A5062399279- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Pain Management and Placebo Effect
- Advanced Neuroimaging Techniques and Applications
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Neurological disorders and treatments
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Fluorescence Microscopy Techniques
- Vestibular and auditory disorders
- Heart Rate Variability and Autonomic Control
- Sirtuins and Resveratrol in Medicine
- Pain Mechanisms and Treatments
University of Science and Technology of China
2018-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2023
Center for Excellence in Brain Science and Intelligence Technology
2020
Chinese Academy of Sciences
2020
Hefei National Center for Physical Sciences at Nanoscale
2020
Glucagon-like peptide-1 (GLP-1) regulates energy homeostasis via activation of the GLP-1 receptors (GLP-1Rs) in central nervous system. However, mechanism by which signal controls blood glucose levels, especially different nutrient states, remains unclear. Here, we defined a population glucose-sensing GLP-1R neurons dorsomedial hypothalamic nucleus (DMH), endogenous decreases levels cross-talk between hypothalamus and pancreas. Specifically, illustrated sufficiency necessity DMH regulation....
Abstract Background Corticotropin-releasing hormone (CRH) is an important neuromodulator that widely distributed in the brain and plays a key role mediating stress responses autonomic functions. While distribution pattern of fluorescently labeled CRH-expressing neurons has been studied different transgenic mouse lines, full appreciation broad diversity this population local neural connectivity can only come from integration single-cell morphological information as defining feature. However,...
Abstract The cerebellum is involved in the control of movement, emotional responses, and reward processing. tree shrew closest living relative primates. However, little known not only about systematic nomenclature for but also detailed neurochemical characterization afferent projections. In this study, Nissl staining acetylcholinesterase histochemistry were used to reveal anatomical features shrews ( Tupaia belangeri chinensis ). cerebellar cortex presented a laminar structure. morphological...
Abstract The tree shrew ( Tupaia belangeri chinensis ) is the closest living relative of primates. Yet, little known about anatomical distribution tyrosine hydroxylase (TH)‐immunoreactive (ir) structures in hypothalamus shrew. Here, we provide first detailed description TH‐ir neurons shrews via immunohistochemical techniques. were widely distributed throughout majority hypothalamic found paraventricular nucleus (PVN) and supraoptic (SON), as was also observed human hypothalamus. In contrast,...
Hypothalamic corticotropin-releasing hormone (CRH) is a central driver of stress responses. How the CRH neurons regulate glucose release, especially during different time windows remains unknown. Here, we showed that adrenal activity required for release in delayed stage, but not early stage stress. Instead, initiated hypothalamus-sympathetic-liver (HSL) axis responds In HSL pathway, activates receptor subtype 2 (CRHR2) ventromedial hypothalamus (VMH) by inducing GABAA β3 subunit...
Abstract Corticotropin-releasing hormone (CRH) is an important neuromodulator with wide distribution in the brain. Here, we screened CRH-IRES-Cre;Ai32 mouse line to reveal morphologies of individual CRH neurons throughout brain by using fluorescence micro-optical sectioning tomography (fMOST) system. Diverse dendritic and projection fibers were found various regions. Reconstructions showed hypothalamic had smallest somatic volumes simplest branches, several regions shared a bipolar...