A5031684255- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Alzheimer's disease research and treatments
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Urological Disorders and Treatments
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Silk-based biomaterials and applications
- Bladder and Urothelial Cancer Treatments
- Computational Drug Discovery Methods
- Hormonal Regulation and Hypertension
- Advanced Proteomics Techniques and Applications
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Muscle Physiology and Disorders
Nationwide Children's Hospital
2021-2024
University of Colorado Boulder
2017
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression, leading progressive motor and cardiorespiratory function. Four exon-skipping approaches using antisense phosphorodiamidate morpholino oligomers (PMOs) have been approved by FDA restore DMD open reading frame, resulting in expression functional but internally deleted protein, patients with single-exon duplications, exon skipping has potential full-length expression....
Urothelium forms a distensible yet impermeable barrier, senses and transduces stimuli, defends the urinary tract from mechanical, chemical, bacterial injuries. Biochemical genetic labeling studies support existence of one or more progenitor populations with capacity to rapidly regenerate urothelium following injury, but slow turnover, low mitotic index, inconsistent methodologies obscure identity. The properties basal keratin 5 urothelial cells (K5-UCs) have been previously investigated,...
Urinary tract obstruction (UTO) is a common cause of kidney injury that can result in chronic disease and end-stage renal disease. Heterogeneity the extent obstructive damage humans with UTO implies existence unknown mechanisms protect against or accelerate injury. Prior studies show congenital acquired initiate conserved, protective program urothelium remodeling culminates expansion uroplakin (UPK)+ cells to promote structural integrity. However, cellular molecular regulate UPK expression...
Intro/abstract Alzheimer’s disease (AD), a condition characterized by cognitive deficits and progressive loss of memory, is causally linked to the short amyloid peptide Aβ42, which disrupts normal neurotransmission 1,2 . Neurotransmitter (NT) release from synaptic vesicles (SV) requires coordinated binding conserved core secretory machinery comprised soluble NSF attachment protein receptor (vSNARE) synaptobrevin 2 (VAMP2) on SV cognate tSNAREs plasma membrane. Synaptophysin (SYP) most...
Abstract We have employed label-free quantitative proteomics of wild-type and Alzheimer’s disease (AD) model mice synaptosomes to investigate proteomic changes occurring during AD progression as a prelude analysis in humans. More than 4000 proteins were analyzed using multiple tools statistical criteria. Pathway enrichment identified numerous pathways consistent with the current knowledge base, including dysregulation Glutamate Receptor Signaling, Synaptic Long Term Potentiation Depression,...
Journal of the American Society Nephrology 32(10S):p 611-612, October 2021. | DOI: 10.1681/ASN.20213210S1611d