A5089626479- Virus-based gene therapy research
- Probiotics and Fermented Foods
- COVID-19 diagnosis using AI
- Antimicrobial Peptides and Activities
- Animal Disease Management and Epidemiology
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Infection Control and Ventilation
- Dermatological and COVID-19 studies
- Salmonella and Campylobacter epidemiology
- Energy and Environment Impacts
- Artificial Intelligence in Healthcare and Education
- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Poxvirus research and outbreaks
- Immune Response and Inflammation
- CAR-T cell therapy research
- SARS-CoV-2 detection and testing
- T-cell and Retrovirus Studies
- RNA and protein synthesis mechanisms
- Mosquito-borne diseases and control
- Biomedical and Engineering Education
The Pirbright Institute
2019-2024
University of Surrey
2018-2023
Wellcome Sanger Institute
2014
Genomics (United Kingdom)
2014
Significance Common features have been observed in the genome sequences of bacterial pathogens that infect few hosts. These “host adaptations” include acquisition pathogenicity islands multiple genes involved disease, losses whole genes, and even single mutations affect gene function. Within Salmonella enterica is a natural model system four are each other’s closest relatives, including host-generalist, two host-specialists, one with strong host associations. With whole-genome sequences, we...
Abstract Rift Valley fever virus (RVFV) is a zoonotic mosquito-borne that was first discovered in Kenya 1930 and has since spread to become endemic much of Africa the Arabian Peninsula. (RVF) causes recurrent outbreaks febrile illness associated with high levels mortality poor outcomes during pregnancy—including foetal malformations, spontaneous abortion stillbirths—in livestock, miscarriage humans. No vaccines are available for human use those licensed veterinary have potential drawbacks,...
Abstract Probiotics are noninvasive, environmentally friendly alternatives for reducing infectious diseases in wildlife species. Our aim the present study was to evaluate potential of gut commensals such as lactic acid bacteria (LAB) probiotics. The LAB selected our analyses were isolated from European badgers ( Meles meles ), a reservoir bovine tuberculosis, and comprised four different genera: Enterococcu s, Weissella , Pediococcus Lactobacillus . enterococci displayed phenotype genotype...
Peste des petits ruminants (PPR) is a viral disease of small that caused by the PPR virus (PPRV) and significant burden on subsistence farmers across developing world. Loop-mediated isothermal amplification (LAMP) provides cost-effective, rapid, specific sensitive detection nucleic acid has been demonstrated to have field application for range viruses. We describe development novel PPRV RT-LAMP assay utilising carefully-selected primers (targeting N-gene) allowing all known lineages in < 20...
Adenovirus vectored vaccines have entered global use during the COVID-19 pandemic, and are in development for multiple other human veterinary applications. An attraction of technology is suitability storage at 2-8 °C months. Widely used vaccine ChAdOx1 nCoV-19 (University Oxford/AstraZeneca) based on a species E simian adenovirus. Species serotypes been wide range programs, but stability such vectors has not extensively described peer-reviewed literature. Here, we explore two candidate...
Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in UK. The European badger (Meles meles) important wildlife reservoir of bTB transmission to cattle, making eradication particularly difficult. In this respect, oral vaccination with attenuated M. vaccine Bacillus Calmette-Guerin (BCG) has been suggested as a wide-scale intervention reduce infection badgers. However, experimental studies show variable protection. Among...
Abstract A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV) has previously been shown to protect goats from challenge with wild-type PPRV at up 4 months post vaccination. Here, we present results a longer-term trial protection provided by such vaccine, challenging animals 6, 9, 12 and 15 Vaccinated developed high levels anti-PPRV protein antibodies, which were virus-neutralising, level these...
Introduction: Accurate and rapid diagnostics paired with effective tracking tracing systems are key to halting the spread of infectious diseases, limiting emergence new variants monitor vaccine efficacy. The current gold standard test (RT-qPCR) for COVID-19 is highly accurate sensitive, but time-consuming, requires expensive specialised, lab-based equipment. Methods: Herein, we report on development a SARS-CoV-2 (COVID-19) inexpensive diagnostic platform that relies reverse-transcription...
In an attempt to create novel methods reduce the transmission of SARS-CoV-2 and influenza viruses, fabric material was treated with Viruferrin™ tested for its inactivating properties against pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) A viruses. Inactivating were evaluated by comparing Viruferrin-treated cotton control without application saliva at various time points after virus exposure. statistically significant (p < 0.0001) decrease in number infectious...
Fabric material was coated with Viruferrin&trade; and tested for its inactivating properties against the pandemic severe acute respiratory syndrome 2 (SARS-CoV-2) influenza A viruses. statistically significant (p&lt;0.0001) decrease in number of infectious virus particles exposed to Viruferrin-treated fabric when compared cotton control both SARS-CoV-2 viruses observed. For A, fabrics experienced a &gt; 99% reduction without saliva after five minutes contact positive at time...