Atli S. Valgardsson
A5047380861- RNA and protein synthesis mechanisms
- Cardiovascular Effects of Exercise
- Hearing, Cochlea, Tinnitus, Genetics
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Genetic Associations and Epidemiology
National University Hospital of Iceland
2017-2021
Abstract Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding associated with risk through unknown mechanisms. We performed a meta-analysis GWAS among 29,502 cases and 767,760 controls from Iceland the UK Biobank follow-up samples Norway US, focusing on low-frequency coding splice aiming to identify causal genes. observe associations one missense (OR = 1.20) splice-donor variant 1.50) RPL3L , first ribosomal gene...
Abstract Aims The aim of this study was to use human genetics investigate the pathogenesis sick sinus syndrome (SSS) and role risk factors in its development. Methods results We performed a genome-wide association 6469 SSS cases 1 000 187 controls from deCODE genetics, Copenhagen Hospital Biobank, UK HUNT study. Variants at six loci associated with SSS, reported missense variant MYH6, known atrial fibrillation (AF)/electrocardiogram variants PITX2, ZFHX3, TTN/CCDC141, SCN10A low-frequency...
Abstract We performed a meta-analysis of genome-wide association studies on atrial fibrillation (AF) among 14,710 cases and 373,897 controls from Iceland 14,792 393,863 the UK Biobank, focusing low frequency coding splice mutations, with follow-up in samples Norway US. observed associations two missense (OR=1.19 for both) one splice-donor mutation (OR=1.52) RPL3L , encoding ribosomal protein primarily expressed skeletal muscle heart. Analysis 167 RNA right atrium revealed that donor results...