A5086780389- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- Skin Protection and Aging
- Myasthenia Gravis and Thymoma
- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Consumer Attitudes and Food Labeling
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Wound Healing and Treatments
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Child Nutrition and Feeding Issues
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Eating Disorders and Behaviors
- Gut microbiota and health
University of Milan
2014-2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2010-2013
IRCCS Istituto Auxologico Italiano
2013
Endurance exercise training increases cardiac energy metabolism through poorly understood mechanisms. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) in cardiomyocytes contributes to adaptation. Here we demonstrate that the donor diethylenetriamine-NO (DETA-NO) activated mitochondrial biogenesis and function, as assessed upregulated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), nuclear respiratory factor 1, transcription A (Tfam) expression, increased DNA...
Abstract Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation, heart failure. Microscopically, EAT is composed adipocytes, nerve tissues, inflammatory, stromovascular, immune cells. Epicardial white tissue, albeit it also has brown fat-like or beige features. No muscle fascia divides myocardium; this allows direct interaction crosstalk between fat myocardium. Thus, might be therapeutic target for...
Crohn's disease (CD) is notably characterized by the expansion of visceral fat with small adipocytes expressing a high proportion anti-inflammatory genes. Conversely, depots in ulcerative colitis (UC) patients have never been characterized. Our study aims were a) to compare adipocyte morphology and gene expression profile bacterial translocation omental (OM) mesenteric (MES) adipose tissue UC CD, b) investigate effect infection on proliferation vitro. Specimens OM MES collected from 11 CD...
Abstract Aims Heart failure with reduced ejection fraction (HFrEF) is a leading cause of mortality worldwide, requiring novel therapeutic and lifestyle interventions. Metabolic alterations energy production deficit are hallmarks thereby promising targets for this complex clinical syndrome. We aim to study the molecular mechanisms effects on cardiac function in rodents HFrEF designer diet which free essential amino acids—in specifically designed percentages—substituted protein. Methods...
Chronic alcohol consumption promotes mitochondrial dysfunction, oxidative stress, defective protein metabolism, and fat accumulation in hepatocytes (liver steatosis). Inadequate amino acid metabolism is worsened by malnutrition, frequently present alcohol-consuming patients, with reduced circulating branched-chain acids (BCAAs). Here we asked whether dietary supplementation a specific mixture, enriched BCAAs (BCAAem) able to promote function muscle of middle-aged rodents, would prevent...
Anthracycline anticancer drugs, such as doxorubicin (DOX), can induce cardiotoxicity supposed to be related mitochondrial damage. We have recently demonstrated that a branched-chain amino acid (BCAA)-enriched mixture (BCAAem), supplemented with drinking water middle-aged mice, was able promote biogenesis in cardiac and skeletal muscle. To maximally favor increase oxidative metabolism function, here we tested new original formula, composed of essential acids, tricarboxylic cycle precursors...
Over the past decades, a generalised increase in food portion sizes has probably contributed to growing global obesity epidemic. Increasing awareness of appropriate could contribute reversing this trend through better control calorie intake. In study, comparison standard European countries for various categories shows wide variability their importance food, nutrient, and energy consumption according government institutional websites. On other hand, overall averages appear be largely line...
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary molecular mechanisms able to improve is paramount medical importance because such can be leveraged as a therapy for obesity related disorders. Here, we show that designer protein-deprived diet enriched free essential amino acids 1) promote the brown fat thermogenic program fatty acid oxidation, 2) stimulate uncoupling protein 1 (UCP1)-independent respiration subcutaneous white...
Article2 December 2019Open Access Source DataTransparent process Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy Pamela Bella Stem Cell Laboratory, Department Pathophysiology Transplantation, Unit Neurology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universitá degli Studi di Milano, Milan, Italy Search for more papers by this author Andrea Farini Stefania Banfi Hematology IRCCS, Oncology Hemato-oncology,...
Aims: Myopathy, characterized by mitochondrial oxidative stress, occurs in ∼10% of statin-treated patients, and a major risk exists with potent statins such as rosuvastatin (Rvs). We sought to determine whether peculiar branched-chain amino acid-enriched mixture (BCAAem), found improve function reduce stress muscle middle-aged mice, was able prevent Rvs myopathy. Results: Dietary supplementation BCAAem the structural functional alterations induced young mice. Rvs-increased plasma...
Profound metabolic alterations characterize cancer development and, beyond glucose addiction, amino acid (AA) dependency is now recognized as a hallmark of tumour growth. Therefore, targeting the addiction tumours by reprogramming their substrate utilization an attractive therapeutic strategy. We hypothesized that dietary approach targeted to stimulate oxidative metabolism could reverse inflexibility and represent proper adjuvant therapy.We measured in xenografted mice fed with designer,...
Duchenne muscular dystrophy (DMD) is one of the most common and severe forms dystrophy. Oxidative myofibre content, muscle vasculature architecture exercise tolerance are impaired in DMD. Several studies have demonstrated that nutrient supplements ameliorate dystrophic features, thereby enhancing performance. Here, we report dietary supplementation with a specific branched-chain amino acid-enriched mixture (BCAAem) increased abundance oxidative fibres associated endurance mdx mice....
In the current study, we investigated whether naturally occurring CD4(+)CD25(+) T cells, separated by immunomagnetic anti-CD4 and anti-CD25 Abs from naive animals, are able to protect experimental autoimmune myasthenia gravis (EAMG) modify progression of ongoing disease when administered Torpedo californica acetylcholine receptor (AChR)-immunized Lewis rats. Even though CD4(+)CD25(high) cell frequencies were similar in spleens lymph nodes EAMG healthy rats, observed that cells isolated...
The effects of high-potency statins on renal function are controversial. To address the impact morpho-functional aspects, normotensive young mice were treated with rosuvastatin (Rvs). Moreover, because may impair mitochondrial function, received either dietary supplementation an amino acid mixture enriched in essential acids (EAAm), which we previously demonstrated to increase biogenesis muscle or unsupplemented control diet for 1 month. Mitochondrial and apoptosis, insulin signaling pathway...
Mitochondrial dysfunction plays a key role in the aging process, and is strong risk factor for neurodegenerative diseases or brain injury characterized by impairment of mitochondrial function. Among these, ischemic stroke one leading causes death permanent disability worldwide. Pharmacological approaches its prevention therapy are limited. Although non-pharmacological interventions such as physical exercise, which promotes biogenesis, have been shown to exert preventive effects against...
Proper maintenance of mitochondrial homeostasis is essential for cell health, and dysfunction underlies several metabolic heart diseases. Stimulation biogenesis represents a valuable therapeutic tool the prevention treatment disorders characterized by deficit in energy metabolism. The present study aimed to potentiate biogenetic efficacy an amino acid (AA) mixture, enriched branched-chain acids (BCAAs), which we previously showed boost biogenesis, leading life span extension reducing muscle...
Corneal disorders are frequent, involving most diabetic patients; among its manifestations, they include delayed wound healing. Since maintenance of mitochondrial homeostasis is fundamental for the cell, stimulation biogenesis represents a unique therapeutic tool preventing and treating with deficit in energy metabolism. We have recently demonstrated that branched-chain amino acid (BCAA)-enriched mixture (BCAAem) supported cardiac skeletal muscle, reduced liver damage caused by alcohol,...