A5103280453- Housing Market and Economics
- Crime, Illicit Activities, and Governance
- Banking stability, regulation, efficiency
- Academic and Historical Perspectives in Psychology
- Housing, Finance, and Neoliberalism
- Glycosylation and Glycoproteins Research
- Terrorism, Counterterrorism, and Political Violence
- Global Financial Crisis and Policies
- Financial Literacy, Pension, Retirement Analysis
- Monetary Policy and Economic Impact
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Adolescent Sexual and Reproductive Health
- Insurance and Financial Risk Management
- State Capitalism and Financial Governance
- Cellular transport and secretion
- Carbohydrate Chemistry and Synthesis
- HIV, Drug Use, Sexual Risk
- Free Will and Agency
- Crime Patterns and Interventions
- Lysosomal Storage Disorders Research
- Media Studies and Communication
- Distributed systems and fault tolerance
- Crime, Deviance, and Social Control
- Sex work and related issues
Children's Hospital of Orange County
2025
Bakersfield College
2022
Central Bank of Ireland
2011-2021
State University of New York
2020
HCA Healthcare
2019
University at Buffalo, State University of New York
1982-2019
University of Michigan
1995-2018
Trinity College Dublin
2018
National University of Ireland, Maynooth
2013-2018
New Mexico Institute of Mining and Technology
2018
Synthesis of soluble A, B, H, and Lewis b blood group antigens in humans is determined by the Secretor (Se) (FUT2) locus. Genetic, biochemical, molecular analyses indicate that this locus corresponds to an α(1,2)fucosyltransferase gene distinct from genetically-linked H The accompanying paper (Rouquier, S., Lowe, J. B., Kelly, R. J., Fertitta, A. L., Lennon, G. G., Giorgi, D.(1995) Biol. Chem. 270, 4632-4639) describes cloning mapping two human DNA segments are physically linked to,...
We and others have previously described the isolation of three human alpha (1,3)fucosyltransferase genes which form basis a nascent glycosyltransferase gene family. now report molecular cloning expression fourth homologous gene. When transfected into mammalian cells, this fucosyltransferase is capable directing Lewis x (Gal beta 1-->4[Fuc 1-->3]GlcNAc), sialyl (NeuNAc 2-->3Gal 1-->4 [Fuc difucosyl 1-->3]GlcNAc 1-->3 Gal 1-->3]GlcNAc) epitopes. The enzyme shares 85% amino acid sequence...
We have used the human Lewis blood group fucosyltransferase cDNA and cross-hybridization procedures to isolate a gene that encodes distinct fucosyltransferase. Its DNA sequence predicts type II transmembrane protein whose is identical 133 of 231 amino acids at corresponding positions within catalytic domain When expressed by transfection in cultured cell lines, this determines expression capable efficiently utilizing N-acetyllactosamine form x determinant (Gal beta 1—-4[Fuc alpha...
To assess whether differences in age between sexual partners affect the risk of HIV infection female adolescents and young adults.A total 6177 ever sexually active women aged 15 to 29 years completed a sociodemographic behavior questionnaire provided blood sample for HIV-1 serology. The difference was categorized as men 0 4 older (referent group), 5 9 10 or more older. prevalence incidence were assessed, adjusted RR estimated by multivariate regression.Prevalent participants increased with...
Background Male circumcision is associated with reduced HIV acquisition. Methods acquisition was determined in a cohort of 5507 HIV-negative Ugandan men, and 187 men discordant relationships. Transmission 223 HIV-positive partners. incidence per 100 person years (py) adjusted rate ratios (RR) 95% confidence intervals (CI) were estimated by Poisson regression. HIV-1 serum viral load for the seropositive partners HIV-discordant couples. Results The prevalence 16.5% all men; 99.1% Muslims 3.7%...
Objective: To describe the design and first-round survey results of a trial intensive sexually transmitted disease (STD) control to reduce HIV-1 incidence. Study design: Randomized, controlled, community-based in Rakai District, Uganda. Methods: In this ongoing study, 56 communities were grouped into 10 clusters designed encompass social/sexual networks; within blocks randomly assigned intervention or arm. Every months, all consenting resident adults aged 15–59 years are visited home for...
