A5103275605- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Cryospheric studies and observations
- Remote Sensing and Land Use
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Climate change and permafrost
- Virus-based gene therapy research
- Veterinary medicine and infectious diseases
- Toxin Mechanisms and Immunotoxins
- Landslides and related hazards
- Humic Substances and Bio-Organic Studies
- Animal Virus Infections Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- SARS-CoV-2 and COVID-19 Research
- Automated Road and Building Extraction
- Reproductive tract infections research
- Remote Sensing in Agriculture
- Signaling Pathways in Disease
- Smart Materials for Construction
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Tree-ring climate responses
- SARS-CoV-2 detection and testing
- Advanced Image Fusion Techniques
Chinese Academy of Sciences
2020-2022
Institute of Microbiology
2020-2022
University of Chinese Academy of Sciences
2021
Northwest Institute of Eco-Environment and Resources
2021
China Agricultural University
2013-2014
Ebola virus (EBOV) is one of the most virulent pathogens that causes hemorrhagic fever and displays high mortality rates low prognosis in both humans nonhuman primates. The post-exposure antibody therapies to prevent EBOV infection are considered effective as yet. However, owing poor thermal stability mammalian antibodies, their application tropics has remained limited. Therefore, a thermostable therapeutic against was developed modelled on poultry(chicken) immunoglobulin Y (IgY). IgY...
During influenza A epidemics, bacterial coinfection is a major cause of increased morbidity and mortality. However, the roles host factors in regulating virus (IAV)-triggered remain elusive. Cyclophilin (CypA) an important regulator infection immunity. Here, we show that IAV-induced CypA expression facilitates group Streptococcus (GAS) both vitro vivo. Upon IAV infection, interacts with focal adhesion kinase (FAK) inhibited E3 ligase cCbl-mediated, K48-linked ubiquitination FAK, which...
Abstract. Across the Qinghai–Tibet Plateau (QTP) there is a narrow engineering corridor with widely distributed slopes called Engineering Corridor (QTEC), where variety of important infrastructures are concentrated. These facilities transportation routes for people, materials, energy, etc. from inland China to Tibet Autonomous Region. From Golmud Lhasa, covers 632 km permafrost containing densely developed Railway and Highway, as well power communication towers. Slope failure in regions,...
Abstract Background Porcine proliferative enteropathy caused by Lawsonia intracellularis ( L. ) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports on prevalence of L.intracellularis infection available. The aim current study was estimate seroprevalence antibodies intensive farms China. Results A total 1060 serum samples were collected from 14 commercial located throughout Animals all age groups sampled including...
Abstract Ebola virus (EBOV) is the most virulent pathogens that cause hemorrhagic fever with high mortality rates in humans and nonhuman primates. The postexposure antibody therapies to prevent EBOV infection are considered efficient. However, due poor thermal stability of mammalian antibody, their application tropics has been limited. Here, we developed a thermostable therapeutic against based on chicken immunoglobulin Y (IgY). IgY antibodies demonstrated excellent stability, which retained...
A fluorescent microsphere-based immunochromatographic strip test (FICT) was developed for the rapid, sensitive, and quantitative detection of porcine reproductive respiratory syndrome virus (PRRSV) antibodies at pen-side. The assay based on formation a sandwich immune-complex (anti-pig IgG-PRRSV antibodies-NSP7/N), which validated by comparison with IDEXX-ELISA using 3325 clinical specimens. diagnostic specificity, sensitivity, accuracy FICT were 97.28, 93.41, 94.95%, respectively. showed...
Abstract Safe and effective vaccination is critical to combatting the COVID-19 pandemic. Here, we developed a trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine candidate that simulates natural structure of spike (S) trimer glycoprotein. Immunization with RBD-trimer induced robust humoral cellular immune responses high level neutralizing antibodies were maintained for at least 4 months. Moreover, produced in response effectively neutralized 501Y.V2 variant. Of note, when...