A5032948335- Adipose Tissue and Metabolism
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Folate and B Vitamins Research
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Gene expression and cancer classification
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Wound Healing and Treatments
- Metabolism, Diabetes, and Cancer
- Head and Neck Cancer Studies
- NF-κB Signaling Pathways
- Laser Applications in Dentistry and Medicine
- RNA modifications and cancer
- Cerebrospinal fluid and hydrocephalus
- Fibroblast Growth Factor Research
- Dermatologic Treatments and Research
- Metabolomics and Mass Spectrometry Studies
- Neuroblastoma Research and Treatments
- Multiple Myeloma Research and Treatments
Duke University
2025
University of California, Irvine
2023-2024
University of Michigan
2018-2022
Faculdade de Medicina de São José do Rio Preto
2016-2021
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker development. Recently, studies have shown secreted proteins mediating inter-tissue signaling could be identified by 'brute force' surveys of all genes within RNA-sequencing...
Patients presenting to the emergency department (ED) with chest pain often have abnormal high-sensitivity troponin (hsTn). However, only about 5% an acute coronary syndrome. We aimed assess safety, feasibility and utility of a clinical disposition protocol including outpatient observation stress cardiac-magnetic-resonance (CMR) in intermediate-risk patients hsTn unclear etiology. modified HEART-score≤6 underwent CMR inform diagnosis, risk-stratification, ED-disposition. were followed at 30...
Introdução: O manejo cirúrgico do Trauma Cranioencefálico Grave em crianças envolve abordagens específicas para minimizar danos e promover a recuperação. A avaliação inicial é crucial deve incluir realização de exames imagem determinar gravidade o tipo lesão. As intervenções cirúrgicas geralmente visam descompressão craniana, remoção hematomas ou correção fraturas. escolha procedimento depende da apresentação clínica condição neurológica criança. acompanhamento pós-operatório essencial...
The circadian rhythm regulates the physiology and behavior of living organisms in a time-dependent manner. Clock genes have distinct roles including control over gene expression mediated by transcriptional activators CLOCK BMAL1, suppression repressors PER1/2 CRY1/2. balance between repression is key to maintenance tissue homeostasis that disrupted event an injury. In skin, compromised epithelial barrier triggers cascade events culminate mobilization cells stem cells. Recruited migrate...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide characterized by a fast‐paced growth. Like other solid tumors, HNSCC growth rate results in development of hypoxic regions identified expression hypoxia‐inducible factor 1α (HIF‐1α). Interestingly, clinical data have shown that pharmacological induction intratumoral hypoxia caused an unexpected rise tumor metastasis accumulation cancer stem cells (CSCs). However, little known on molecular circuitries...
Folate metabolism is essential for DNA synthesis and repair.Alterations in genes that participate folate can be associated with several types of malignant neoplasms, including thyroid breast cancer.In the present case-control study, we examined association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) methionine synthase (MTR A2756G, rs1805087) polymorphisms risk cancer.Polymerase chain reaction-restriction fragment length technique was used to determine ©FUNPEC-RP...
Abstract Background The skin is the largest organ of human body. Upon injury, triggers a sequence signaling pathways that induce epithelial proliferation, migration, and ultimately, re-establishment barrier. Our study explores unknown epigenetic regulations wound healing from histone perspective. Posttranslational modifications histones enhance chromatin accessibility modify gene transcription. Methods Full-thickness wounds were made in dorsal twenty-four C57/B6 mice (C57BL/6J), followed by...
Abstract Introduction Alterations of the epigenome may influence cancer initiation and progression. At cellular level, histones are key regulators chromatin accessibility gene transcription; thus, inhibition histone deacetylase enzymes (HDACs) constitutes an attractive target for therapy. In this study, we investigated effects HDAC inhibitor entinostat on oral squamous cell carcinoma (OSCC). Materials Methods We tested OSCC lines. Cell viability growth were analyzed using MTT assay. cycle...
The human body is endowed with an extraordinary ability to maintain different oxygen levels in various tissues and organs. maintenance of physiological known as physoxia. development hypoxic conditions plays important role the biology several pathologies, including cancer. In vitro studies using normal neoplastic cells require that culture be carried out under appropriate levels, either physoxic or conditions. Such requirements are difficult widely implement laboratory practice, mainly due...
Asparaginase is fundamental to the treatment of haematological malignancies. However, little has been studied on effects that asparaginase could exert solid tumours. Thus, this study aimed evaluate an oral carcinoma cell line. The cytotoxicity in SCC-9 (tongue squamous carcinoma) and HaCaT (human keratinocyte) lines was evaluated with MTT viability assay. cells were treated at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, 5.0 IU/mL. Dose-response curves IC50 values obtained Tumour Selectivity Index (TSI)...
We investigated the association between methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthetase (MTR A2756G), synthase (MTRR A66G) polymorphisms involved in folate pathway breast cancer risk, interaction these tobacco alcohol consumption. Furthermore, we evaluated clinicopathological variables. This case-control study included 606 Brazilian women, comprising 128 patients with 478 controls. MTHFR MTR were genotyped using polymerase chain reaction-restriction...
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker development. Recently, studies have shown secreted proteins mediating inter-tissue signaling could be identified by ‘brute force’ surveys of all genes within RNA-sequencing...
Abstract Disclosure: M. Zhou: None. I. Tamburini: C. Van: J. Molendijk: L.M. Velez: Nguyen: R. Yeo: Filho: A.L. Hevener: Justice: Sparks: E.E. Kershaw: D. Nicholas: Seldin: Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker...
Abstract Disclosure: M. Zhou: None. I. Tamburini: C. Van: J. Molendijk: L.M. Velez: Nguyen: R. Yeo: Filho: A.L. Hevener: Justice: Sparks: E.E. Kershaw: D. Nicholas: Seldin: Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker...
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Beginning with the discovery of insulin over century ago, characterization molecules responsible for signal between tissues has required careful elegant experimentation where these observations have been integral deciphering physiology disease. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they...
Abstract/Introduction Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Beginning with the discovery of insulin over century ago, characterization molecules responsible for signal between tissues has required careful elegant experimentation where these observations have been integral deciphering physiology disease. Given that circulating bioactive factors are stable in serum, occur naturally, easily...