A5025562404- Thermoregulation and physiological responses
- Ovarian function and disorders
- Heart Rate Variability and Autonomic Control
- Hormonal and reproductive studies
- Exercise and Physiological Responses
- Electrolyte and hormonal disorders
- Sports Performance and Training
- Endometriosis Research and Treatment
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Cardiovascular Health and Disease Prevention
- Sodium Intake and Health
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Menopause: Health Impacts and Treatments
- Neuroendocrine regulation and behavior
- Climate Change and Health Impacts
- Infrared Thermography in Medicine
- Spaceflight effects on biology
- Stress Responses and Cortisol
- Sex and Gender in Healthcare
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Cardiovascular Effects of Exercise
- Hormonal Regulation and Hypertension
Yale University
2016-2025
John B. Pierce Laboratory
2015-2024
Rockefeller University
2020
Princeton University
2020
Federation of American Societies for Experimental Biology
2020
National Institutes of Health
2020
Harvard University
2020
Brigham and Women's Hospital
2020
Cornell University
2020
Norwegian Womens Public Health Association
2018
To determine sex differences in osmoregulation of arginine vasopressin (AVP) and body water, we studied eight men (24 ± 1 yr) women (29 2 during 3% NaCl infusion [hypertonic saline (HSI); 120 min, 0.1 ml · kg wt −1 min ]. Subjects then drank 15 ml/kg over 30 followed by 60 rest. Women were the early follicular (F; 16.1 2.8 pg/ml plasma 17β-estradiol 0.6 ng/ml progesterone) midluteal (L; 80.6 11.4 12.7 0.7 menstrual phases. Basal osmolality was higher F (286 mosmol/kgH O) (289 compared with L...
Abstract The relationship of 11 measures trunk and lower limb flexibility to the economy treadmill walking jogging as measured by steady‐state oxygen consumption (VO 2 ) was studied. Subjects (38 women, 62 men, aged 20–;62 years) were tested at six speeds between 53.6 187.7 m/min. By combining scores from all tests, beginning 107.3 m/min, “tightest” third used significantly less O /m/kg (9%, p < 0.05) than “loosest” third, with “normals” in between. Two rotation turnout, gave best...
To test the hypothesis that progestin-mediated increases in resting core temperature and threshold for sweating onset are counteracted by estrogen, we studied eight women (24 ± 2 yr) at 27°C rest, during 20 min of passive heating (35°C), 40 exercise 35°C. Subjects were tested four times, early follicular midluteal menstrual phases, after 4 wk combined estradiol-norethindrone (progestin) oral contraceptive administration (OC E+P), progestin-only P). The order OC P E+P randomized. Baseline...
To test the hypothesis that estrogen reduces operating point for osmoregulation of arginine vasopressin (AVP), thirst, and body water balance, we studied nine women (25 ± 1 yr) during 150 min dehydrating exercise followed by 180 ad libitum rehydration. Subjects were tested six different times, early-follicular (twice) midluteal menstrual phases after 4 wk combined [estradiol-norethindrone (progestin), OC E + P] norethindrone (progestin only, P) oral contraceptive administration, in a...
To determine if estrogen upregulates osmotic secretion of arginine vasopressin (AVP) and alters body water balance, we infused hypertonic (3% NaCl) saline in 6 women (68 ± 3 yr) after 14 days 17β-estradiol (transdermal patch, ∼0.1 mg/day, E 2 ) placebo (control) administration. Hypertonic was at 0.1 ml ⋅ kg −1 min for 120 min, a 30-min equilibration period, the subjects drank ad libitum 180 min. increased basal plasma estradiol concentration from ≤12 to 80 12 pg/ml AVP (P [AVP] 2.1 0.7 3.1...
Polycystic ovary syndrome (PCOS) is a complex with cardiovascular risk factors, including obesity and insulin resistance. PCOS also associated high androgens, increases the of dysfunction in women. Due to complexity PCOS, had it has been challenging isolate specific causes dysfunction. Our measure (endothelial dysfunction) was most profound lean women PCOS. The endothelin-1-induced vasodilation these subject, dependent on ETB R but not NO-dependent. We demonstrated oestrogen administration...
To determine estrogen effects on osmotic regulation of arginine vasopressin (AVP) and body fluids, we suppressed endogenous progesterone using the gonadotropin-releasing hormone (GnRH) analog leuprolide acetate (GnRHa). Subjects were assigned to one two groups: 1) GnRHa alone, then + (E, n = 9, 25 ± 1 yr); 2) with (E/P, 6, 26 3). During alone treatment, compared AVP fluid regulatory responses 3% NaCl infusion (HSI, 120 min, 0.1 ml · min −1 kg wt ), drinking (30 15 ml/kg wt), recovery (60...
To test the hypothesis that inhibitory action of central blood volume expansion on thirst and renal fluid regulation is attenuated with aging, we monitored drinking responses dehydrated older (70 +/- 2 yr, n = 6) younger (24 1 subjects during 195 min head-out water immersion (HOI), which shifts centrally increases plasma (PV). Subjects by exercising for h at 36 degrees C in evening refraining from fluids overnight before HOI 34 or a seated control perfusion suit [time (TC)] next morning. Ad...
To determine the effect of estrogen and progesterone on plasma volume (PV) extracellur fluid (ECFV), we suppressed endogenous by using gonadotropin-releasing hormone (GnRH) antagonist ganirelix acetate in seven healthy women (22 ± 1 yr). Subjects were administered GnRH for 16 days. Beginning day 5 administration, subjects (E 2 ) 11 days, beginning 12 added -P 4 On days 2, 9, estimated ECFV (inulin washout), transcapillary escape rate albumin (TER alb ), PV (Evans blue dye). Plasma E...
Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises cutaneous microvascular dilation PCOS via the endothelin-1 ET-B subtype receptor. To control isolate testosterone's effects on dilation, we administered a gonadotropin-releasing hormone antagonist (GnRHant) for 11 days obese, otherwise healthy [controls, 22.0 (4) yr, 36.0 (3.2) kg/m(2)] or [23 35.4 (1.3) kg/m(2)], adding (T; 2.5 mg/day) 8-11....
Sex and gender differences in the cardiovascular adaptation to spaceflight were examined with goal of optimizing health safety male female astronauts at forefront space exploration. Female are more susceptible orthostatic intolerance after flight; visual impairment intracranial pressure syndrome predominates slightly males. Since simulates vascular aging, sex-specific effects on endothelium thrombotic risk warrant examination as predisposing factors atherosclerosis, important current cohort...
Abstract Context Transgender men (TGM) are persons assigned female gender at birth with a male identity and routinely treated testosterone. Androgen excess is associated endothelial dysfunction among cisgender females (CGF) an early sign of atherosclerosis hypertension. Objective To determine the effect testosterone treatment on function in TGM. Setting The John B. Pierce Laboratory Yale School Medicine. Subjects Eleven TGM (age 27 ± 5 years; BMI 24.4 3.7 kg/m 2 ) receiving (T) 20 CGF (28...