A5105003234- Balance, Gait, and Falls Prevention
- Ion Transport and Channel Regulation
- Magnesium in Health and Disease
- Neurological disorders and treatments
- Optical Imaging and Spectroscopy Techniques
- Gastrointestinal motility and disorders
- Alcoholism and Thiamine Deficiency
- Noise Effects and Management
- Mechanical Circulatory Support Devices
- Muscle activation and electromyography studies
- Urban Transport and Accessibility
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
- Clinical Nutrition and Gastroenterology
- Pain Management and Treatment
- Membrane-based Ion Separation Techniques
- Ion channel regulation and function
- Genomics and Rare Diseases
- Vitamin K Research Studies
- Spinal Cord Injury Research
- Clostridium difficile and Clostridium perfringens research
- Heart Rate Variability and Autonomic Control
- Vitamin C and Antioxidants Research
- Cerebral Palsy and Movement Disorders
- Transcranial Magnetic Stimulation Studies
Malcom Randall VA Medical Center
2022-2024
University of Florida
2017-2024
Florida College
2021
Howard Hughes Medical Institute
2015
Centre National de la Recherche Scientifique
2015
Sorbonne Université
2015
Inserm
2015
University of Washington
2015
To investigate the clinical spectrum and distinguishing features of adenylate cyclase 5 (ADCY5)-related dyskinesia genotype-phenotype relationship.We analyzed ADCY5 in patients with choreiform or dystonic movements by exome targeted sequencing. Suspected mosaicism was confirmed allele-specific amplification. We evaluated our 50 new previously reported cases.We identified 3 families 12 sporadic cases mutations. These mutations cause a mixed hyperkinetic disorder that includes dystonia,...
Introduction Walking in complex environments increases the cognitive demand of locomotor control; however, our understanding neural mechanisms contributing to walking on uneven terrain is limited. We used a novel method for altering unevenness treadmill investigate association between and cortical activity prefrontal cortex, region known be involved various functions. Methods Prefrontal was measured with functional near infrared spectroscopy while participants walked custom-made surface...
BACKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous system. Calcium-sensing receptor (CaSR) inhibits both actions. The latter has been well documented in vitro but not vivo . hypothesis to be tested was that CaSR AIM To determine whether agonists ameliorate secretory evoked cholera toxin (CTX) mice. METHODS CTX given orally C57BL/6 mice induce diarrhea. Calcium calcimimetic R568 were used activate CaSR. maximize their...
To identify potential risk factors for pre- and postoperative seizures epilepsy in children with congenital heart disease.Retrospective cohort study of neonates infants <3 months age disease who underwent cardiopulmonary bypass from November 24, 2006, until June 1, 2015. Children were classified based on time occurrence into early preoperative, postoperative, late postoperative. recurring 30 days after cardiac surgery met criteria epilepsy.247 patients completed follow-up; 2.4% had...
Introduction: Dual-task walking is common in daily life but becomes more difficult with aging. Little known about the neurobiological mechanisms affecting competing cognitive demands. Translational studies human and animal models are needed to address this gap. This pilot study investigated feasibility of implementing a novel cross-species dual-task model humans rats aimed establish preliminary evidence that induces cost. Methods: Young older performed an object discrimination task (OD),...
This study investigated locomotor learning of a complex terrain walking task in older adults, when combined with two adjuvant interventions: transcutaneous spinal direct current stimulation (tsDCS) to increase lumbar cord excitability, and textured shoe insoles somatosensory feedback the cord. The has crucial contribution control walking, is novel therapeutic target for rehabilitation adults. involved 10-meter course consisting nine obstacles three sections compliant (soft) surface....
Walking performance and cognitive function demonstrate strong associations in older adults, with both declining advancing age. requires the use of resources, particularly complex environments like stepping over obstacles. A commonly implemented approach for measuring control walking is a dual-task assessment, which combined second task. However, assessments have shortcomings, including issues scaling task difficulty controlling prioritization. Here we present new assessment designed to be...
Mammalian colonic epithelia consist of cells that are capable both absorbing and secreting Cl-. The present studies employing Ussing chamber technique identified two opposing short-circuit current (Isc) responses to basolateral bumetanide in rat distal colon. Apart from the transepithelial Cl--secretory Isc early colon was inhibited by bumetanide, also stimulated late had not previously been identified. Since inhibits Na+-K+-2Cl- cotransporter (NKCC) crypt K+-Cl- (KCC) surface epithelium, we...
Abstract Diarrhea like cholera remains a leading cause of mortality and morbidity globally. Oral rehydration solution (ORS) that developed in 1970s significantly decreases diarrhea mortality; yet, it does not reduce its usage has reduced persistently. Patients with lose only monovalent ions Na + , K Cl − HCO 3 which are replaced via ORS, but also divalent Zn 2+ Ca routinely replaced, particularly for . Using several vitro technologies performed isolated tissues, we have previously shown...
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