A5101476796- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Spinal Fractures and Fixation Techniques
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Esophageal and GI Pathology
- Urological Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Neurological Disease Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Phytoestrogen effects and research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Molecular Research
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Pediatric Urology and Nephrology Studies
- Innovative Educational Techniques
- Peroxisome Proliferator-Activated Receptors
Shanghai Pulmonary Hospital
2025
Tongji University
2025
Fudan University Shanghai Cancer Center
2022-2024
Shandong University
2012-2024
Cangzhou Central Hospital
2024
People's Hospital of Cangzhou
2024
Center for High Pressure Science & Technology Advanced Research
2022-2023
Shanghai Institute of Hematology
2023
Fosun Pharma (China)
2022
Third Affiliated Hospital of Guangzhou Medical University
2014
Abstract This study aimed to evaluate the efficacy and safety of induction immunochemotherapy followed by definitive chemoradiotherapy (CRT) for unresectable locally advanced non‐small cell lung cancer (LA‐NSCLC). We identified stage III NSCLC patients who received immunochemotherapy. Overall survival (OS) progression‐free (PFS) were primary endpoints. From February 2019 August 2022, 158 enrolled. Following completion immunochemotherapy, objective response rate (ORR) disease control (DCR)...
Abstract This prospective study explores the prognostic value of circulating tumor DNA (ctDNA) and positron emission tomography/computed tomograpy (PET/CT) in unresectable locally advanced non‐small cell lung cancer (LA‐NSCLC) treated with definitive chemoradiotherapy (CRT). The discovery set includes 62 patients, baseline 53 post‐CRT plasma samples. PET/CT is performed at baseline, 33 patients undergo mid‐treatment scans after 40 Gy. Baseline ctDNA detected 71.0% patients. Pre‐treatment...
In this study, the oxidative changes of flaxseed oil at different heating temperatures were investigated.The degradation was evaluated by monitoring peroxide value, fatty acid composition, content conjugated dienes as absorbance 232 nm, trienes 270 nm.Results showed that both time and temperature had significant influence on deterioration oil.The specific extinction coefficient nm increased with increasing each temperature.The relative percentage linolenic obviously decreased time.However,...
We investigated scoliosis incidence among junior high school students in Zhongshan city, Guangdong, China and the expression of miR-30e those with scoliosis.
Abstract HER2 has long been a target of high interest for antibody and drug conjugate (ADC) therapeutics due to its well-documented overexpression in breast, gastric lung cancer. While trastuzumab ado-trastuzumab emtansine (T-DM1) have become an integral part treatment paradigms HER2-positive cancer, the more recent approvals fam-trastuzumab deruxtecan (DS-8201) ADC Fc-engineered margetuximab highlighted potential continued improvement over existing HER2-targeting therapies. IKS014 is...
Radiotherapy is one of the main local treatment modalities for prostate cancer, while immunosuppressive effect induced by radiotherapy an important factor radiation resistance and failure. Carbon ion (CIRT) a novel technique immunomodulatory CIRT provides possibility overcoming radioresistance improving efficacy. The aim this study was to assess immune response evoked in localized cancer patients.Thirty-two patients were treated combined with or without hormone therapy peripheral blood...
A human cadaveric biomechanical study of a novel, prefabricated autogenous bone interbody fusion (ABIF) cage.To evaluate the properties ABIF cage in single-level construct with and without transpedicular screw rod fixation.In current practice, posterior lumbar is generally carried out using synthetic spacers or corticocancellous iliac crest graft (ICBG) combination instrumentation. However, questions remain concerning use intervertebral implants as well morbidity ICBG harvesting. Therefore,...
Abstract Background Due to the physical dose distribution characteristic of “Bragg peak” and biological effect as a kind high linear energy transfer ray, heavy ion therapy has advantages over conventional photon in both efficacy safety. Based on evidence that prostate cancer lesions before treatment are most common sites tumor residual or recurrence after treatment, simultaneous integrated boost radiation for been proven have advantage improving without increasing toxicities. Methods This...
Abstract Coronary heart disease is the world's leading cause of death. Vasculogenesis, sprouting angiogenesis, intussusceptive coalescent vessel co-option, vasculogenic mimicry and arteriogenesis are seven main ways collateral development. However, none methods development sufficient to timely rescue a large number dying myocardial cells in infarction area. In this study, we first proposed hypothesis that vascular smooth muscle cell (VSMC) solid cords precursors vessels confirmed existence...
Introduction We aimed to investigate the feasibility of metabolomics explain underlying biological implications radiomics features obtained from magnetic resonance imaging (MRI) preceding carbon ion radiotherapy (CIRT) in patients with prostate cancer and further explore clinical significance on prognosis patients, based their biochemical recurrence (BCR) status. Methods Metabolomic results using high-performance liquid chromatography coupled tandem mass spectrometry urine samples, combined...
As local recurrence remains a challenge and the advantages of simultaneous integrated boost (SIB) technique have been validated in photon radiotherapy, we applied SIB to CIRT. The aim was investigate metabolomic changes CIRT with concurrent androgen deprivation therapy (ADT) localized prostate cancer (PCa) unique metabolic effect technique.This study enrolled 24 pathologically confirmed PCa patients. All patients went through ADT. gross target volume (GTV) defined as positive lesions on both...
Objective To study the effects of spironolactone on TGF - β1, and CTGF glomeru-losclerosis rats. Methods Forty normal male Sprague Dawley rats were randomly divided into following four groups after one week adaptive breeding: group A (spironolactone group), B +losartan potassium C (model D (sham operation group). Glomerulosclerosis model induce by unilateral nephrectomy injecting via vein adriamyci observed glomerulosclerosis Results Proteinuria in significantly lower than that either at 4th...