A5103268306- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Electrolyte and hormonal disorders
- Environmental Justice and Health Disparities
- Ion Transport and Channel Regulation
- Vitamin C and Antioxidants Research
- Neuropeptides and Animal Physiology
- Effects and risks of endocrine disrupting chemicals
- Wildlife Ecology and Conservation
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Toxic Organic Pollutants Impact
- Botanical Research and Chemistry
- Retinoids in leukemia and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Scarabaeidae Beetle Taxonomy and Biogeography
- Heavy Metal Exposure and Toxicity
- Marine Toxins and Detection Methods
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Essential Oils and Antimicrobial Activity
- Ion channel regulation and function
- Vitamin K Research Studies
Midwestern University
1999-2021
National Agency for National Parks
2010-2021
University of North Carolina at Chapel Hill
2021
North Carolina State University
2021
University of Michigan
2021
Magyar Agrár- és Élettudományi Egyetem
2021
Tufts University
2021
University of Bahrain
2015
Instituto de Ecología
2006-2010
Beaumont Hospital, Royal Oak
2004
Cadmium (Cd) is a nephrotoxic environmental pollutant that causes generalized dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though effects Cd on kidney have been well-characterized, molecular mechanisms underlying these not fully elucidated. MicroRNAs (miRNAs) are small non-coding RNAs regulate cellular physiologic function modulating gene expression at post-transcriptional level. The goal present study was to determine if affects renal cortex miRNA in...
ABSTRACT The cadherin/catenin complex serves as an important structural component of adherens junctions in epithelial cells. Under certain conditions, β-catenin can be released from this and interact with transcription factors the nucleus to stimulate expression genes that regulate apoptosis cell cycle control. While studying effects bacterial pathogen Chlamydia trachomatis on human cervical cells culture, we observed C. caused separate each other without detaching their growing surface....
The chromosomal location of CUL-5 (11q 22-23) is associated with LOH in breast cancer, suggesting that may be a tumor suppressor. purpose this research was to determine if there differential expression epithelial cells versus cancer cell lines, and normal human tissues tumors. (HMEC, MCF-10A), (MCF-7, MDA-MB-231) examined using RT-PCR, Northern blot analysis, Western analysis. mRNA for other CUL family members (CUL-1, -2, -3, -4A, -4B) these evaluated by RT-PCR. A tissue array profiling were...
Several K+ conductances have been identified in the kidney, with specific properties and localization distinct cell types membrane domains. On other hand, several channels characterized at molecular level. By immunolocalization, we show that a new inward rectifying channel, TWIK-1, is specifically expressed tubular segments of rat kidney. In proximal tubule, TWIK-1 prevails initial portions (convoluted part), where it restricted to apical (brush-border) membrane. collecting duct,...
We have previously provided evidence that an autocrine loop involving vasopressin is present in perhaps all breast cancers. This study now shows MCF-7 cancer cells express mRNAs for currently recognized receptor subtypes (V1a, V1b, and V2). Cloning DNA sequencing over the entire open reading frame of each mRNA revealed normal sequences representing were present. However, addition, abnormal V2 receptor, expected to give rise a truncated 'diabetic' protein, was also expressed. Western analysis...
Studies using fetal sheep, goats, and guinea pigs indicate that vasopressin may play a role in preparing the lung for transition from uterine to an air-breathing environment by slowing liquid secretion. The mechanism of action is believed occur through V2 receptors with subsequent activation amiloride-sensitive sodium channels. However, presence receptor human has not yet been documented. In present study, expression adult was examined reverse transcription-polymerase chain reaction...
By dispersing seeds long distances, large, fruit-eating animals influence plant population spread and community dynamics. After fruit consumption, animal gut passage time movement determine seed dispersal patterns distances. These, in turn, are influenced by extrinsic, environmental variables intrinsic, individual-level variables. We simulated forest elephants ( Loxodonta cyclotis ) integrating data from wild with 96 individuals. On average, dispersed 5.3 km, 89% of farther than 1 km. The...
The excitatory amino acid domoic is the causative agent of amnesic shellfish poisoning in humans. vitro effects on rat neonatal brain microglia were compared with E. coli lipopolysaccharide (LPS), a known activator mediator release over 4 to 24 hour observation period. LPS [3 ng/mL] but not [1 mM] stimulated statistically significant increase TNF-alpha mRNA and protein generation. Furthermore, both did significantly affect TGF-beta1 gene expression release. Finally, an exposure resulted...
Reconnaissance surveys were made of the forests four central African countries to establish, for first time, status forest-dwelling elephants. The results, when combined with information from previous in other countries, provide a picture elephant situation forest zone, and especially impact poaching. About one-third population Africa is be found Zaire, about Gabon. rest are Cameroon, Central Republic, Equatorial Guinea, Congo. It poaching ivory, rather than growth human populations, which...
In order to understand the role of p53 tumor suppressor gene in microRNA expression during osteoblast differentiation, we used a screen identify microRNAs that were altered p53-dependent manner. MicroRNAs from MC3T3-E1 preosteoblasts isolated day 0 (undifferentiated) and 4 (differentiating) compared deficient line treated similarly. Overall, one fourth all tested showed reduction 0.6 fold, similar number them increased 1.7 fold with differentiation. P53 deficiency caused 40% differentiating...