A5028343495- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Cancer Mechanisms and Therapy
- Cardiovascular Issues in Pregnancy
- Hepatitis B Virus Studies
- Multiple Myeloma Research and Treatments
- Congenital heart defects research
- Hepatitis C virus research
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- TGF-β signaling in diseases
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- Calcium signaling and nucleotide metabolism
- Liver Disease and Transplantation
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Bone Metabolism and Diseases
- Drug-Induced Hepatotoxicity and Protection
Northwest University
2024
Temple University
2016-2023
Guangzhou Institutes of Biomedicine and Health
2016-2023
State Key Laboratory of Respiratory Disease
2016-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
Northwest University
2023
Geisinger Lewistown Hospital
2020-2022
Philadelphia University
2021-2022
National Institute of Diabetes and Digestive and Kidney Diseases
2022
ProQuest (United States)
2022
Lysosomal acid lipase is an essential lipid-metabolizing enzyme that breaks down endocytosed lipid particles and regulates metabolism. We conducted a phase 3 trial of enzyme-replacement therapy in children adults with lysosomal deficiency, underappreciated cause cirrhosis severe dyslipidemia.
Efavirenz is a commonly used antiretroviral drug that causes neurologic side effects in more than 50% of patients.To characterize efavirenz-associated symptoms randomized, controlled study initial treatment.Substudy double-blind, trial combination regimens (A5095) was performed between March 2001 and January 2002.Multicenter academic clinical units.HIV-infected patients who were initiating therapy the context trial.Neuropsychological performance measures, including Digit Symbol Substitution...
The effects of ACE-011 on safety, pharmacokinetics, and bone biomarkers were evaluated in healthy, postmenopausal women. Our data indicate that results a sustained increase formation reduction markers resorption. activin type IIA receptor (ActRIIA) is the high-affinity for activin. dimeric fusion protein consisting extracellular domain human ActRIIA linked to Fc portion IgG1. binds activin, preventing from binding endogenous receptors. A randomized, double-blind, placebo-controlled study was...
Introduction ACE‐031 is a soluble form of activin receptor type IIB (ActRIIB). promotes muscle growth by binding to myostatin and other negative regulators mass. Methods This double‐blind, placebo‐controlled study evaluated the safety, pharmacokinetics, pharmacodynamics in 48 healthy, postmenopausal women randomized receive 1 dose (0.02–3 mg/kg SC) or placebo (3:1). Results was generally well‐tolerated. Adverse events included injection site erythema. Mean AUC 0–∞ C max increased linearly...
Hemophagocytic lymphohistiocytosis (HLH) is a relatively rare but life-threatening disease with confusing clinical manifestations, rapidly deteriorating health, high morbidity and mortality.To improve the recognition as well understanding of this disorder, we analyzed characteristics prognostic factors from 85 adult patients diagnosed HLH in our hospital April 2005 to June 2014.Patients displayed variable markers across wide spectrum. These included fever hyperferritinemia (100%), elevated...
Embryonic heart is characterized of rapidly dividing cardiomyocytes required to build a working myocardium. Cardiomyocytes retain some proliferative capacity in the neonates but lose it adulthood. Consequently, number signaling hubs including microRNAs are altered during cardiac development that adversely impacts regenerative potential tissue. stem cell cycle miRs class exclusively expressed developmental stages; however, their effect on cardiomyocyte proliferation and function adult...
Objectives: The impact of highly active antiretroviral therapy (HAART) on hepatitis C virus (HCV) is unknown. We analysed changes in HCV RNA and the frequency hepatotoxicity co-infected patient enrolling AIDS Clinical Trials Group trials, determined whether impairs successful immune reconstitution these populations. Design/methods: In a prospective analysis patients completing at least 16 weeks HAART four with available stored plasma from two other completed was measured baseline to week 48....
Background: Efavirenz (EFV) is an antiretroviral (ARV) drug associated with neuropsychological effects. Limited data describing the long-term impact of EFV-based regimens on performance over more than 3 years are available. Methods: We enrolled a subset participants from large initially EFV placebo-controlled trial therapies for HIV subjects naïve to ARV treatment (A5095). Clinical follow-up continued 184 weeks study. Subjects were assessed brief testing, symptom questionnaire EFV-associated...
Ligands of the transforming growth factor-beta superfamily and activin-receptor signaling play an important role in erythropoiesis. Sotatercept, activin receptor type IIA (ActRIIA) ligand trap, is a novel, recombinant, fusion protein comprising extracellular domain human ActRIIA linked to Fc portion immunoglobulin G1. originally developed increase bone mineral density, was noted have robust effects on Here, we evaluated safety, pharmacokinetic properties, pharmacodynamic sotatercept 31...
