A5023830456- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Peripheral Neuropathies and Disorders
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Respiratory and Cough-Related Research
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Ocular Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Ear Surgery and Otitis Media
Centre Hospitalier de Valence
2018-2024
Hospices Civils de Lyon
2012-2020
Hôpital de la Croix-Rousse
2012-2020
Université Claude Bernard Lyon 1
2012-2016
Office of Infectious Diseases
2016
Institute of Parasitology
2016
Inserm
2013-2015
Centre International de Recherche en Infectiologie
2013-2015
Centre National de la Recherche Scientifique
2013-2015
Hospital for Tropical Diseases
2015
Background Transverse myelitis is a rare complication of systemic lupus erythematosus (SLE). This retrospective multicentre study identifies the prognostic factors in relatively large patient series. Patients and methods Twenty patients fulfilled SLE criteria ACR classification Myelitis Consortium Working Group. A severe neurological flare was defined as muscle strength grade <3/5 more than half groups at motor level. Inability to run or another significant ambulation-unrelated disability...
Objective To evaluate the efficacy of covid-19 convalescent plasma to treat patients admitted hospital for moderate disease with or without underlying immunodeficiency (CORIPLASM trial). Design Open label, randomised clinical trial. Setting CORIMUNO-19 cohort (publicly supported platform open controlled trials immune modulatory drugs in severe disease) based on 19 university and general hospitals across France, from 16 April 2020 21 2021. Participants 120 adults (n=60 group, n=60 usual care...
Diagnosis of peritoneal tuberculosis (pTB) is difficult, even in developed countries, where data are lacking. The aim the present study was to describe clinical presentation, diagnosis, and bacterial epidemiology pTB France over a 10-year period.A retrospective conducted on two university hospitals France, between January 2004 December 2014.Among 34 patients, 76.5% were migrants from areas endemic (TB), mainly Africa. main presentation (85.3%) checkup ascites or suspicion carcinomatosis. On...
The mechanisms sustaining the absence of complete immune recovery in HIV-infected patients upon long-term effective highly active anti-retroviral therapy (HAART) remain elusive. Immune activation, regulatory T cells (T(regs)) or very low-level viraemia (VLLV) have been alternatively suspected, but rarely investigated simultaneously. We performed a cross-sectional study aviraemic subjects (mean duration HAART: 12 years) to concomitantly assess parameters associated independently with...
Abstract Background: Although likely pivotal, the role of regulatory T cells (Tregs) in HIV pathogenesis remains elusive. This can be partly explained by analytical issues regarding their phenotypic identification clinical studies. Instead intracellular FOXP3 staining, CD4+CD25+CD127− phenotype has been proposed as an alternative to identify Tregs samples. However, its use controversial viremic patients. Therefore, objective present study was assess correlation between frequencies and...
Summary Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report neutropenic patient who developed severe sino‐orbito‐cerebral H. infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high‐dose regimen antifungal drugs.
Background. Atypical mycobacteria, or nontuberculous mycobacteria (NTM), have been barely reported as infective endocarditis (IE) agents. Methods. From January 2010 to December 2013, cardiac valve samples sent our laboratory cases of blood culture-negative suspected IE were analyzed by 16S rDNA polymerase chain reaction (PCR). When positive for NTM, hsp PCR allowed species identification. Demographic, clinical, echocardiographic, histopathological, and Ziehl-Neelsen staining data then...
Abstract Background. The primary aim of this study was to determine the impact regulatory T cells (Tregs) percentage on immune recovery in human immunodeficiency virus (HIV)-infected patients after antiretroviral therapy introduction. Methods. A 2-year prospective conducted HIV-1 chronically infected naive with CD4 count &lt;500 cells/mm3. Regulatory were identified as CD4+CD25highCD127low among CD4+ lymphocytes. Effect Treg at inclusion evolution overtime analyzed using a mixed-effect...
Abstract Background: By measuring multiple parameters on a single‐cell basis, flow cytometry is potent tool to dissect the phenotypes and functions of cell subsets. However, because this technique may be time‐consuming, particularly for intracellular staining, it could problematic its use in daily routine or large cohorts. Recently, novel reagent has been developed perform staining one step. The objective our study was thus assess new method comparison with reference by focusing FOXP3...
