A5039542308- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystal Structures and Properties
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Metal complexes synthesis and properties
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Crystal structures of chemical compounds
- Organometallic Compounds Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Polyoxometalates: Synthesis and Applications
- RNA Interference and Gene Delivery
- Advanced Condensed Matter Physics
- Inorganic Chemistry and Materials
- Nanocluster Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Synthesis and Reactivity of Heterocycles
- Sulfur-Based Synthesis Techniques
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Synthesis and Catalytic Reactions
Guangdong Pharmaceutical University
2011-2023
Zhongshan Hospital
2019
Dalian University
2008-2013
Dalian University of Technology
2007-2010
(H(2)en)(2)Cu(8)Sn(3)S(12) contains a trigonal CuS(3)-based framework into which Sn(4+) ions are incorporated, and exhibits multiple channel systems interesting ion-exchange properties.
Two novel framework compounds, Zn(en)3Ag2I4 (1) and Ni(en)3Ag2I4 (2), have been synthesized by a self-assembly reaction. Both of them contain an unexpected framework, Ag2I42− with tridymite topolopy, the discrete M(en)32+ cations are located in channels. Their thermal properties circular dichroism spectra were investigated.
Two copper-rich open-framework sulfides, K(4)Cu(8)Ge(3)S(12) (1) and Rb(4)Cu(8)Ge(3)S(12) (2), have been synthesized under solvothermal conditions. Compounds 1 2 are isostructural contain icosahedral [Cu(8)S(12)](16-) clusters as basic building blocks. These primitive cubic packed connect to one another by discrete Ge(4+) ions generate 3D Cu-Ge-S framework form channels along 100 directions where the alkali metal cations reside. two sulfides crystallize in perovskite structure.
A range of indolizine smoothly underwent visible-light-induced intermolecular [3+2] annulations with internal alkynes to afford pyrrolo[2,1,5-cd]indolizine in good excellent yields high regioselectivity. Through this cascade reaction, a series fluoroactive fused indolizines large π-system were conveniently synthesized. The usage visible light as energy source air stoichiometric oxidant under simple conditions makes process attractive and practical.
G-quadruplexes (G4s) are prevalent in oncogenes and potential antitumor drug targets. However, binding selectivity of compounds to G4s still faces challenges. Herein, we report a platinum(II) complex (Pt1), whose affinity G4-DNA is activated by adaptive controlled kinetics. The resolved structure Pt1/VEGF-G4 (a promoter G4) shows that Pt1 matches 3'-G-tetrad VEGF-G4 through Cl- -dissociation loop rearrangement VEGF-G4. Binding rate constants determined coordination bond breakage/formation,...
Regulating autophagy to control the homeostatic recycling process of cancer cells is a promising anticancer strategy. Golgi apparatus substrate but Golgi-autophagy (Golgiphagy) mediated antitumor pathway rarely reported. Herein, we have developed novel Golgi-targeted platinum (II) complex Pt3, which ca. 20 times more cytotoxic lung carcinoma than cisplatin and can completely eliminate tumors after intratumoral administration in vivo. Its nano-encapsulated system for tail vein also features...
Three framework silver−thioantimonates, K3Ag9Sb4S12(1), Rb3Ag9Sb4S12(2), and Cs3Ag9Sb4S12(3), one layered silver−thioarsenate, CsAg2AsS3(4), have been synthesized solvothermally in the presence of thiophenol as a mineralizer. Compounds 1, 2, 3 are isostructural contain infinite silver−sulfur chains [Ag9S12]15−. These connected to another by antimony atoms generate wide channels along [001] direction where alkali metal cations reside. The structure 4 consists helical [Ag2S3]4− linked arsenic...
Rigid hindered N-heterocyclic carbene palladium complexes have been developed and exhibited high activities for a variety of (hetero)aryl chlorides with (hetero)anilines amines under aerobic conditions.
