A5000186443- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Pluripotent Stem Cells Research
- Elasticity and Material Modeling
- Connective tissue disorders research
- Cellular Mechanics and Interactions
- Cardiac Valve Diseases and Treatments
Stanford University
2021-2023
Heart disease is the leading cause of death globally, and delivery therapeutic cargo a promising treatment. However, retention very low. Injectable gels may help improve cargo.
Abstract Three‐dimensional cell encapsulation has rendered itself a staple in the tissue engineering field. Using recombinantly engineered, biopolymer‐based hydrogels to encapsulate cells is especially promising due enhanced control and tunability it affords. Here, we describe detail synthesis of our hyaluronan (i.e., hyaluronic acid) elastin‐like protein (HELP) hydrogel system. In addition validating efficacy synthetic process, also demonstrate modularity HELP Finally, show that can be...
Abstract Cervical damage is the most prevalent type of spinal cord injury clinically, although few preclinical research studies focus on this anatomical region injury. Here we present a combinatorial therapy composed custom-engineered, injectable hydrogel and human induced pluripotent stem cell (iPSC)-derived deep cortical neurons. The biomimetic has modular design that includes protein-engineered component to allow customization cell-adhesive peptide sequence synthetic polymer gel...
Abstract Heart disease is the leading cause of death globally, and delivery therapeutic cargo ( e.g. cells, proteins, drugs) through direct injection into myocardium a promising clinical intervention. However, retention deliverables to contracting low, with as much 60 - 90% payload being lost within 24 hours. Commercially-available injectable hydrogels, including Matrigel, have been hypothesized increase retention, but not yielded significant improvements in quantified analyses. Here, we...