A5100608922- Bioactive Natural Diterpenoids Research
- Crystal structures of chemical compounds
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Marine Sponges and Natural Products
- Acute Ischemic Stroke Management
- Quinazolinone synthesis and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Head and Neck Surgical Oncology
- Nematode management and characterization studies
- Stroke Rehabilitation and Recovery
- Fetal and Pediatric Neurological Disorders
- T-cell and B-cell Immunology
- Synthetic Organic Chemistry Methods
- MicroRNA in disease regulation
- Crystallography and molecular interactions
- Teratomas and Epidermoid Cysts
- Immune Cell Function and Interaction
- Cystic Fibrosis Research Advances
- Gallbladder and Bile Duct Disorders
- Plant-based Medicinal Research
- Endometriosis Research and Treatment
Qingdao University of Science and Technology
2012-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Qingdao University of Technology
2025
Lanzhou University
2020-2024
Vertex Pharmaceuticals (United States)
2023-2024
Heilongjiang University of Chinese Medicine
2024
Southern Medical University
2023
Hainan Medical University
2023
Guangdong Provincial People's Hospital
2023
The first total synthesis of the Euphorbia diterpenoid pepluacetal is disclosed in both racemic and chiral fashions. strategically relies on a photo-induced Wolff rearrangement/lactonization cascade (WRLC) reaction to access cyclobutane moiety, ring-closing metathesis/cyclopropanation sequence rapidly forge 7-3 bicyclic system, late-stage Rh-catalyzed transannular carbenoid insertion C(sp
Abstract Background: Severe stroke has high rates of mortality and morbidity. This study aimed to investigate the clinical course, causes worsening, outcomes severe ischemic stroke. Methods: prospective, multicenter cohort enrolled adult patients admitted ≤30 days after from nine hospitals in China between September 2017 December 2019. was defined as a score ≥15 on National Institutes Health Stroke Scale (NIHSS). Clinical worsening an increase 4 NIHSS baseline. Unfavorable functional outcome...
Abstract The first total synthesis of the Euphorbia diterpenoid pepluanol B in both racemic and enantioenriched form involves 20 steps from a known bicyclic diol. This features an unprecedented bromo‐epoxidation to control eight‐membered‐ring conformation. In addition, salient reactions for construction tetracyclic backbone include sterically challenging aldol reaction establish quaternary center, ring closing metathesis (RCM) forge eight‐membered ring, diastereoselective cyclopropanation...
Pepluanol B is a new
Conformational flexibility and<sup>sp2</sup>CH⋯Cl hydrogen bond lead to three polymorphs of 4-chloro-phenylanthranilic acid.
A series of title compounds 2 were efficiently synthesized via the condensation 1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone oxime with various asymmetric thiophosphoryl chlorides in sodium hydroxide powder and acetonitrile system. The structures confirmed by IR, 1H NMR, 31P EI-MS, elemental analysis. results preliminary bioassays indicated that possessed good to moderate insecticidal activity against aphides at dosage 250 mg/L, some them exhibited fungicidal activities concentration 100 mg/L.
The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis ankylosing spondylitis. However, the association studies between multiple sclerosis (MS) SNPs IL12B or IL23R reported inconsistent results in Caucasian population. These discrepancies prompted us investigate whether variants are susceptibility MS Chinese southern In this study, we...
Abstract The first total synthesis of the Euphorbia diterpenoid pepluanol B in both racemic and enantioenriched form involves 20 steps from a known bicyclic diol. This features an unprecedented bromo‐epoxidation to control eight‐membered‐ring conformation. In addition, salient reactions for construction tetracyclic backbone include sterically challenging aldol reaction establish quaternary center, ring closing metathesis (RCM) forge eight‐membered ring, diastereoselective cyclopropanation...
The purpose of this study was to evaluate the outcome endovascular management iatrogenic vascular injuries (IVIs). We retrospectively reviewed clinical records 19 consecutive patients who underwent therapy IVIs. Endograft implantation conducted in 13 patients, intravascular embolization using coil performed four combined treatment involving balloon intervention and percutaneous thrombin injection done one patient remaining received compression for hemostasis. There were no deaths after...
Abstract A series of pyrazolo[4,3‐ e ]‐1,2,4‐triazolo‐[1,5‐ c ]pyrimidine derivatives, bearing phosphonylbenzyl chain in position 7, were conveniently synthesized an attempt to obtain potent and selective antagonists for the 2 adenosine receptor or pesticide lead compounds. Diethyl[(5‐amino‐4‐cyano‐3‐methylsulfanyl‐pyrazol‐1‐yl)‐benzyl]phospho‐nate ( 3 ), which was prepared by cyclization diethyl 1‐hydrazinobenzylphosphonate 1 ) with 2‐[bis(methylthio)methylene]malononitrile reacted triethyl...
Abstract Ion channels, in particular transient–receptor potential (TRP) are essential genes that play important roles many physiological processes. Emerging evidence has demonstrated TRP involved a number of diseases, including various cancer types. However, we still lack knowledge about the expression alterations landscape across In this review, comprehensively reviewed and summarised transcriptomes from more than 10 000 samples 33 We found were widespreadly transcriptomic dysregulated...