Two new silver antimony sulfides, KAg2SbS3 (1) and K2Ag3Sb3S7 (2), have been synthesized solvothermally in the presence of thiophenol as a mineralizer. Compound 1 contains hexagonal net formed by condensation Ag2SbS3 six-membered rings. These sheets are linked through Ag−S bonds to obtain double layers. The structure 2 consists infinite [Sb2S4]2− chains [Ag6Sb2S10]∞8− columns form [Sb2S4]∞2− generated vertex-shared SbS33− pyramids, while composed edge-shared SbS3 pyramid, AgS3 triangles,...
A general protocol has been developed for the Buchwald–Hartwig aminations of different kinds electrophiles: aryl esters as acyl electrophiles and chlorides electrophiles.
Abstract A new boron oxide organic open‐framework compound with (H 2 en)Cl as a template was synthesized solvothermally and characterized by various techniques such elemental analysis, IR spectroscopy, X‐ray diffraction, thermogravimetric luminescence. The framework is built up from neutral [B 6 O 9 ] layers linked ethylenediamine molecules through coordinative B–N bonds.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A quasi-cross-shaped platinum(II) compound (L′ 2 LPt) with inhibitory activity against thrombin binds the antiparallel two-G-tetrad G-quadruplex TBA. The NMR structure of Pt–G-quadruplex was solved to reveal this unusual “wall-mounted” binding mode.
A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction imidazo[1,2-a]pyridine has been developed. This strategy provides a broad range substrates represents an efficient approach to give various 2-aminopyridine-decorated in good yields.
Abstract G‐quadruplexes (G4s) are prevalent in oncogenes and potential antitumor drug targets. However, binding selectivity of compounds to G4s still faces challenges. Herein, we report a platinum(II) complex ( Pt1 ), whose affinity G4‐DNA is activated by adaptive controlled kinetics. The resolved structure /VEGF‐G4 (a promoter G4) shows that matches 3′‐G‐tetrad VEGF‐G4 through Cl − ‐dissociation loop rearrangement VEGF‐G4. Binding rate constants determined coordination bond...
Abstract Two different systems were used for syntheses of metal selenides, [Mn(en) 3 ][In 2 Se 5 ] ( 1 ) and [MnSe(en) 0.5 by the reactions In , MnCl selenium powder at 170 °C 6 days. Compound contains a one‐dimensional [In 2– chain propagating along crystallographic c axis separated 2+ complex cations. The anionic is constructed vertex‐linked InSe 4 tetrahedra linked Se–Se bridges four‐membered rings five‐membered [(In 3+ (Se )(Se )] rings. has three‐dimensional network containing monolayer...
Abstract Regulating autophagy to control the homeostatic recycling process of cancer cells is a promising anticancer strategy. Golgi apparatus substrate but Golgi‐autophagy (Golgiphagy) mediated antitumor pathway rarely reported. Herein, we have developed novel Golgi‐targeted platinum (II) complex Pt3 , which ca. 20 times more cytotoxic lung carcinoma than cisplatin and can completely eliminate tumors after intratumoral administration in vivo. Its nano‐encapsulated system for tail vein also...
Abstract Copper(I) complexes, [Cu 2 Cl (phen)] ∞ ( 1 ; phen = 1,10‐phenanthroline), (SCN)(CN)(phen) ] ), and [Cu(SCN)(bipy)] 3 bipy 2,2′‐bipyridine) were synthesized by hydrothermal reduction with tartaric acid as reducing reagent. Compound exhibits μ ‐Cl modes that construct unique Cu six‐membered ring units, which form a one‐dimensional infinite chain structure sharing common edges. Alternating CN – SCN ligands bridge atoms to an helical in compound . consists of split‐stair formed...
A facile photoinduced successive oxidative ring-opening and borylation of indolizines with NHC–boranes via a one-pot method has been unveiled. This photo-promoted strategy enables the formation unsaturated NHC–boryl carboxylates under transition metal-free conditions.
The title compound, [Fe(C2O4)(C5H5N)2], was synthesized via unexpected oxidation of (S,S)-tartaric acid under solvothermal conditions. FeII atom reveals octahedral coordination involving two N atoms pyridine and oxalate groups acting as tetradentate bridging ligands between centres. polyhedra are connected into one-dimensional zigzag chains linked by exo-tetradentate groups.