Abstract Objectives Efficacy of convalescent plasma in COVID-19 pneumonia (CPP) is uncertain, especially immunocompromised patients. CORIMUNO-CORIPLASM an open-label, Bayesian randomised clinical trial embedded the CORIMUNO trials platform that evaluated efficacy CCP patients with moderate COVID-19. Setting 19 university and general hospitals across France. Participants Adult hospitalized a positive SARS-CoV2 test, duration symptoms < 9 days WHO score severity 4 or 5 who signed written...
Eye damage during invasive aspergillosis is rarely described and biological diagnosis remains challenging. Here we report the case of a heart transplant recipient with ocular complicating disseminated aspergillosis. Although voriconazole was rapidly given, decrease in visual acuity right eye consistent endophthalmitis, resulting an emergency vitrectomy. The confirmed: laboratory results showed presence Aspergillus fumigatus vitreous sample. A series systemic antifungal medications (liposomal...
Introduction The incomplete immune recovery upon effective long‐term highly active antiretroviral therapy (HAART) has been associated with increased morbidity and mortality in HIV infected patients [ 1 ]. Immune cellular activation, Tregs or very low‐level viraemia alternatively suspected, but never investigated simultaneously 2 Materials Methods We performed a cross‐sectional study 87 aviraemic (men=62, mean CD4+T cells=570/mm 3 , duration of HAART=12 years). Patients at least 500 CD4+ T...
Abstract This prospective study aimed to determine factors associated with detection of very low‐level viremia in patients infected HIV‐1 virological success following HAART introduction. Fifty‐seven patients, mostly (n = 51, 89%) treated a protease inhibitor‐based regimen, were included and followed for 2 years. Viral loads monitored by Abbott m2000 RealTime HIV‐1. Patients classified as (i) HIV‐RNA‐negative if viral remained strictly undetectable (0 copies/ml), or (ii) HIV‐RNA‐positive at...
Introduction The coronavirus Severe Acute Respiratory Syndrome Coronavirus Type 1 induces a severe respiratory disease, disease 2019 (COVID-19). After and Middle East infection, increased post-traumatic stress disorder (PTSD) rates were described. Methods This single-centred, prospective study aimed to evaluate the of PTSD in patients who hospitalized for COVID-19. Inclusion criteria COVID-19 intensive care unit (ICU) or standard with at least 2 L/min oxygen. Six months post-hospitalization,...
A 55 year-old man was admitted for worsening of a chronic low back pain associated with L4-L5 anterolisthesis, despite taking non-steroidal anti-inflammatory drugs several months. He had medical history high blood pressure and obesity (body mass index, 37 kg/m2). lived in the countryside but no direct contact animals except his dog. There were fever, chills, sweats or weight loss. C reactive protein (CRP) <2.9 mg/L. Radiographs showed anterolisthesis endplate erosions bony sclerosis (figure...
An HIV-infected patient presenting an unexpected viral escape under combined antiretroviral treatment is described. The virus isolated from plasma contained a large deletion in the HIV-1 integrase gene but no known resistance mutation. Nested polymerase chain reactions (PCRs) with integrase-specific primers and probes were developed used to detect mutant plasma, blood, rectal biopsies, sperm. variant progressively emerged during period of therapy-induced virosuppression, persisted at low...
The authors describe the case of fatal cumulative toxicities in a 58-year-old AIDS-free, HIV-infected patient, who successively developed under highly active antiretroviral therapy (HAART): severe lipodystrophy, complicated osteoporosis, non-cirrhotic portal hypertension liver (with ascites, thrombosis, oesophageal varices and protein-losing enteropathy) due to nodular regenerative hyperplasia. These HAART-related led death, despite symptomatic treatment switch antiretrovirals (especially...
A 72-year-old woman was referred to the infectious diseases department with febrile respiratory distress. Her medical history mainly featured stage II chronic obstructive pulmonary disease. She had a dry hacking cough for 2 weeks, attacks. There were no abnormalities on auscultation. presented biological inflammatory syndrome (C reactive protein 173 mg/L), hyponatraemia and moderately elevated liver enzymes. CT revealed bilateral interstitial infiltrates …
We report a case of severe Bartonella quintana endocarditis in 40-year-old woman, with history moderate aortic regurgitation. She was employed private school, and had good socioeconomic condition. reported arthralgia palpitation for few months, neither symptoms heart failure nor fever. A systematic transthoracic echocardiography performed, followed by transoesophageal echocardiography, which revealed regurgitation large vegetation (20 mm, figure 1A, B). There were splenic renal infarctions...