A5015055790- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Foreign Body Medical Cases
- Plant Pathogens and Resistance
- Nanoplatforms for cancer theranostics
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Plant Pathogens and Fungal Diseases
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverticular Disease and Complications
- Renal cell carcinoma treatment
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
Aichi Health Promotion Foundation
2023-2024
Kumamoto City Hospital
2021-2024
University of Miyazaki Hospital
2017-2021
University of Miyazaki
2016-2021
Kōchi University
2020
Hokkaido University
1999-2018
Hokkaido University Hospital
2014-2018
Obihiro Kosei General Hospital
2017
Kubota (Japan)
2015
Hirosaki National Hospital
2012
Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has gained popularity as an alternative to percutaneous biliary drainage for patients in whom endoscopic retrograde cholangiopancreatography failed. There are no previous studies comparing EUS-CDS with transpapillary stenting (ETS) first-line treatment distal malignant obstruction. The aim of this study was compare the clinical efficacy and safety ETS obstruction.A total 82 obstruction underwent initial using self-expandable metal...
Background: Irinotecan, oxaliplatin and leucovorin-modulated fluorouracil (FOLFIRINOX) the combination regimen of gemcitabine nanoparticle albumin-bound paclitaxel (GnP) (nab-PTX) improve prognosis patients with metastatic pancreatic cancer. However, no study has compared efficacy two regimens. We retrospectively safety regimens in unresectable Methods: Thirty-eight locally advanced or cancer received FOLFIRINOX GnP as first-line chemotherapy between December 2013 September 2015. In group,...
There exists a highly tumorigenic subset of esophageal squamous cell carcinoma (ESCC) cells defined by high expression CD44. A novel therapy targeting these cancer stem-like (CSCs) is needed to improve prognosis ESCC. CSCs ESCC have mesenchymal phenotype and epithelial-mesenchymal transition (EMT) critical enrich maintain CSCs. EGFR, frequently overexpressed in ESCC, has pivotal roles EMT induced TGF-β invasive fronts. Thus, fronts might be important for EGFR could target eliminating...
To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.In total, 118 cholangiocarcinoma underwent management [endoscopic nasobiliary (ENBD) or stenting] as a temporary in our institution between 2009 and 2014. We retrospectively evaluated all complications from initial to surgery palliative treatment. The risk factors reintervention, post-endoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis, percutaneous transhepatic...
Detecting superficial head and neck squamous cell carcinoma (HNSCC) by endoscopy is challenging because of limited morphological hallmarks, iodine cannot be applied to lesions due severe mucosal irritation. γ-glutamyltranspeptidase (GGT), a surface enzyme, overexpressed in several cancers, it has been reported that γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), fluorescent targeting agent which can enzymatically activated becomes after cleavage GGT-specific sequence, within few...
Abstract Background Bilateral self‐expandable metallic stent ( SEMS ) placement for the management of unresectable malignant hilar biliary obstruction UMHBO is technically challenging to perform using existing stents with thick delivery systems. The recently developed 6‐ F r systems could facilitate a single‐step simultaneous side‐by‐side through accessory channel duodenoscope. aim this study was evaluate feasibility procedure. Methods Between M ay and S eptember 2013, 13 consecutive...
Kazumichi Kawakubo, Kei Yane, Kazunori Eto, Hirotoshi Ishiwatari, Nobuyuki Ehira, Shin Haba, Ryusuke Matsumoto, Keisuke Shinada, Hiroaki Yamato, Taiki Kudo, Manabu Onodera, Toshinori Okuda, Yoko Taya-Abe, Shuhei Kawahata, Kimitoshi Kubo, Yoshimasa Kubota, Masaki Kuwatani, Hiroshi Kawakami, Akio Katanuma, Michihiro Ono, Tsuyoshi Hayashi, Minoru Uebayashi, and Naoya Sakamoto. Gut Liver 2018;12:353-9. https://doi.org/10.5009/gnl17293
In hepatocellular carcinoma (HCC), there exists a highly tumorigenic subset of cells defined by high expression CD44 and CD133 that has been reported to contain cancer stem-like (CSCs). Krüppel-like factor 5 (KLF5) regulates many factors involved in cell cycle, migration, inflammation, angiogenesis stemness cancer-promoting effects some cancers. While reports have indicated KLF5 may important roles regulation CSCs, what role, if any, plays CSCs HCC remains be elucidated. Flow cytometric...
