A5008395814- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Liver Diseases and Immunity
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Virus-based gene therapy research
- Lipid metabolism and disorders
- Viral Infections and Outbreaks Research
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
Hôpital de la Croix-Rousse
2018-2023
Université Claude Bernard Lyon 1
2023
Hospices Civils de Lyon
2018-2022
Centre de Recherche en Cancérologie de Lyon
2018
Sapienza University of Rome
2011-2017
We previously reported that Toll-like receptor 9 (TLR9)-CpG oligonucleotides could inhibit the establishment of hepatitis B virus (HBV) infections in hepatocytes. Our aim was to uncover underlying mechanisms this inhibition. HepaRG cells, RPMI-B lymphoblastoma and primary plasmacytoid dendritic cells (pDCs) exposed HBV TLR9 ligands/agonists various configurations were used. observed an inhibition infection upon stimulations only when agonist applied during inoculation. This independent...
NAFLD (non-alcoholic fatty liver disease) reaches an high prevalence in the general population, and it is closely related to metabolic syndrome (MetS). The entity of abnormalities chronic inflammation seem play a main role development fibrosis. aim our study determine whether subjects with MetS have higher fibrosis degree when compared without MetS, investigate relations between fibrosis, its single components inflammation.We considered 24 patients NAFLD. Those who had viral- alcohol-...
Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and associated high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated potential circulating microRNAs diagnose bacterial predict survival cirrhotic AD. High throughput profiling was performed using Nanostring technology 57 AD 24 compensated (CC). Circulating miRs showed that: (a) differentially detected vs. CC were...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Abstract Background The amount of HBV RNA in peripheral blood may reflect covalently closed circular DNA (cccDNA) transcriptional activity within infected hepatocytes. Quantification circulating (cirB-RNA) is thus a promising biomarker for monitoring antiviral treatment. Objectives We evaluated the performance an automated, prototype quantitative assay use on Roche cobas ® 6800/8800 systems. Study Design sensitivity, specificity, linearity, and potential interference by were assessed using...