A5005682177- Platelet Disorders and Treatments
- Blood properties and coagulation
- Blood groups and transfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammatory Biomarkers in Disease Prognosis
- Entomological Studies and Ecology
- Complement system in diseases
- Cellular transport and secretion
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Insect and Pesticide Research
- Biomarkers in Disease Mechanisms
- Cell Adhesion Molecules Research
- Autoimmune Bullous Skin Diseases
- Toxin Mechanisms and Immunotoxins
Erasmus MC
2019-2023
Rotterdam University of Applied Sciences
2022
Erasmus University Rotterdam
2018
Wellcome Centre for Cell-Matrix Research
2018
University of Manchester
2018
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder that characterized by low platelet count and increased bleeding risk. COVID-19 vaccination has been described as a risk factor for de novo ITP, but the effects of in patients with ITP are unknown. We aimed to investigate on count, complications, exacerbation (≥50% decline or nadir < 30 × 109/L >20% decrease from baseline, use rescue therapy). Platelet counts healthy controls were collected immediately before 1 4 weeks after...
Abstract Retinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), condition that leads to loss central vision. The deposition acute phase pentraxin C-reactive protein (CRP) macula activates complement system, thereby contributing dysregulated inflammation. factor H (FH) can bind CRP and down-regulate an inflammatory response. However, it is not known whether truncated form FH, called H-like 1 (FHL-1), which significant regulatory eye, also interacts...
Von Willebrand factor (VWF) and VWF propeptide (VWFpp) are stored in eccentric nanodomains within platelet alpha-granules. VWFpp can undergo differential secretion following Weibel-Palade body exocytosis endothelial cells; however, it is unclear if the same process occurs during alpha-granule exocytosis. Using a high-throughput 3-dimensional super-resolution imaging workflow for quantification of individual cargo, we studied cargo release response to different physiological stimuli.To...
Coronavirus disease 19 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can be associated changes in platelet count [1, 2]. Thrombocytopenia has been reported up to 40% of COVID-19 infections [3-5] and is an important marker for morbidity mortality 2, 5]. Hence, monitoring counts diagnosis treatment patients. a result the itself (septicaemia), diffuse intravascular coagulation (DIC), medication or COVID-19-associated immune thrombocytopenic...
Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) qualitative 2A/2B/2M/2N) defects of circulating von factor (VWF). Circulating VWF levels not always fully explain phenotypes, suggesting role for alternative factors, like platelets. Here, we investigated platelet 4 (PF4) in large cohort patients with VWD. PF4 were lower type 2B and current phenotype was significantly associated higher levels, particularly Based on our findings speculate that...
Lowe syndrome (LS) is a rare, X-linked disorder characterised by numerous symptoms affecting the brain, eyes, and kidneys. It caused mutations in oculocerebrorenal of (OCRL) protein, 5-phosphatase localised different cellular compartments that dephosphorylates phosphatidylinositol-4,5-bisphosphate into phosphatidylinositol-4-monophosphate. Some patients with LS also have bleeding disorders, normal to low platelet (PLT) count impaired PLT function. However, mechanism dysfunction not...
Abstract Background Platelet alpha-granules contain Von Willebrand factor (VWF), which is stored in eccentric alpha-granule nanodomains, and VWF propeptide (VWFpp). Differential release of VWFpp has been reported from endothelial cells. It unclear if this also occurs during platelet exocytosis. We have recently developed a 3D super-resolution imaging workflow for quantification content based on Structured Illumination Microscopy (SIM). With we can study cargo following activation hundreds...