Every-week (ew) adalimumab (ADA) maintenance following induction therapy with a standard regimen has recently been approved for use in Japan. The efficacy and safety of combination ew-ADA plus intensive granulocyte monocyte adsorptive apheresis (GMA) (two sessions/week) the treatment refractory ulcerative colitis (UC) displaying failure conventional, biologics Janus kinase inhibitor have not evaluated previously. present retrospective study 10-week this among UC patients. Six patients were...
Endoscopic ultrasonography (EUS)-guided drainage of liver abscesses has recently become available. We present here a case successful abscess using dedicated wide fully covered self-expandable metallic stent (FCSEMS) with flared ends.
Endoscopic double self-expandable metallic stent (SEMS) placement by the partial stent-in-stent (PSIS) method has been reported to be useful for management of unresectable hilar malignant biliary obstruction. However, it is technically challenging, and optimal SEMS procedure remains unknown. The aim this study was identify risk factors technical failure endoscopic obstruction (MHBO).Between December 2009 May 2013, 50 consecutive patients with MHBO underwent PSIS method. We retrospectively...
Obstructive jaundice has been reported to influence liver elasticity, independent of fibrosis. The aim our prospective study was evaluate the changes in before and after biliary drainage, patients with obstructive jaundice, correlation between elasticity measures serum markers fibrosis.This is a cohort 20 jaundice. Liver assessed by Transient Elastography (TE) Virtual Touch™ Quantification (VTQ). Serum total bilirubin (T-Bil) level measured drainage (Day 0), repeated at 2 days 2) 7 7)...
In 1970, a Japanese group reported the first use of endoscopic retrograde cholangiopancreatography (ERCP), which is now carried out worldwide. Selective bile duct cannulation mandatory technique for diagnostic and therapeutic ERCP. Development endoscope other devices has contributed to extended ERCP, become basic procedure diagnose treat pancreaticobiliary diseases. Various techniques related selective have been widely applied. Although classical contrast medium injection remains valuable,...
Endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS) is used after failed endoscopic retrograde cholangiopancreatography (ERCP) [1]. Manipulation of the guidewire one most challenging techniques in EUS-HGS. We present a successful case rescue technique using multilumen catheter [2], namely an uneven double-lumen cannula (Piolax Medical Devices, Yokohama, Kanagawa, Japan) ([Fig. 1]), for
A 44-year-old woman who had been diagnosed with ulcerative colitis (UC) at 22 years old was severe flare-up of UC based on endoscopic findings associated new-onset active pyoderma gangrenosum (PG) both lower legs after she decided to discontinue treatment. Systemic treatment intravenous prednisolone 30 mg/day achieved insufficient response and PG, resulting in a diagnosis corticosteroid-refractory PG. Combination therapy upadacitinib 45 plus intensive granulocyte monocyte adsorptive...
We describe the case a 92-year-old woman who was admitted to our hospital with choledocholithiasis and periampullary diverticulum (PAD). Due PAD, clear visualization of ampulla Vater could not be obtained. Although selective bile duct cannulation difficult, 7-Fr plastic stent placed during first session. Fifteen days later, endoscopic retrograde cholangiopancreatography retried using traction devices, papilla became visible. Endoscopic sphincterotomy stone extraction were performed without...
Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) is an established technique for various pancreatic lesions. However, Roux-en-Y reconstruction (RY) sometimes considered a relative contraindication of EUS-FNA.[1] Here, we present two successful cases EUS-FNA using new curved linear echoendoscope (CLE) in patients with RY. Case 1: A 72-year-old man was admitted after total gastrectomy RY gastric cancer 10 years prior. Computed tomography (CT) revealed low-density mass the...