Targeting p53 by the small-molecule PRIMA-1(Met)/APR-246 has shown promising preclinical activity in various cancer types. However, mechanism of PRIMA-1(Met)-induced apoptosis is not completely understood and its effect on multiple myeloma cells unknown. In this study, we evaluated antitumor PRIMA-1(Met) alone or combination with current antimyeloma agents cell lines, patient samples, a mouse xenograft model. Results our study showed that decreased viability irrespective status, limited...
Rationale: Ca 2+ -induced release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) junctional sarcoplasmic reticulum. CICR is disrupted cardiac hypertrophy heart failure, which associated with loss T-tubules disruption dyads. In these conditions, LTCCs are redistributed from to disrupt CICR. The molecular mechanism responsible for recruitment not well known. JPH (junctophilin) 2...
There is a paucity of information on the safety and efficacy lipid-lowering therapy for dyslipidemia associated with human immunodeficiency virus (HIV) antiretroviral therapy. Our objective was to determine whether fenofibrate pravastatin were equivalent treatment combined in HIV as measured by composite National Cholesterol Education Project (NCEP) goals based absolute values low-density lipoprotein (LDL), triglycerides (TG), high-density (HDL) compare these agents through 48 weeks. This...
Abstract Purpose: The angiogenesis inhibitor dalantercept (formerly ACE-041) is a soluble form of activin receptor–like kinase-1 (ALK1) that prevents activation endogenous ALK1 by bone morphogenetic protein-9 (BMP9) and BMP10 exhibits antitumor activity in preclinical models. This first-in-human study evaluated its safety, tolerability, pharmacokinetics, pharmacodynamics, adults with advanced solid tumors. Experimental Design: Patients dose-escalating cohorts received subcutaneously at one...
Rationale: Possible beneficial effects of GDF11 (growth differentiation factor 11) on the normal, diseased, and aging heart have been reported, including reversing aging-induced hypertrophy. These not well validated. High levels also shown to cause cardiac skeletal muscle wasting. controversies could be resolved if dose-dependent were defined in normal aged animals as pressure overload-induced pathological Objective: To determine hearts those with Methods Results: Twelve- 13-week-old C57BL/6...
Heart failure (HF) with preserved ejection fraction (HFpEF) is defined as HF an (EF) ≥ 50% and elevated cardiac diastolic filling pressures. The underlying causes of HFpEF are multifactorial not well-defined. A transgenic mouse low levels cardiomyocyte (CM)-specific inducible Cavβ2a expression (β2a-Tg mice) showed increased cytosolic CM Ca
A recent study suggests that systemic hypoxemia in adult male mice can induce cardiac myocytes to proliferate. The goal of the present experiments was confirm these results, provide new insights on mechanisms cardiomyocyte cell cycle reentry, and determine if also induces proliferation female mice.
Objective: To evaluate the effect of hepatitis C virus (HCV)/HIV co-infection on neuropsychological performance and neurological status in HIV/HCV treatment-naive HIV-1-infected individuals we conducted a cross-sectional study using baseline data from an HIV therapy trial. Methods: HCV was determined by presence anti-HCV antibodies. Neuropsychological function evaluated Trailmaking tests, Digit Symbol Task. Depression assessed Center for Epidemiologic Studies – Scale. Sleep quality...
To evaluate the effects of ketoconazole, rifampicin and efavirenz on pharmacokinetics telaprevir in healthy volunteers.
A highly efficient CRISPR/Cas9-based marker-free genome editing system has been established in Plasmodium falciparum (Pf). However, with the current methods, two drug-selectable markers are needed for episome retention, which may present hurdles consecutive manipulations due to limited number of available selectable markers. The loading capacity donor DNA is also unsatisfactory large size Cas9 nuclease and sgRNA co-expression system, limits knock-in fragments. Because inefficient end joining...
// Manujendra N. Saha 1, 2,*,† , Jahangir Abdi 2, * Yijun Yang 2,3 Hong Chang 4 1 Division of Molecular and Cellular Biology, Toronto General Research Institute, Toronto, Ontario, Canada 2 Department Laboratory Medicine & Pathobiology, University 3 Applied Chemistry, School Chemical Engineering Technology, Tianjin University, Tianjin, P. R. China Hematology Medical Oncology, Health Network, † Current address: Surgery, London Sciences Center, London, These authors have contributed equally to...
Cortical bone stem cell (CBSC) therapy after myocardial infarction alters the inflammatory response to cardiac injury. We found that cortical induces a unique macrophage phenotype in vitro and can modulate macrophage/fibroblast cross talk.