A5053696763- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- RNA Research and Splicing
- Polymer Nanocomposites and Properties
- Liver physiology and pathology
- Polymer composites and self-healing
- Plant responses to water stress
- Flame retardant materials and properties
- Mesenchymal stem cell research
- PARP inhibition in cancer therapy
- Phagocytosis and Immune Regulation
- Endometriosis Research and Treatment
- Conducting polymers and applications
- Reproductive Biology and Fertility
- Glycosylation and Glycoproteins Research
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- DNA Repair Mechanisms
- Pigment Synthesis and Properties
- Catalytic Processes in Materials Science
- Sperm and Testicular Function
Fuzhou University
2025
Tehran University of Medical Sciences
2023
UPMC Hillman Cancer Center
2017
University of Pittsburgh
2013-2016
Lysosomes are acidic organelles that have a crucial role in degrading intracellular macromolecules and during the final stage of autophagy. Tetrandrine (Tet), bisbenzylisoquinoline alkaloid, was reported as an autophagy activator. Here, contrast with previous studies, we show Tet is potent lysosomal deacidification agent able to block autophagic flux degradation stage. Single-agent induces significant apoptosis both vitro xenograft models. In presence Tet, preceded by robust accumulation...
The poor resistance of high-density polyethylene (HDPE) to thermal-oxidative aging and ultraviolet (UV) degradation significantly limits its service life. In this study, the nanocomposite ZnO-AO was synthesized using γ-glycidoxypropyltrimethoxysilane (GPTMS) as a bridging agent, which facilitated loading significant quantity hindered phenolic antioxidant (AO) onto surface ZnO nanoparticles, HDPE/ZnO-AO composites were subsequently prepared by melt blending. results indicated that combination...
Androgens are known to protect prostate cancer cells from DNA damage. Recent studies showed regulation of repair genes by androgen receptor signaling in cancers. ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor and its intracellular localization can be modulated ultraviolet light, suggesting a potential role for EAF2 cells. Here we show that knockdown or homolog EAF1 sensitized damage the sensitization did not require p53. knockout mouse was also γ-irradiation....