A5006756475- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Research in Cotton Cultivation
- Pancreatic and Hepatic Oncology Research
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Liver Disease and Transplantation
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Polyamine Metabolism and Applications
- Neuroblastoma Research and Treatments
- Dietary Effects on Health
- Plant Virus Research Studies
- Acupuncture Treatment Research Studies
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Digestive system and related health
- Pelvic and Acetabular Injuries
- Colorectal and Anal Carcinomas
The Royal Melbourne Hospital
2023-2024
The University of Melbourne
2018-2024
University of Bonn
2023-2024
Harbin Medical University
2023-2024
First Affiliated Hospital of Harbin Medical University
2023
The First Affiliated Hospital, Sun Yat-sen University
2014-2020
Sun Yat-sen University
2014-2020
Peter MacCallum Cancer Centre
2015-2020
The Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) was established by the International Society for Gastrointestinal Tumours and Clinical Genome Resource, who set out to develop recommendations interpretation of germline APC variants underlying Familial Adenomatous Polyposis, most frequent hereditary polyposis syndrome.
Abstract Background It is known that gene- and disease-specific evidence domains can potentially improve the capability of ACMG/AMP classification criteria to categorize pathogenicity for variants. We aimed include gene–disease-specific clinical, predictive, functional domain specifications with respect MMR genes. Methods Starting original (InSiGHT criteria) developed by InSiGHT Variant Interpretation Committee, we systematically addressed enable more comprehensive assessment within ClinGen...
Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare subtype of primary liver cancers. Its prognostic factors remain unclear. The study aimed to evaluate its long-term outcome by retrospectively reviewing the series cHCC-CC after curative resection from our institute.A total 55 pathologically confirmed patients undergoing resections between January 2003 2018 at First Affiliated Hospital Sun Yat-sen University (Guangzhou, China) were included. clinicopathological...
Thoracic radiotherapy (RT) is required for the curative management of inoperable lung cancer, however, treatment delivery limited by normal tissue toxicity. Prior studies suggest that using radiation-induced DNA damage response (DDR) in peripheral blood mononuclear cells (PBMC) has potential to predict RT-associated toxicities. We collected PBMC from 38 patients enrolled on a prospective clinical trial who received definitive fractionated RT non-small cell cancer. DDR was measured automated...
Background: With the feature of destructive and biliary malignancy, intrahepatic cholangiocarcinoma (ICC), presents unclear molecular mechanisms which contributes to typically poor prognosis for patients. Seizure-related 6 homolog-like 2 (SEZ6L2) is a gene that encodes seizure-associated protein localized on cell surface. Thus far, function SEZ6L2 in ICC has not been reported. Methods: We used data from The Cancer Genome Atlas Gene Expression Omnibus analyze dynamics behind levels expression...
BACKGROUND: Percutaneous kyphoplasty (PKP) or percutaneous short-segment fixation (PSSF) is often used to treat Kummell’s disease. However, it not clear which treatment better for patients. OBJECTIVE: To retrospectively compare the clinical efficacy of PVP and PSSF METHOD: 60 patients were involved in this research period follow-up was at least 2 years. 27 them treated with (Group I) rest who received II). The visual analog scale (VAS) radiographic indexes each participant had been measured...
Abstract Background Pathogenic constitutional APC variants underlie familial adenomatous polyposis, the most common hereditary gastrointestinal polyposis syndrome. To improve variant classification and resolve interpretative challenges of uncertain significance (VUS), APC-specific ACMG/AMP criteria were developed by ClinGen-InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP). Methods A streamlined algorithm using -specific was applied to assess all in ClinVar...
Objective To investigate the proliferation,apoptosis and migration of boron neutron capture therapy(BNCT) for C6 rat glioma cell-line.Methods The cells,cultured by 10 B-DMEM with irradiation in-hospital irradiator (IHNI),were divided into three groups:BNCT 3 Gy (Group Ⅰ),BNCT 6 Ⅱ),untreated control lⅢ).The MTT assay was used to indentified cell proliferation draw growth curve at 1-7 days post-irradiation.The apoptosis rate detected flow cytometer (FCM) after 72 h irradiation.Cell scratch...