A5047477153- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Advanced biosensing and bioanalysis techniques
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- RNA Interference and Gene Delivery
- Cardiac Structural Anomalies and Repair
- DNA and Nucleic Acid Chemistry
- Cardiovascular Issues in Pregnancy
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Trauma Management and Diagnosis
- Family and Patient Care in Intensive Care Units
- RNA and protein synthesis mechanisms
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Vascular anomalies and interventions
- Cardiac Ischemia and Reperfusion
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
University of Florida
2016-2025
Florida College
2012-2025
University of Florida Health
2009-2024
University of Cincinnati Medical Center
2024
UF Health Shands Hospital
2016-2022
University of Oxford
2021
Prince Charles Hospital
2021
Faculty of 1000 (United States)
2021
RELX Group (United States)
2021
John Wiley & Sons (United Kingdom)
2018
An apt modification: A simple and effective way to modify the cell surface with target-specific ligands, such as DNA aptamers, while minimizing effects on modified cells has been developed. After incubating lipo–aptamer probes, immune (red, see scheme) recognize kill cancer (blue) in mixture. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or...
Abstract Purpose: High takeoff of the right coronary artery suspected by echocardiography is widely considered a normal variant. However, in our experience, some patients initially thought to have high were later found an anomalous origin with high-risk features. The aim this study was test hypothesis that may indicate presence lesion intramural course requiring further investigation. Methods: A retrospective chart review performed evaluated at University Florida Congenital Heart Center from...
Background Understanding the molecular features of specific tumors can increase our knowledge about mechanism(s) underlying disease development and progression. This is particularly significant for colorectal cancer, which a heterogeneous complex diseases developed in sequential manner through multistep carcinogenic process. As such, it likely that with similar characteristics might originate same have behavior. Therefore, mapping be potentially useful both tumor classification appropriate...
Background Ovarian cancer is the most lethal gynecological malignancy, and ovarian clear cell carcinoma subtype (OCCA) demonstrates a particularly poor response to standard treatment. Improvements in outcomes, especially for OCCA, could be expected from clearer understanding of molecular pathology that might guide strategies earlier diagnosis more effective Methodology/Principal Findings Cell-SELEX technology was employed develop new probes surface markers. A total thirteen aptamers with...
Echocardiography is the mainstay for diagnosing congenital heart disease (CHD). Diagnostic errors can lead to suboptimal surgical outcomes. This multicenter pediatric echocardiography collaborative learning initiative explores reasons diagnostic errors, investigates associations between patient- and center-specific factors relays benefits of a approach decrease these as first step improve CHD Participating centers submitted evaluations on patients prior 2-ventricle repair into central...
Abstract Introduction: Fear of cardiac arrest among parents infants with heart disease can cause stress and anxiety. Literature is scarce on the effects cardiopulmonary resuscitation training (CPRt) anxiety parents. We analysed impact CPRt anxiety, stress, comfort levels disease. Methods: Cardiopulmonary (CPR) choking relief manoeuvre (CRM) level, Parental State-Trait Anxiety Inventory (STAI), Parenting Stress Index (PSI) scores were prospectively collected pre-, immediately post-, 3 months...
The American Heart Association (AHA) advocates for CPR education as a requirement of secondary school curriculum. Unfortunately, many states have not adopted education. Our aim was to investigate low-cost, time effective method educate students on Basic Life Support (BLS), including reeducation. This is prospective, randomized study. Retention assessed at 4 months post-initial Education performed by AHA-certified providers during 45-minute physical class in middle Florida. age provides...
Gelungene Modifizierung: Zelloberflächen können auf einfache Weise mit zielspezifischen Liganden wie DNA-Aptameren versehen werden, wobei die Auswirkungen modifizierten Zellen minimal gehalten werden. Nach Inkubation Lipoaptamer-Sonden erkennen Immunzellen (rot, siehe Schema) in einer Zellmischung Krebszellen (blau) und zerstören diese. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be...
Lung cancer is the most lethal malignancy in world, and each year thousands of people die from this disease. Early detection has proven to increase 5-year survival for general, independent origination site lung. To address challenge, we have used cell-based SELEX (Systematic Evolution Ligands by Exponential Enrichment) select a panel aptamers capable distinguishing lung adenocarcinoma cells normal epithelial cells. These bind at physiological formalin-fixed conditions display affinity their...
Background: Nitric Oxide (NO) is a naturally occurring modulator of inflammation found in the human body. Several studies pediatric cardiothoracic surgery literature have demonstrated some beneficial clinical effects when NO added to sweep gas cardiopulmonary bypass circuit. Purpose: Our primary aim was determine safety incorporating nitric oxide into oxygenator extracorporeal membrane oxygenation (ECMO) Secondarily, we looked at important outcomes, such as survival, blood product...
We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release molecules at tumor surface using DNA template assisted functional group transfer reactions (DTGTR).
Isolated coarctation of the aorta can be repaired by either lateral thoracotomy or sternotomy approach with end-to-end anastomosis. Most commonly, neonates also have hypoplasia arch, requiring median and extended end-to-side anastomosis arch augmentation. The aim this study was to describe our experience as institution adopted for repair, reviewing complications, mortality, reintervention.Retrospective chart review 66 patients aged 0-1 year who had repair performed a single surgeon over an...
Planning corrective and palliative surgery for patients who have complex congenital heart disease often relies on the assessment of cardiac anatomy using two-dimensional noninvasive imaging modalities (echocardiography, magnetic resonance imaging, computed tomography scan). Advances in now include use three-dimensional (3D) reconstruction tools that produce 3D images printouts. There is scant evidence available literature as to what effect availability printouts defects has surgical...
To identify potential risk factors for pre- and postoperative seizures epilepsy in children with congenital heart disease.Retrospective cohort study of neonates infants <3 months age disease who underwent cardiopulmonary bypass from November 24, 2006, until June 1, 2015. Children were classified based on time occurrence into early preoperative, postoperative, late postoperative. recurring 30 days after cardiac surgery met criteria epilepsy.247 patients completed follow-up; 2.4% had...