A5007821259- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Radioactive element chemistry and processing
- Advanced MRI Techniques and Applications
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Radiopharmaceutical Chemistry and Applications
- Probiotics and Fermented Foods
- Cannabis and Cannabinoid Research
- Medical Imaging Techniques and Applications
- Biological and pharmacological studies of plants
- Alkaloids: synthesis and pharmacology
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Essential Oils and Antimicrobial Activity
- Neuroscience and Neuropharmacology Research
- Metal complexes synthesis and properties
- thermodynamics and calorimetric analyses
- Biochemical and biochemical processes
- Antibiotics Pharmacokinetics and Efficacy
- E-Government and Public Services
- Privacy, Security, and Data Protection
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2010-2024
Istituto di Farmacologia Traslazionale
2014
Wroclaw Medical University
2012
Abstract Unprecedented fast and efficient complexation of Sc III was demonstrated with the chelating agent AAZTA (AAZTA=1,4‐bis(carboxymethyl)‐6‐[bis(carboxymethyl)]amino‐6‐methylperhydro‐1,4‐diazepine) under mild experimental conditions. The robustness 44 Sc(AAZTA) − chelate conjugated biomolecules thereof is further shown by in vivo PET imaging healthy tumor mice models. new results pave way towards development Sc‐based radiopharmaceuticals using chelator.
Spurred by a growing interest in cannabidiolquinone (CBDQ, HU-313, 2) as degradation marker and alledged hepatotoxic metabolite of cannabidiol (CBD, 1), we performed systematic study on the oxidation CBD (1) to CBDQ (2) under variety experimental conditions (base-catalyzed aerobic oxidation, with metals, hypervalent iodine reagents). The best results terms reproducibility scalability were obtained λ5-periodinanes (Dess-Martin periodinane, 1-hydroxy-1λ5,2-benziodoxole-1,3-dione (IBX), SIBX,...
OBETA, you bet: Thermodynamic and kinetic measurements show an apparent paradox. The stability of complexes lanthanide trivalent ions is higher with the heptadentate ligand OBETA (ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid) than its octadentate homologue EGTA (2,2′-oxybis(ethylamine)-N,N,N′,N′-tetraacetic acid). unusual properties Gd(OBETA)− (see structure), combined presence two fast exchanging coordinated water molecules, candidates this complex as MRI contrast...
The heptadentate ligand OBETA (2,2′-oxybis(ethylamine)-N,N,N′,N′-tetraacetic acid) was reported to form complexes with Ln3+ ions more stable than those formed by the octadentate and popular congener EGTA (ethylene glycol O,O′-bis(ethylamine)-N,N,N′,N′-tetraacetic acid). structural features leading this puzzling coordination paradox were investigated X-ray diffraction, solution state NMR, molecular modeling, relaxometric studies. stability constant of Gd(OBETA) (log KGdL = 19.37, 0.1 M KCl)...
Abstract Molecular imaging relies on the availability of probes designed to modify their efficiency in presence a specific parameter, among which pH is one most investigated. Introduction an aminoethyl moiety into well‐known DO3A platform imparts desired sensitivity corresponding Gd 3+ complex. The amine group accessible and easy functionalize; particular, possibility tuning its p K AH through N ‐substitution makes it good pH‐responsive functionality access novel class tailored pH‐sensitive...
Abstract N ‐Substituted aminoethyl groups were attached to 1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acid (DO3A) with the aim design pH‐responsive Ln III complexes based on pH‐dependent on/off ligation of amine nitrogen metal ion. The following ligands synthesized: AE ‐ DO3A (aminoethyl‐DO3A), MAE ( ‐methylaminoethyl‐DO3A), DMAE , ‐dimethylaminoethyl‐DO3A) and MEM ‐methoxyethyl‐ ‐methylaminoethyl‐DO3A). physicochemical properties investigated for evaluation their potential applicability...
Falcarindiol (1), a C-17 polyacetylenic diol, shows pleiotropic profile of bioactivity, but the mechanism(s) underlying its actions are largely unknown. Large amounts 1 co-occur in water hemlock (Oenanthe crocata) along with convulsant toxin oenanthotoxin (2), potent GABA(A) receptor (GABA(A)R) inhibitor. Since these compounds structurally and biogenetically related, it was considered interest to evaluate whether could affect GABAergic activity, for this purpose model hippocampal cultured...
Two structurally constrained chelators based on a fused bicyclic scaffold, 4-amino-4-methylperhydro-pyrido[1,2-a][1,4]diazepin-N,N',N'-triacetic acids [(4R*,10aS*)-PIDAZTA (L1) and (4R*,10aR*)-PIDAZTA (L2)], were designed for the preparation of GaIII -based radiopharmaceuticals. The stereochemistry ligand scaffold has deep impact properties complexes, with unexpected [Ga(L2)OH] species being superior in terms both thermodynamic stability inertness. This peculiar behavior was rationalized...
The structure, stability and magnetic properties of novel ditopic Mn(<sc>ii</sc>)-complexes were studied by molecular modeling, potentiometric relaxometric techniques.
Abstract Unprecedented fast and efficient complexation of Sc III was demonstrated with the chelating agent AAZTA (AAZTA=1,4‐bis(carboxymethyl)‐6‐[bis(carboxymethyl)]amino‐6‐methylperhydro‐1,4‐diazepine) under mild experimental conditions. The robustness 44 Sc(AAZTA) − chelate conjugated biomolecules thereof is further shown by in vivo PET imaging healthy tumor mice models. new results pave way towards development Sc‐based radiopharmaceuticals using chelator.
Abstract Magnetic resonance imaging (MRI) is a non‐invasive diagnostic modality routinely employed in modern clinical medicine to collect images of the internal organs human body. Contrast agents (CA) are usually administered patients improve sensitivity this technique and nowadays these gadolinium complexes. Bifunctional chelating (BFCAs) dual molecules containing multidentate ligand, able strongly coordinate metal ion, reactive moiety for conjugation purposes. With BFCAs an easy labelling...
Vanillin is widely used as a flavoring agent in foods, perfumes and several other applications. Even if huge amounts of vanillin are annually employed these manufacturing processes, its reactivity underexplored, especially for the formation potentially toxic substances. In this context, we observed orange to red crystalline compounds reaction with secondary amines aerobic conditions. NMR HRMS allowed identifying products 2,5‐diamino‐1,4‐benzoquinones. Preliminary investigations led proposed...
Prompted by the favourable relaxometric, thermodynamic and kinetic properties of bis-hydrated Gd(OBETA) (OBETA=2,2'-oxybis(ethylamine)-N,N,N',N'-tetraacetic acid) complex, a novel derivative tailored with an n-hexadecyl chain was synthesised. The amphiphilic gadolinium complex designed prepared aim obtaining high relaxivity supramolecular aggregates self-assembly in micelles liposomes. Thus, lipidic nanoparticles were characterised dynamic light scattering 1 H NMR relaxometry. Relaxivity...
Structurally related heptadentate (OBETA, EHDTA) and octadentate (EGTA) ligands form Mn 2+ complexes that exhibit distinct characteristics in terms of relaxivity, thermodynamic stability, and, most notably, kinetic inertness.