A5070122821- Adipose Tissue and Metabolism
- Bioinformatics and Genomic Networks
- Exercise and Physiological Responses
- Nutrition, Genetics, and Disease
- Muscle Physiology and Disorders
- Gene expression and cancer classification
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Muscle metabolism and nutrition
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
- Rheumatoid Arthritis Research and Therapies
- Spaceflight effects on biology
University of California, Irvine
2021-2024
National Institutes of Health
2022
University of California, San Francisco
2017
The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of lack specialized animal models, it unclear how tissue clocks interact with extrinsic signals to drive molecular oscillations. Here, we isolated interaction between feeding liver clock by reconstituting Bmal1 exclusively hepatocytes (Liver-RE), otherwise clock-less mice, controlling timing...
Skeletal muscle plays an integral role in coordinating physiological homeostasis, where signaling to other tissues via myokines allows for coordination of complex processes. Here, we aimed leverage natural genetic correlation structure gene expression both within and across understand how interacts with metabolic tissues. Specifically, performed a survey correlations focused on myokine regulation, cell composition, cross-tissue signaling, interactions sex humans. While levels majority...
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker development. Recently, studies have shown secreted proteins mediating inter-tissue signaling could be identified by 'brute force' surveys of all genes within RNA-sequencing...
To compare (sustained) DMARD-free remission rates((S)DFR), defined as respectively ≥6 months and >1 year, after 2 5 years between three clinical arthritis phenotypes; undifferentiated arthritis(UA), autoantibody-negative(RA-) positive rheumatoid arthritis(RA+).
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker development. Recently, studies have shown secreted proteins mediating inter-tissue signaling could be identified by ‘brute force’ surveys of all genes within RNA-sequencing...
Abstract Disclosure: M. Zhou: None. I. Tamburini: C. Van: J. Molendijk: L.M. Velez: Nguyen: R. Yeo: Filho: A.L. Hevener: Justice: Sparks: E.E. Kershaw: D. Nicholas: Seldin: Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker...
Abstract Disclosure: M. Zhou: None. I. Tamburini: C. Van: J. Molendijk: L.M. Velez: Nguyen: R. Yeo: Filho: A.L. Hevener: Justice: Sparks: E.E. Kershaw: D. Nicholas: Seldin: Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they present obvious focal molecules for therapeutic intervention biomarker...
Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that heterogeneity derives part from distinct stem cell populations co-exist as admixtures of varying proportions. However, the lack single resolution has prohibited a definitive identification these types cells and therefore any understanding how each influence phenotypes. Here were report isolation characterization two SW480 CRC line. We find are oncogenic versions...
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Beginning with the discovery of insulin over century ago, characterization molecules responsible for signal between tissues has required careful elegant experimentation where these observations have been integral deciphering physiology disease. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they...
Abstract/Introduction Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Beginning with the discovery of insulin over century ago, characterization molecules responsible for signal between tissues has required careful elegant experimentation where these observations have been integral deciphering physiology disease. Given that circulating bioactive factors are stable in serum, occur naturally, easily...
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes many human diseases. Beginning with the discovery of insulin over century ago, characterization molecules responsible for signal between tissues has required careful elegant experimentation where these observations have been integral deciphering physiology disease. Given that circulating bioactive factors are stable in serum, occur naturally, easily assayed from blood, they...
Group 3 medulloblastoma is a malignant childhood brain tumor with the worst prognosis among all subtypes of medulloblastoma. This subgroup has highest frequency MYC amplification. BRD4 member human bromodomain and extraterminal domain (BET) family proteins functions through binding acetylated lysines on histones, regulating expression oncogenes including MYC. BET inhibitors (BETi) are class epigenetic drugs that have been shown to inhibit hematologic solid malignancies, several BETi...
Abstract/Introduction Proteins secreted from skeletal muscle, termed myokines, allow muscle to impact systemic physiology and disease. Myokines play critical roles in a variety of processes, including metabolic homeostasis, exercise improvements, inflammation, cancer cognitive functions 1–6 . Despite the clear relevance these factors mediating multitude physiological outcomes, genetic architecture, regulation as well degree conservation communication circuits remains inadequately understood....