A5068682281- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Tuberculosis Research and Epidemiology
- Bone and Dental Protein Studies
- Viral gastroenteritis research and epidemiology
- Digestive system and related health
- Genomics and Phylogenetic Studies
- Trace Elements in Health
- Calcium signaling and nucleotide metabolism
- Mesenchymal stem cell research
- Cancer therapeutics and mechanisms
- CRISPR and Genetic Engineering
- interferon and immune responses
- Microbial Community Ecology and Physiology
- Salmonella and Campylobacter epidemiology
- Aquaculture disease management and microbiota
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
Duke University
2021-2024
Washington University in St. Louis
2019-2023
Durham Technical Community College
2022
The immune response to Mycobacterium tuberculosis infection determines disease outcomes, yet we have an incomplete understanding of what factors contribute a protective response. Neutrophilic inflammation has been associated with poor prognosis in humans and animal models during M. and, therefore, must be tightly regulated. ATG5 is essential autophagy protein that required innate cells control neutrophil-dominated promote survival infection; however, the mechanistic basis for how regulates...
Salmonella causes ∼1 million cases of gastroenteritis annually in the United States. Critical to virulence are secreted effectors that reprogram host functions. We previously discovered effector SarA facilitates phosphorylation STAT3, inducing expression anti-inflammatory cytokine interleukin-10 (IL-10). This STAT3 activation requires a region homology with receptor gp130. Here, we demonstrate single amino acid difference is critical for bias SarA-STAT3 signaling. An isoleucine at pY+1 YxxQ...
serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal fever
Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis Of the 10 million cases of in 2017, approximately 19% new and 43% previously treated were strains M. resistant at least one frontline antibiotic. There clear need for therapies target these genetically strains. Here, we report discovery series antimycobacterial compounds, 4-amino-thieno[2,3-d]pyrimidines, potently inhibit growth To...
Highlights•Cellular GWAS revealed MCOLN2 as an inhibitor of S. Typhi intracellular replication•MCOLN2 acts inward rectifying Mg2+ channel on endolysosomes•MCOLN2 deprives to restrict growth•S. replication in knockout cells depends bacterial PhoPQ signalingSummaryHuman genetic diversity can reveal critical factors host-pathogen interactions. This is especially useful for human-restricted pathogens like Salmonella enterica serovar (S. Typhi), the cause typhoid fever. One key defense during...
Osteopontin (OPN) has been considered a potential biomarker of graft-versus-host disease (GVHD). However, the function OPN in GVHD is still elusive. Using mouse model acute (aGVHD), we report that generated by CD4+ T cells sufficient to exert beneficial effect controlling aGVHD through limiting gastrointestinal pathology, major target organ aGVHD. cell-derived works on CD44 expressed intestinal epithelial (IECs) and abates cell death IECs. also modulates gut microbiota with enhanced...
Non-typhoidal
Abstract Human genetic diversity can reveal critical factors in host-pathogen interactions. This is especially useful for human-restricted pathogens like Salmonella enterica serovar Typhi ( S . Typhi), the cause of Typhoid fever. One key dynamic during infection competition nutrients: host cells attempt to restrict intracellular replication by depriving bacteria nutrients or delivering toxic metabolites a process called nutritional immunity. Here, cellular genome-wide association study...
ABSTRACT The immune response to Mycobacterium tuberculosis infection determines disease outcomes, yet we have an incomplete understanding of what factors contribute a protective response. Neutrophilic inflammation has been associated with poor prognosis in humans and animal models during M. and, therefore, must be tightly regulated. ATG5 is essential autophagy protein that required innate cells control neutrophil-dominated promote survival infection, however, the mechanistic basis for how...