A5079853314- Gene expression and cancer classification
- Ultrasound in Clinical Applications
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Radiation Dose and Imaging
- Vascular Malformations and Hemangiomas
- Shoulder Injury and Treatment
- Atomic and Subatomic Physics Research
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Genetic and phenotypic traits in livestock
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Tumors and Oncological Cases
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Advanced X-ray and CT Imaging
- Gastrointestinal disorders and treatments
- Neonatal Respiratory Health Research
- Hernia repair and management
- Radiology practices and education
- Genomics and Chromatin Dynamics
University of California, San Francisco
2016-2024
Universitetshospitalernes Center for Sundhedsfaglig Forskning
2024
University of California System
2021-2023
UCSF Benioff Children's Hospital
2016-2022
UCSF Helen Diller Family Comprehensive Cancer Center
2021
Harvard University
2016-2017
Boston Children's Hospital
2016-2017
University of California, Los Angeles
2015
University of California, San Diego
2007-2015
VA San Diego Healthcare System
2012
Little is known about how the human brain differs from that of our closest relatives. To investigate genetic basis specializations in organization and cognition, we compared gene expression profiles for cerebral cortex humans, chimpanzees, rhesus macaques by using several independent techniques. We identified 169 genes exhibited differences between chimpanzee cortex, 91 were ascribed to lineage as an outgroup. Surprisingly, most brains humans non-human primates involved up-regulation, with...
A fundamental step in the analysis of gene expression and other high-dimensional genomic data is calculation similarity or distance between pairs individual samples a study. If one has collected N total assayed level G genes on those samples, then an x matrix can be formed that reflects correlation with respect to values over genes. This examined for patterns via standard reduction cluster techniques. We consider alternative conventional analyses matrices rooted traditional linear models....
The current model to explain the organization of mammalian nervous system is based on studies anatomy, embryology, and evolution. To further investigate molecular adult brain, we have built a gene expression-based brain map. We measured expression patterns for 24 neural tissues covering mouse central found, surprisingly, that bears transcriptional "imprint" consistent with both embryological origins classic evolutionary relationships. Embryonic cellular position along anterior-posterior axis...
Arteriovenous malformations (AVMs) have recently been reported to a high incidence of somatic KRAS mutations suggesting potential for treatment with mitogen-activated protein kinase inhibitors. In this case report, we describe genotype-targeted mutant metameric AVM in patient Cobb syndrome using the inhibitor trametinib. Therapeutic response was monitored phase-contrast magnetic resonance angiography quantify arterial inflow as an imaging biomarker. Treatment trametinib resulted substantial...
Multivariate distance matrix regression (MDMR) analysis is a statistical technique that allows researchers to relate P variables an additional M factors collected on N individuals, where P>>N. The can be applied number of research settings involving high dimensional data types such as DNA sequence data, gene expression microarray and imaging data. MDMR involves computing the between all pairs individuals with respect interest constructing x whose elements reflect these distances. Permutation...
To evaluate the feasibility of constructing radiogenomic-based surrogates molecular assays (SOMAs) in patients with clear-cell renal cell carcinoma (CCRCC) by using data extracted from a single computed tomographic (CT) image.In this institutional review board approved study, gene expression profile and contrast material-enhanced CT images 70 CCRCC training set were independently assessed two radiologists for predefined imaging features. A SOMA previously validated CCRCC-specific supervised...
Abstract Background Clinical, molecular, and histopathologic features guide treatment for neuroblastoma, but obtaining tumor tissue may cause complications is subject to sampling error due heterogeneity. We hypothesized that image‐defined risk factors (IDRFs) would reflect molecular features, histopathology, clinical outcomes in neuroblastoma. Methods performed a retrospective cohort study of 76 patients with neuroblastoma or ganglioneuroblastoma. Diagnostic CT scans were reviewed 20 IDRFs,...
Expression quantitative trait locus (eQTL) mapping is used to find loci that are responsible for the transcriptional activity of a particular gene. In recent eQTL studies, expression profiles were derived from either homogenized whole brain or collections large regions. However, very heterogeneous organ, and different regions vary significantly. Because importance potential power studies in identifying regulatory networks, we analyzed gene patterns multiple inbred mouse strains investigated...
Hypoxia is a hallmark of respiratory, neurological, or hematological diseases as well life at high altitude. For example, chronic constant hypoxia (CCH) occurs in lung altitude, whereas intermittent (CIH) such sleep apnea sickle cell disease. Despite the fact that conditions are frequent, cellular and molecular mechanisms underlying effect hypoxia, whether intermittent, not understood. In this study, we first determined CCH CIH on global gene expression different regions mouse brain using...
The NCCN Guidelines for Wilms Tumor focus on the screening, diagnosis, staging, treatment, and management of tumor (WT, also known as nephroblastoma). WT is most common primary renal in children. Five-year survival more than 90% children with all stages favorable histology who receive appropriate treatment. All patients should be managed by a multidisciplinary team experience managing tumors; consulting pediatric oncologist strongly encouraged. Treatment includes surgery, neoadjuvant or...
In pediatric imaging, sedation is often necessary to obtain diagnostic quality imaging. We aim quantify patient and imaging-specific factors associated with successful scans without anesthesia evaluate labor cost savings our institutional Scan Without Anesthesia Program (SWAP).Patients who participated in SWAP between 2019-2022 were identified. Chart review was conducted sociodemographic clinical information. Radiology database used scan duration, modality/body part of examination,...
Three-dimensional UTE MRI has shown the ability to provide simultaneous structural and functional lung imaging, but it is limited by respiratory motion relatively low parenchyma SNR. The purpose of this paper improve imaging using a phase-resolved reconstruction approach, named motion-compensated low-rank (MoCoLoR), which directly incorporates compensation into constrained model for highly efficient use acquired data.
Both iron deficiency and excess are detrimental in many organisms, previous studies both mice humans suggest that genetic variation may influence status mammals. However, these factors not well defined. To address this issue, we measured basal liver levels 18 inbred strains of sexes on a defined diet found ∼4-fold males (lowest 153 μg/g, highest 661 μg/g) ∼3-fold females 222 658 μg/g). We carried out genome-wide association mapping to identify haplotypes underlying differences three other...
The use of mouse blood as a model for human is often considered in the development clinically relevant, gene expression-based disease biomarkers. However, ability to derive biologically meaningful insights from microarray-based expression patterns whole blood, hindered by high levels globin mRNA. In order characterize effects reduction on peripheral we performed set enrichment analysis genes identified expressed via genome-wide transcriptome analysis. Depletion mRNA enhanced quality...
10526 Background: Pro-angiogenic factors may represent therapeutic targets in sarcoma. Preclinical studies have demonstrated a potential additive or synergistic interaction between anti-angiogenic agents and chemotherapy. The purpose of this study was to determine the maximum tolerated dose (MTD), toxicities, pharmacokinetic (PK) pharmacodynamics (PD) effects PAZIT patients with advanced Methods: Patients 6-30 years age relapsed/refractory sarcomas were eligible. In initial escalation plan...