A5084307248- Gut microbiota and health
- Pregnancy and Medication Impact
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Pharmacogenetics and Drug Metabolism
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Reproductive Health and Contraception
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Viral gastroenteritis research and epidemiology
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Light effects on plants
- Tryptophan and brain disorders
Université de Toulouse
2021-2024
Université Toulouse III - Paul Sabatier
2021-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Toxalim Research Centre in Food Toxicology
2021-2024
École Nationale Vétérinaire de Toulouse
2021-2024
Objective We evaluated the influence of sex on pathophysiology non-alcoholic fatty liver disease (NAFLD). investigated diet-induced phenotypic responses to define sex-specific regulation between healthy and NAFLD identify influential pathways in different preclinical murine models their relevance humans. Design Different (high-fat diet, choline-deficient high-fat Western diet or supplemented with fructose glucose drinking water) were compared a control male female mice. performed metabolic...
Liver physiology is circadian and sensitive to feeding insulin. Food intake regulates insulin secretion a dominant signal for the liver clock. However, how much contributes effect of on clock rhythmic gene expression remains be investigated. Insulin action partly depends changes in receptor (IR)-dependent expression. Here, we use hepatocyte-restricted deletion IR evaluate its role regulation oscillation as well programming adult mouse liver. We find that, absence IR, rhythmicity core-clock...
Insulin and other growth factors are key regulators of liver gene expression, including in metabolic diseases. Most the phosphoinositide 3-kinase (PI3K) activity induced by insulin is considered to be dependent on PI3Kα. We used mice lacking p110α, catalytic subunit PI3Kα, investigate its role regulation expression health dysfunction-associated steatotic disease (MASLD). The absence hepatocyte PI3Kα reduced maximal insulin-induced PI3K signaling, promoted glucose intolerance lean...
Abstract Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the sensors and effectors of microbial signals are not well defined. Results By comparing publicly available liver transcriptomics data from conventional vs. germ-free mice, we identified pregnane X receptor (PXR, NR1I2) transcriptional activity strongly affected by absence microbes. Microbiota depletion using antibiotics Pxr +/+ vs -/- C57BL/6J...
The constitutive androstane receptor (CAR) is a nuclear that binds diverse xenobiotics and whose activation leads to the modulation of expression target genes involved in xenobiotic detoxification energy metabolism. Although CAR hepatic activity considered be higher women than men, its sex-dependent response an acute pharmacological has seldom been investigated.The transcriptome, plasma markers, metabolome, were analysed Car+/+ Car-/- male female mice treated either with CAR-specific agonist...
Aims: Although prebiotics, probiotics, and fecal transplantation can alter the sensation of hunger and/or feeding behavior, role constitutive gut microbiota in short-term regulation food intake during normal physiology is still unclear. Results: An antibiotic-induced depletion study was designed to compare behavior conventional microbiota-depleted mice. Tissues were sampled characterize time profile microbiota-derived signals mice consumption either standard or high-fat for 1 h....
Scope Non‐alcoholic fatty liver disease (NAFLD) is a sexually dimorphic influenced by dietary factors. Here, the metabolic and hepatic effects of amino acid (AA) source assessed in Western diet (WD)‐induced NAFLD male female mice. Methods results The AA either casein or free mixture mimicking composition casein. As expected, males fed casein‐based WD display glucose intolerance, fasting hyperglycemia, insulin‐resistance develop associated with changes gene expression microbiota dysbiosis. In...
Abstract Insulin and other growth factors are key regulators of liver gene expression, including in metabolic diseases. Most the phosphoinositide 3-kinase (PI3K) activity induced by insulin is dependent on PI3Kα. We used mice lacking p110α, catalytic subunit PI3Kα, to investigate its role regulation expression health Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). The absence hepatocyte PI3Kα signaling promoted glucose intolerance lean significantly regulated...
Metabolic dysfunction-associated steatotic liver disease (MASLD), and its more advanced stage metabolic steatohepatitis, is the most common chronic disease, constituting a major public health issue. No medication approved for MASLD treatment, relevant preclinical models are needed to define molecular mechanisms underlying pathogenesis, evaluate therapeutic approaches. Here we demonstrated that compared standard temperature housing, thermoneutral housing aggravated western diet (WD)-induced...
Abstract A crucial early-life developmental phase regulates microbiome settling while establishing critical and long-lasting immune metabolic processes. During this period, the influence of select components maternal diet on offspring microbiota health remains largely unknown. To investigate potential transgenerational impact exposure to microbiota-disrupting factors, dams were subjected prior breeding dietary emulsifiers, known directly perturb microbiota. Such induced alterations in which...
ABSTRACT Background and Aims The constitutive androstane receptor (CAR) is a nuclear able to recognize large panel of xenobiotics leading the modulation expression its target genes involved in xenobiotic detoxication energy metabolism. While CAR hepatic activity thought be higher women than men, response an acute pharmacological activation has never been investigated both sexes. Methods Hepatic transcriptome, plasma metabolome, have analyzed Car +/+ -/- male female mice treated either with...
SUMMARY In mammalian cells, gene expression is rhythmic and sensitive to various environmental physiological stimuli. A circadian clock system helps anticipate synchronize with daily stimuli including cyclic light food intake, which control the central peripheral programs, respectively. Food intake also regulates insulin secretion. How much contributes effect of feeding on entrainment remains be investigated. An important component action mediated by changes in receptor (IR)-dependent...