We have used the human H blood group α(1,2)fucosyltransferase (FUT1) cDNA to screen chromosome 19 cosmid libraries in a search for Secretor (Se) gene (FUT2). One has been isolated that contains two distinct segments cross-hybridize with FUT1. assembled 100-kilobase (kb) contig, localized 19q13.3, encompassing FUT1 and FUT1-related sequences, termed Sec1 Sec2, candidate 1 2. Sec2 are separated by 12 kb 65.5 35 apart, respectively, from gene. cosmid-dependent direct selection method clone...
Lymphocyte homing to lymph nodes and Peyer's patches is mediated, in part, by adhesive interactions between L-selectin expressed lymphocytes ligands displayed at the surface of cuboidal endothelial cells lining post-capillary venules within lymphoid aggregates. Candidate terminal oligosaccharide structures thought be essential for effective ligand activity include a sulfated derivative sialyl Lewis × tetrasaccharide. Cell type-specific synthesis this presumed require one or more...
Le",)GlcNAc; Le", Galpl-,4(Fucal-3)GlcNAc; a(l,3/1,4)-fucosyltransferase, GDP-fu-Fucal-2Galpl-3GlcNAc; H type 2,
Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism reverse cholesterol transport, respectively. Whereas LPLA2 is predicted underlie the development drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease familial deficiency. Here we describe several high-resolution crystal structures human low-resolution structure...
Terminal Fucα1-3GlcNAc moieties are displayed by mammalian cell surface glycoconjugates in a tissue-specific manner. These oligosaccharides participate selectin-dependent leukocyte adhesion and have been implicated adhesive events during murine embryogenesis. Other functions for these molecules remain to be defined, as do the expression patterns of corresponding α-(1-3)-fucosyltransferase (α1-3FT) genes. This report characterizes α1-3FT that shares 77% amino acid sequence identity with human...
Objective: To assess whether circumcision performed on postpubertal men affords the same level of protection from HIV-1 acquisition as circumcisions earlier in childhood. Design: Cross-sectional study a population-based cohort. Setting: Rakai district, rural Uganda. Methods: A total 6821 aged 15-59 years were surveyed and venous blood samples tested for syphilis. Age at was dichotomized into who circumcised before or age 12 (prepubertal) after (postpubertal). Postpubertal also subdivided...
Five different human α(1,3)-fucosyltransferase (α(1,3)-Fuc-T) genes have been cloned. Their corresponding enzymes catalyze the formation of various α(1,3)- and α(1,4)-fucosylated cell surface oligosaccharides, including several that mediate leukocyte-endothelial adhesion during inflammation. Inhibitors such are predicted to operate as anti-inflammatory agents; in principle, isolation or design agents may be facilitated by identifying peptide segment(s) within these interact with their...
Abstract While most humans express an alpha(1,3)-fucosyltransferase in plasma, 9% of individuals on the isle Java (Indonesia) do not this enzyme. Ninety-five percent these plasma alpha(1,3)-fucosyltransferase-deficient have Lewis negative phenotype red cells, suggesting strong linkage disequilibrium between two traits. To define molecular basis for deficiency and to determine which candidate human genes encode enzyme (FUT5 FUT6), we cloned analyzed alleles at loci from Indonesian individual...
Five of the seven cloned human fucosyltransferase genes have been mapped to two clusters, one on 19q and other 19p. Comparative DNA sequence analysis showed Généthon microsatellite D19S596 lies 2.2 kb downstream coding region FUT1 indicating that cluster comprising closely linked FUT2 is located 4 cM distal D19S412 (lod score 13.7) 9 proximal D19S571 11.7). Polymorphic markers FUT3, FUT5 FUT6 were used for linkage with 14 microsatellites in Indonesian families. These three loci constitute a...
Three groups of children - those with divorced parents, from intact but rejected families, and accepted families were evaluated for self-esteem levels on the Piers-Harris Children's Self-Concept Scale. Contrary to current clinical impressions, parents not found evidence lower than intact-accepted families. Children intact-rejected however, evidenced significantly two other groups.