A5101733368- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Parvovirus B19 Infection Studies
- Coronary Artery Anomalies
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Platelet Disorders and Treatments
- Biochemical effects in animals
- CAR-T cell therapy research
- Cardiovascular Issues in Pregnancy
- Lymphoma Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Pregnancy and Medication Impact
- Cancer-related gene regulation
- Liver Disease and Transplantation
- Streptococcal Infections and Treatments
- Acute Myeloid Leukemia Research
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Ear Surgery and Otitis Media
Nanchang University
2015-2024
First Affiliated Hospital of Nanchang University
2015-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Capital Medical University
2021
Beijing Children’s Hospital
2008-2021
Qingdao University
1997
Hemophagocytic lymphohistiocytosis (HLH) is a relatively rare but life-threatening disease with confusing clinical manifestations, rapidly deteriorating health, high morbidity and mortality.To improve the recognition as well understanding of this disorder, we analyzed characteristics prognostic factors from 85 adult patients diagnosed HLH in our hospital April 2005 to June 2014.Patients displayed variable markers across wide spectrum. These included fever hyperferritinemia (100%), elevated...
Abstract Background Interleukin-10 (IL-10) is an independent factor for predicting adverse outcomes in pediatric patients with hemophagocytic lymphohistiocytosis (HLH). However, little known about its prognostic value adult patients. Methods This single center retrospective study was conducted to explore the of IL-10 101 adults newly diagnosed HLH. The serum interleukin levels were quantitatively determined by chemiluminescence using cytokine profiling kits. Results Serum significantly...
Background: Hemophagocytic lymphohistiocytosis (HLH) patients who need intensive care usually have multiple organ failure and poor prognosis. However, the clinical characteristics, therapeutic efficacy outcome in these critically ill HLH remained unclear. Methods: We performed a retrospective study of 50 from September 2013 to October 2022. Patients’ information was collected, overall survival rate estimated. Results: Fifty care, median sequential assessment (SOFA) score 8. 66.00% had septic...
Abstract Secondary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease. In the present retrospective study, we aimed to investigate coagulation disorders and their outcome implications in patients with secondary HLH. We evaluated clinical characteristics relationship between indices prognosis HLH ( n = 141). The information, including symptoms, laboratory indicators, indices, was evaluated. Coagulation bleeding events occurred 95 (67.4%) 60 (42.6%) patients, respectively....
Interleukin-10 (IL-10) has been suggested as a biomarker of disease activity in patients with adult-onset Still's (AOSD). In this study, we evaluated the serum IL-10 levels and investigated its clinical relevance systemic-onset juvenile idiopathic arthritis (SoJIA).IL-10 were determined 21 diagnosed SoJIA 35 fever diseases which suspected SoJIA, compared between regard to activity, courses, other biomarkers.Patients had significantly higher febrile diseases. The active inactive positively...
This study aimed to examine and summarize clinical characteristics of Kawasaki disease (KD) at different ages further strengthen clinicians understanding children with KD, improving the level diagnosis, reducing coronary artery complications KD. A total 398 patients KD who were diagnosed between January 2016 December 2017 reviewed retrospectively. These participants allocated into three groups according age: group (<1 year, n=62), B (≥1 <5 years, n=286), C (≥5 n=50). Clinical manifestations,...
Immunosuppressive therapy (IST) with horse or rabbit anti-human thymocyte immunoglobulin (h-/r-ATG) and hematopoietic stem cell transplantation (HSCT) are two baseline treatments for severe aplastic anemia (SAA) transfusion-dependent non-severe (TD-NSAA) patients. Addition of thrombopoietin receptor agonists (TPO-RAs) to standard IST has greatly improved the survival SAA, whereas porcine anti-lymphocyte globulin (p-ALG) combined TPO-RAs still had a matter debate.
To analyze the clinical characteristics and prognostic risk factors of adult patients with Epestein-Barr virus-associated hemophagocytic syndrome (EBV-HLH) so as to enhance understanding EBV-HLH diagnosis treatment level.The manifestation survival data 59 admitted in our hospital from January 2013 August 2018 were analyzed retrospectively.The most common manifestations high fever (100%), liver dysfunction (91.5%), however skin rashes (1.7%), neurologic abnormality (3.4%) rare. 96.6% showed...
To explore the amplification rate, clinical correlation and prognostic significance of 1q21 in newly diagnosed patients with multiple myeloma (MM).I-FISH was performed on purified 138+ plasma cells from 72 MM February 2013 to 2016 receiving bortezomib-based chemotherapy by using probe covered region. Cut off value is 20%. Amplification relevance were analysed patients.Among patients, male 52, femail 20, median age 58(33-80).The rate 45.8%, positivly correlated 13q14 deletion(P=0.041)and ISS...
Objective: To analyze the characteristics and prognosis of hearing loss in children with bacterial meningitis. Methods: This was a single-center retrospective cohort study. Patients diagnosed meningitis who were hospitalized Beijing Children's Hospital between 2010 2016 older than 28 days younger 18 years at symptom onset included this study (n=573). All clinical information including assessment results during hospitalization reviewed. patients followed up to repeat their test assess...
To retrospectively analyze clinical characteristics and survival time of patients with diffuse large B-cell lymphoma (DLBCL), detect prognosis-related markers, establish a nomogram prognostic model factors combined biomarkers.One hundred thirty-seven DLBCL were included in this study from January 2014 to March 2019 the First Affiliated Hospital Nanchang University. The expression GCET1, LMO2, BCL-6, BCL-2 MYC protein detected by immunohistochemistry (IHC), then influences these proteins on...
To evaluate the efficacy and safety of etoposide combined with cyclophosphamide (EC) regimen for mobilization autologous peripheral blood stem cells (APBSCs) in patients multiple myeloma (MM).The clinical data 48 MM who received APBSC transplantation (APBSCT) Department Hematology First Affiliated Hospital Nanchang University from January 2015 to October 2021 were retrospectively analyzed. The success rate optimal EC counted, its effect on transplant efficacy, adverse reactions,...
Results 42 patients were diagnosed MAS with SOJIA from 159 cases. The duration prior to is 11 months. High fever, hepatosplenomegaly, pancytopenia, liver dysfunction in all Bleeding was 12. 45% has had CNS dysfunction. 24% ARDS. 2 suffered renal damage. lab.tests revealed elevated live enzymes and ferritin, decreased value of ESR, album, CBC fibrinogen all. Bone marrow examination supported the diagnosis definite haemophagocytosis Lymph node biopsy done for one case found out it filled...