A5012228351- Cancer-related molecular mechanisms research
- RNA regulation and disease
- RNA Research and Splicing
- Obstructive Sleep Apnea Research
- Cardiovascular Syncope and Autonomic Disorders
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Vagus Nerve Stimulation Research
- Cellular transport and secretion
- Fish biology, ecology, and behavior
- Plant and Fungal Interactions Research
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Sleep and related disorders
- Sleep and Wakefulness Research
- Circular RNAs in diseases
- Scientific Computing and Data Management
- Nasal Surgery and Airway Studies
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Hedgehog Signaling Pathway Studies
- Heart Rate Variability and Autonomic Control
- melanin and skin pigmentation
University of California, San Francisco
2018-2024
Cancer Research Center
2018-2024
Cancer Research Institute
2023
Broad Center
2023
University of California, Berkeley
2018-2020
University of California San Francisco Medical Center
2018
Abstract Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified nuclear-enriched lncRNA ( AC004540.4 ) that is upregulated NRAS/MAPK-dependent melanoma, named T-RECS . Considering potential innovative treatment...
During the novel coronavirus disease 2019 pandemic, telehealth has become a vital component of health care delivery. For otolaryngology evaluations, examination ear and oropharynx is important but difficult to achieve remotely.To assess feasibility patient use low-cost digital videoscopes smartphones for oropharynx.A prospective quality improvement study was conducted in an academic adult clinic including 23 patients who presented in-person appointment owned smartphone device. The from July...
The long non-coding RNA (lncRNA) MALAT1 is a regulator of oncogenesis and cancer progression. MAPK-pathway upregulation the main event in development progression human cancer, including melanoma recent studies have shown that has significant impact on regulation gene protein expression MAPK pathway. However, role kinases RAS, RAF, MEK ERK largely unknown. We demonstrate impacts antisense oligonucleotide (ASO)-based MALAT1-inhibition melanoma. Our results showed MALAT1-ASO treatment decreased...
Objectives Obstructive sleep apnea (OSA) is usually assessed at discrete and infrequent timepoints. Wearable consumer technologies (CST) may allow for more granular longitudinal assessments of OSA therapy responses OSA‐related symptoms. Methods In this case series, we enrolled hypoglossal nerve stimulator (HGNS) patients who had an effective treatment response 8‐week study using a wearable CST. Participants started with “HGNS‐on,” were randomized to turn off HGNS during either week 4 or 5...
To assess SARS-CoV-2 outcomes, we matched a municipal COVID-19 registry and clinic rosters from primary care network containing large HIV assessed clinical outcomes by status. The risk of severe was higher among people with (PWH, adjusted relative = 1.84, 95% confidence interval 1.05-3.25), while incidence lower despite testing rates. vaccination campaigns should prioritize PWH to prevent disease given potentially risk.
Pembrolizumab is an anti–programmed cell death receptor protein-1 (PD-1) monoclonal antibody first approved in 2014 by the US Food and Drug Administration for treatment of metastatic melanoma. targets PD-1, blocking immune checkpoint subsequently boosting response against cancerous cells. Although effective systemic disease, anti–PD-1 therapy also associated with adverse effects such as vitiligo pruritus caused overstimulation hyperproliferation system.
This preliminary study investigates hypoglossal nerve stimulator (HNS) amplitude changes and usage patterns during the initial HNS uptitration period to characterize when patients achieve their therapeutic amplitude. therapy amplitudes, duration, pause times were examined across first 4 months of implant use. Average increased monthly from baseline (0.7 ± 0.3 V) (1.1 V), second (1.4 0.4 third (1.7 0.5 fourth (1.8 (P < .001). After months, 60% had reached a was greater for who did not by...
Longitudinal snoring changes can be captured using a mobile phone application. During hypoglossal nerve stimulator (HNS) therapy up-titration, increasing stimulation voltage was associated with reduced frequency and intensity in this case series of six patients. Laryngoscope, 2023 Jolie L. Chang is supported by the San Francisco Veterans Affairs Health Care System. The contents do not represent views US Department or those government. authors have no other financial relationships conflicts...
Abstract MAPK-pathway up-regulation is responsible for over 40% of human cancer cases. Finding effective therapeutic targets melanoma therapy continues to be a challenge due drug resistance. Using computational and experimental pipeline, we discovered the nuclear enriched long non-coding RNA (lncRNA) TRASH, which induced upon MAPK-pathway-activation in melanoma. LncRNA hold essential regulatory functions many types. TRASH-targeting Antisense Oligonucleotides (TRASH-ASOs) greatly reduced...
Abstract Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified nuclear-enriched lncRNA ( AC004540.4 ) that is upregulated NRAS/MAPK-dependent melanoma, named T-RECS . Considering potential innovative treatment...
Abstract Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified nuclear-enriched lncRNA ( AC004540.4 ) that is upregulated NRAS/MAPK-dependent melanoma, named T-RECS . Considering potential innovative treatment...
It is our great honor and pleasure to welcome you the 2021 IEEE International Conference on Cyber,Physical Social Computing (CPSCom 2021) hosted virtually due COVID-19 pandemic Dec. 06-08, 2021.