A5039753412- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- HIV Research and Treatment
- Vector-Borne Animal Diseases
- Pituitary Gland Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Veterinary Oncology Research
- Growth Hormone and Insulin-like Growth Factors
- Microbial infections and disease research
- T-cell and Retrovirus Studies
- Oral and Maxillofacial Pathology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Neurological diseases and metabolism
- Animal Virus Infections Studies
- Cancer and Skin Lesions
- Adrenal Hormones and Disorders
- Renal and related cancers
- Virology and Viral Diseases
- Diphtheria, Corynebacterium, and Tetanus
- Streptococcal Infections and Treatments
- Advanced Radiotherapy Techniques
- Clostridium difficile and Clostridium perfringens research
- Autopsy Techniques and Outcomes
Psychiatry Baselland
2021-2024
Roche (Switzerland)
2024
Universidad de León
2009-2022
Willows Veterinary Centre and Referral Service
2021
University of Nottingham
2016-2018
Instituto de Investigación en Recursos Cinegéticos
2012
Servicio Regional de Investigación y Desarrollo Agroalimentario
2012
Consejo Superior de Investigaciones Científicas
2012
(1) Background: Proton minibeam radiation therapy (pMBRT) is a new radiotherapy technique using spatially modulated narrow proton beams. pMBRT results in significantly reduced local tissue toxicity while maintaining or even increasing the tumor control efficacy as compared to conventional small animal experiments. In all experiments performed up date bearing animals, dose was delivered one single fraction. This first assessment on impact of temporal fractionation scheme response...
Although louping ill affects mainly sheep, a 2011 outbreak in northern Spain occurred among goats. Histopathologic lesions and molecular genetics identified new strain of virus, 94% identical to the from Britain. Surveillance is needed minimize risk domestic wildlife species humans.
Abstract Background A central nervous system (CNS) disease outbreak caused by small ruminant lentiviruses (SRLV) has triggered interest in Spain due to the rapid onset of clinical signs and relevant production losses. In a previous study on this outbreak, role LTR tropism was unclear env encoded sequences, likely involved tropism, were not investigated. This aimed analyze heterogeneity SRLV Env regions - TM amino terminal SU V4, C4 V5 segments order assess virus compartmentalization CNS....
A new condition causing significant economic losses due to lesions in the pectoralis major muscle of commercial broiler chickens has been recently reported Finland.The named wooden breast and is characterized by its gross histological appearance.Between October 2014 April 2015, samples from 5 muscles downgraded slaughterhouse were submitted Veterinary Pathology Service University Nottingham for examination.All five studied showed moderate or severe multifocal polyphasic muscular degeneration...
(1) Background: among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhancement effect. However, pioneering clinical use in 1970s was halted severe side effects. The aim this work provide a first proof that combination ions with minibeam radiation therapy leads minimization toxicities and, thus, opening door renewed therapy; (2) Methods: mouse legs were irradiated either Ne MBRT...
With the exception of classic functional adenomas in dogs and horses, pituitary lesions are infrequently described veterinary literature. Approximately 10% glands from asymptomatic humans contain abnormalities, but equivalent proportion small animals is unknown. Pituitary 136 65 cats collected during routine necropsies were examined to determine prevalence their histopathological diagnosis. Lesions characterized sections stained with hematoxylin eosin, periodic acid-Schiff (PAS), Gordon...
Abstract Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected neurological disease, pneumonia arthritis were used to analyse mannose receptor (MR) expression (transcript levels) proviral load in virus target tissues (lung, mammary gland, CNS carpal joints). Control SRLV-seropositive asymptomatic ( n = 3), seronegative 3) chronic listeriosis, pseudotuberculosis parasitic cysts 1 each case). MR increased the severity...
Clostridium sordellii is found in the environment and occasionally animal (including human) intestines may cause myonecrosis large outbreaks of enterotoxemia. A few cases fatal clostridial infection bears (Ursus spp.) have been described worldwide but none attributed to C. sordellii. We describe a case septicemia caused by an illegally trapped brown bear arctos). At necropsy, acute gangrenous myositis was primary lesion. Serohemorrhagic edema observed abdominal cavity, thorax, pericardium,...
Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, persistent diseases sheep goats. Monitoring the genetic diversity of SRLVs is useful to improve diagnostic tools used eradication programs. In this study, detected Spanish Assaf with different grades lymphoproliferative mastitis were sequenced. Genetic characterization showed that most samples belonged type A closer SRLV isolates previously classified as A2/A3. Four subtype B2 higher...
In order to characterize the complete range of lesions, especially minimal, affecting mammary gland and viral antigen distribution target cells using immunohistochemistry in naturally Visna/maedi (VM) 84 infected sheep were studied, forty-four from flocks with clinical cases (A) 35 randomly sampled two abattoirs (B) together five negative controls (C). An immunocytochemistry technique was developed further milk samples (n = 39) used study excretion, carrier role colostrum transmission...
Recently, the number of clinical reports growing pigs showing neurological signs possibly related to viral infections has increased. The objective this report was describe two outbreaks an atypical condition observed in 6- 7-week-old with a morbidity 20% and fatality rate 60% unrelated farms same company. During acute phase disease, fever, sudden death, signs, ear necrosis occasional corneal opacity were observed. Histopathological examination revealed interstitial pneumonia, lymphoid...
Abstract Background p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation it usually occurs in cutaneous malignancies. Mutant detected by immunohistochemistry because more stable than wild-type p53. However, post-translational modifications response to ultraviolet radiation are important mechanisms stabilization, leading positive staining absence mutation. The aims were: 1) analyze immunohistochemical expression and phospho-p53 Serine 392 canine skin...
A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3-L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7-T8 vertebrae. The improved conservative management but deteriorated 3 months later. Repeated showed meningeal enhancement same and musculature extending right thoracic wall pleural space short tau inversion recovery images. Thoracic CT mineralised lesions...
A 6‐year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized lesion to the forebrain hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) brain revealed rounded, well‐defined, suprasellar central mass. The mass slightly hyperintense cortical grey matter on T2‐weighted (T2W), hypointense T1‐weighted (T1W) images without T2* signal void. There fusiform enhancement after contrast...
In autumn 2011, a disease outbreak caused by Spanish goat encephalitis virus (SGEV) was reported in herd of goats from Asturias (north-western Spain), expanding the known geographic distribution tick-borne Europe. The classified as new subtype (subspecies) within Louping-ill species mammalian flavivirus group. aims present study were to describe pathology naturally infected with SGEV, well discuss pathogenesis that outbreak. A total 22/85 (25.88%) (20 adults and 2 kids) died between October...