A5089201022- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Asthma and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lymphoma Diagnosis and Treatment
- Apelin-related biomedical research
- Neuroblastoma Research and Treatments
- Eating Disorders and Behaviors
- Adrenal Hormones and Disorders
- Genetics and Physical Performance
- Thyroid Disorders and Treatments
- Children's Physical and Motor Development
- Respiratory and Cough-Related Research
- Obstructive Sleep Apnea Research
- Genetics and Neurodevelopmental Disorders
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
University of Chieti-Pescara
2010-2018
Johns Hopkins University
2011
Johns Hopkins Medicine
2011
University of Parma
2010
University of Milan
2010
Università Cattolica del Sacro Cuore
2010
We aimed at comparing exhaled and non-exhaled non-invasive markers of respiratory inflammation in patients with chronic obstructive pulmonary disease (COPD) healthy subjects define their relationships smoking habit. Forty-eight stable COPD who were ex-smokers, 17 current smokers, 12 smokers ex-smokers included a cross-sectional, observational study. Inflammatory outcomes, including prostaglandin (PG) E2 15-F2t-isoprostane (15-F2t-IsoP) concentrations breath condensate (EBC) sputum...
GH has been suggested to influence the function of immune system in several species. Experimental autoimmune encephalomyelitis (EAE) (an animal model for multiple sclerosis) reported not occur GH-deficient (GHD) mice. The aim this study was elucidate effects and GHRH replacement on development EAE a mouse isolated GHD due removal gene [GHRH knockout (GHRHKO)]. We studied two groups adult female mice: 12 GH-sufficient animals (control) 36 GHRHKO animals. All mice were immunized with myelin...
Mutations in the genes encoding for GHRH receptor (GHRHR) and GH (GH1) are most common cause of familial isolated deficiency (IGHD). GHRHR mutations often associated with anterior pituitary hypoplasia (APH), but this has been reported almost exclusively children older than 8 yr. We analyzed measured size a consanguineous family father three five siblings IGHD.The aim study was to find mutated gene severe IGHD.We sequenced whole coding regions intron-exon boundaries from peripheral DNA index...
Exhaled breath condensate (EBC) 8-isoprostane concentrations are increased in asthma, but it is not known if they acutely change following bronchoprovocation. The objective of this study was to evaluate EBC allergen-induced bronchoprovocation asthma.This comparison included eight mild atopic asthmatics and six controls. Asthmatics were challenged with inhaled specific allergen, methacholine, irrelevant allergen random order. Controls allergen. EBCs collected at 0, 3, 6, 9, 23 hours by the...
15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), non-invasive technique for sampling airway secretions, patients with cystic fibrosis (CF). Azithromycin antioxidant properties experimental models CF, but its effects on stress CF are largely unknown. Primary objective this pilot, proof-of-concept, prospective, parallel group, pharmacological study, was investigating the potential azithromycin as reflected by EBC...
Objective: Adipose tissue produces adiponectin, an anti-inflammatory protein. High systemic total adiponectin is associated with a low risk for incident asthma but the association lung not known. Our objective was to evaluate between sputum and asthma. Methods: This case-control study included 44 cases objectively-confirmed equal number of body mass index (BMI) sex-matched controls. Serum were estimated by ELISA Western Blot technique, respectively. While Fisher's exact test, t-test...
We measured urinary 8-isoprostane (IsoP), a biomarker of oxidative stress, and fractional exhaled nitric oxide (FeNO), airway inflammation, in 8 patients with COPD who were current smokers (COPD CS) (7/1 males/females, age 60±4 yrs, mean±SEM, FEV1 65.8±4.8% pred), 9 ex-smokers ES) (7/2 66±3 FEV 50.6±3.6% 10 1 healthy (HS) (9/1 m/f, 43±4 101.7±3.1% pred). also prostaglandin (PG)E2, that can have proand anti-inflammatory effects, sputum supernatants 6 CS (5/1 60±5 62.9±4.4% 12 ES (10/2 67±2...