A5003692119- Leptospirosis research and findings
- Zoonotic diseases and public health
- Viral Infections and Vectors
- CRISPR and Genetic Engineering
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
Universidade Federal de Pelotas
2019-2021
Leptospirosis is a zoonosis that responsible for one million human cases per year. Fusing multiple immunogenic antigens represents promising approach to delivering an effective vaccine against leptospirosis. Mycobacterium bovis bacillus Calmette-Guérin (BCG) potential vector due its adjuvant properties and safety. Two chimeric genes based on genic sequences of ligANI, ligBrep, lipL32, lemA, were individually cloned into five BioBrick vectors with different promoters (pAN, Hsp60, 18 kDa,...
Abstract Leptospirosis is an emerging infectious disease caused by pathogenic Leptospira spp. A universal vaccine against leptospirosis likely to require highly conserved epitopes from leptospires, that are exposed on the bacterial surface, and generate a protective sterilizing immune response. Our group recently identified several genes predicted encode TonB-dependent receptors (TBDR) in interrogans using reverse vaccinology approach. Three leptospiral TBDRs were previously described...