A5081025684- Alzheimer's disease research and treatments
- Antioxidant Activity and Oxidative Stress
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Dementia and Cognitive Impairment Research
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Fatty Acid Research and Health
- Bipolar Disorder and Treatment
- Medicinal Plants and Neuroprotection
- Problem and Project Based Learning
- Vitamin C and Antioxidants Research
- Suicide and Self-Harm Studies
- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Eating Disorders and Behaviors
National University of Malaysia
2016-2025
University Kebangsaan Malaysia Medical Centre
2011-2022
Macquarie University
2009-2021
Impairments in cognitive and locomotor functions usually occur with advanced age, as do changes brain volume. This study was conducted to assess volume, functions, oxidative stress levels middle- late-aged rats. Forty-four male Sprague-Dawley rats were divided into four groups: 14, 18, 23, 27 months of age. 1H magnetic resonance imaging (MRI) performed using a 7.0-Tesla MR scanner system. The volumes the lateral ventricles, medial prefrontal cortex (mPFC), hippocampus, striatum, cerebellum,...
Abstract Vitamin E acts as an antioxidant and reduces the level of reactive oxygen species (ROS) in Alzheimer’s disease (AD). Alpha-tocopherol (ATF) is most widely studied form vitamin besides gamma-tocopherol (GTF) which also shows beneficial effects AD. The levels amyloid-beta (Aβ) amyloid precursor protein (APP) increased brains AD patients, mutations APP gene are known to enhance production Aβ. Mitochondrial function was shown be affected by Aβ may induce cell death. Here, we aimed...
Alzheimer's disease (AD) is the most common cause of dementia. The cardinal neuropathological characteristic AD accumulation amyloid-β (Aβ) into extracellular plaques that ultimately disrupt neuronal function and lead to neurodegeneration. One possible therapeutic strategy therefore prevent Aβ aggregation. Previous studies have suggested vitamin E analogs slow progression in humans. In present study, we investigated effects tocotrienol-rich fraction (TRF), a mixture from palm oil, on amyloid...
Stress activates selected neuronal systems in the brain and this leads to activation of a range effector systems. Our aim was investigate some relationships between these under basal conditions over 40-min period response footshock stress. Specifically, we investigated catecholaminergic neurons locus coeruleus (LC), ventral tegmental area medial prefrontal cortex (mPFC) brain, by measuring tyrosine hydroxylase (TH) protein, TH phosphorylation activation. We also measured responses plasma...
The expression of c-Fos defines brain regions activated by the stressors hypotension and glucoprivation however, whether this identifies all sites involved is unknown. Furthermore, neurochemicals that delineate these regions, or are utilized in them when responding to remain undefined. Conscious rats were subjected hypotension, vehicle for 30, 60 120 min changes phosphorylation serine residues 19, 31 40 biosynthetic enzyme, tyrosine hydroxylase (TH), activity TH and/or, determined, up ten...
We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture vitamin E analogs, improves amyloid pathology in vitro and vivo. However, precise mechanisms remain unknown. In this study, we examined effects long-term (10 months) TRF treatment on behavioral impairments brain metabolites (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer’s disease (AD) mice. The open field test, Morris water maze, novel object recognition tasks revealed improved exploratory...
Decrease in multiple functions occurs the brain with aging, all of which can contribute to age-related cognitive and locomotor impairments. Brain atrophy specifically hippocampus, medial prefrontal cortex (mPFC), striatum, this age-associated decline function. Our recent metabolomics analysis showed changes these regions. To further understand aging processes, using a proteomics approach was carried out. This study conducted identify proteome profiles mPFC, striatum 14-, 18-, 23-,...
Background: Natural disasters may physically and psychologically affect individuals their surrounding community. This study determines the prevalence of post-traumatic stress (PTS) symptoms its association with maladaptive trauma-related cognition resilience among adolescents post-earthquake. Materials Methods: Data were collected, in this cross-sectional study, during an intervention program post-earthquake held a state high school located at Lombok, Indonesia. The sample engaged students...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive abilities. AD associated with aggregation amyloid-β (Aβ) deposited in the hippocampal brain region. Our previous work has shown that tocotrienol rich fraction (TRF) supplementation was able to attenuate blood oxidative status, improve behavior, reduce fibrillary-type Aβ deposition hippocampus an mouse model. In present study, we investigate effect 6 months TRF on...
The amyloid precursor protein (APP) processing pathway was altered in Alzheimer's disease (AD) and contributed to abnormal amyloid-beta (Aβ) production, which forms insoluble interneuron aggregates known as plaques the brain. Targeting APP is still fundamental for AD modifying therapy. Extensive research has evaluated protective effects of vitamin E an antioxidant a signaling molecule. present study aimed investigate modulatory different tocopherol isomers on expression genes involved...
Aging is a complex process characterized by progressive loss of functional abilities due to the accumulation molecular damages. Metabolomics could offer novel insights into predictors and mechanisms aging. This cross-sectional study aimed at identifying age-associated plasma metabolome in Malay population. A total 146 (90 females) healthy participants aged 28–69 were selected for study. Untargeted metabolomics profiling was performed using liquid chromatography-tandem mass spectrometry....
We have recently shown that age-dependent regional brain atrophy and lateral ventricle expansion may be linked with impaired cognitive locomotor functions. However, metabolic profile transformation in different regions during aging is unknown. This study examined changes the hippocampus, medial prefrontal cortex (mPFC) striatum of middle- late-aged Sprague-Dawley rats using ultrahigh performance liquid chromatography coupled high-resolution accurate mass-orbitrap tandem mass spectrometry....
Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine effects of age vitamin E supplementation form tocotrienol‐rich fraction (TRF) on brain metabolism. Male Wistar rats at ages 3 21 months were supplemented with TRF orally for prior dissection tissue from five regions. The concentrations L‐arginine its nine downstream metabolites quantified using high‐performance liquid chromatography tandem...
Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously demonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect brain. Proteomic analyses were performed on samples hippocampus, medial prefrontal cortex (mPFC), striatum using liquid chromatography coupled Q Exactive HF Orbitrap mass...
The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the transition, including cognitive deficits. Although studies in rodent models of menopause revealed learning memory, little known about structural regions serving function these models. administration 4-vinylcyclohexene diepoxide (VCD) laboratory animals results follicular depletion, thus, powerful...