for patients. <b>Methods:</b> A prospective, randomized controlled study,64 young(27.3±8.9 yrs)patients were included, who had a history chronic kidney disease (CKD)and immunosuppressant therapy....