A5039539607- Migraine and Headache Studies
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Trigeminal Neuralgia and Treatments
- Psychosomatic Disorders and Their Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Prion Diseases and Protein Misfolding
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury Research
- Suicide and Self-Harm Studies
- Trace Elements in Health
- Cardiovascular Syncope and Autonomic Disorders
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Advanced Neuroimaging Techniques and Applications
- Myasthenia Gravis and Thymoma
- Moyamoya disease diagnosis and treatment
- Hereditary Neurological Disorders
- Toxin Mechanisms and Immunotoxins
- Frailty in Older Adults
- Down syndrome and intellectual disability research
- Body Image and Dysmorphia Studies
Kyoto Prefectural University of Medicine
2009-2024
Mayo Clinic Hospital
2021
Mayo Clinic in Florida
2021
WinnMed
2021
North Medical Center
2017-2019
Red Cross Hospital
2013
Krankenhaus vom Roten Kreuz
2013
Kyoto first Red Cross hospital
2010
Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An important problem in this lack sensitive, specific, noninvasive biochemical diagnosis to help clinical evaluation, monitoring progression, early differential from related diseases.To develop novel assay high sensitivity specificity detect small quantities αSyn aggregates circulating cerebrospinal fluid (CSF) patients affected by PD...
Abstract Objective To evaluate whether the 15‐day threshold of headache days per month adequately reflects substantial differences in disability across full spectrum migraine. Background The monthly frequency defines migraine subtypes and has crucial implications for epidemiological clinical research as well access to care. Methods patients with ( N = 836) who participated American Registry Migraine Research, which is a multicenter, longitudinal patient registry, between February 2016 March...
Alzheimer's disease (AD) is the most dominant neurodegenerative disorder that causes dementia, and no effective treatments are available. To study its pathogenesis develop therapeutics, animal models representing pathologies needed. Although many species senile plaques (SP) composed of amyloid-β (Aβ) proteins identical to those found in humans, none them exhibit neurofibrillary tangles (NFT) subsequent neurodegeneration, which integral parts pathology AD. The present shows Aβ accumulation,...
There is substantial biochemical, pathological, and genetic evidence that α-synuclein (A-syn) a principal molecule in the pathogenesis of Parkinson disease (PD). We previously reported total A-syn levels cerebrospinal fluid (CSF), measured with specific enzyme-linked immunosorbent assay (ELISA) developed by ourselves, were decreased patients PD, suggested usefulness CSF plasma as biomarker for diagnosis PD. After our report, considerable number studies have investigated blood, but...
Amyloid β-protein (Aβ42) oligomerization is an early event in Alzheimer's disease (AD). Current diagnostic methods using sequence-specific antibodies against less toxic fibrillar and monomeric Aβ42 run the risk of overdiagnosis. Hence, conformation-specific neurotoxic oligomers have garnered much attention for developing more accurate diagnostics. Antibody 24B3, highly specific conformer that has a turn at Glu22 Asp23, recognizes putative dimer, which forms stable potently than monomer. 24B3...
The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this have recently been identified families with multiple system atrophy (MSA). Moreover, specific heterozygous variants the also reported to confer susceptibility sporadic MSA Japanese cohorts. These findings suggested potential usefulness of CoQ10 as a blood-based biomarker diagnosing MSA. This study measured serum levels 18 patients MSA, 20 Parkinson's disease and control participants....
Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with pathology of Alzheimer's disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support diagnosis for DS, since positron emission tomography or cerebrospinal fluid sampling burdensome, particularly patients Plasma t-tau one established AD, suggesting potential value as a biomarker The aim this study was assess and compare plasma levels adults DS an age-matched control...
In June 2020, a large-scale food poisoning outbreak involving about 3000 elementary and junior high school students occurred in Yashio, Saitama, Japan. A lunch was the only stuff ingested by all of patients. Escherichia coli serotype O7:H4 carrying astA gene for enteroaggregative E. (EAggEC) heat-stable enterotoxin 1 (EAST1) detected faecal specimens from patients, sample inspection revealed its presence seaweed salad red (Gigartina tenella) as one raw materials. Analysis antibiotic...
Headache is one of the most common symptoms after concussion, and mild traumatic brain injury (mTBI) a risk factor for chronic migraine (CM). However, there remains paucity data regarding impact mTBI on migraine-related clinical course.Of 2161 patients who participated in American Registry Migraine Research between February 2016 March 2020, 1098 completed questions assessing history TBI (50.8%). Forty-four reported moderate to severe TBI, 413 mTBI. Patients' demographics, headache triggers,...
We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1 H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD). examined posterior cingulate gyri 228 subjects usin
Myasthenic symptoms can be present in patients with amyotrophic lateral sclerosis (ALS). These have been considered to caused by the degeneration of distal motor neurons and neuromuscular junction (NMJ). Recent studies suggested that antibody low-density lipoprotein receptor-related protein 4 (LRP4) was a pathogenic agent myasthenia gravis (MG), it also detected ALS patients. Patient 1: A 58-year-old Japanese man developed progressive weakness subsequent myasthenic including oculomotor...
Background Real-world data on the effectiveness and safety of lasmiditan, a new medication for acute migraine attacks, is necessary. Methods We performed prospective, observational, multi-center, real-world study. A total 48 patients with (44 females, 44.6 ± 12.9 years old) were included in this Results Twenty-three (47.9%) reported they headache-free two hours after taking lasmiditan categorized into responder group. In total, 44 (91.7%) experienced at least one side effect within...
Abstract Objective To explore hidden Markov models (HMMs) as an approach for defining clinically meaningful headache‐frequency‐based groups in migraine. Background Monthly headache frequency patients with migraine is known to vary over time. This variation has not been completely characterized and well accounted the classification of individuals having chronic or episodic migraine, a diagnosis potentially significant impacts on individual. study investigated reported population proposed...
Caffeine has been considered a neuroprotective agent against Parkinson's disease (PD). Recent metabolomic analysis showed that levels of caffeine and its metabolites were decreased in sera from patients with PD compared those healthy controls. We focused on theophylline, which is one the primary metabolites, as candidate biomarker because: (1) serum level can be measured hospital laboratories by standardized immunoassay kits for therapeutic drug monitoring (2) because it less markedly...
Objective This study aimed to describe the migraine burden and healthcare utilization in context of headache frequency using nationwide claims data linked online survey previously collected Japan. Background It has been shown that increase can impose greater impact on individuals’ daily social functioning, but those with low-frequency headaches remains largely unknown Methods post-hoc , observational reported 674 respondents who were working individuals their family members aged 19–74 years,...
A 66-year-old man was admitted for progressive proximal weakness and myalgia in his shoulder girdles without skin lesions. muscle biopsy showed infiltration of inflammatory cells, degeneration fibers, perifascicular atrophy. Remarkably, MHC-I antigen expressed the membrane most cells were CD8-positive, suggesting that class-I antigen-dependent cytotoxic T-cells played a crucial role pathology, which supported diagnosis polymyositis rather than dermatomyositis. Magnetic resonance imaging...
Intravenous immunoglobulin (IVIg) has been a candidate as potential anti-amyloid immunotherapy for Alzheimer disease (AD) because it contains β (Aβ) antibodies. Although several studies with IVIg in AD have published, changing levels of Aβ efflux from the brain, or disaggregation species induced by immunotherapy, not properly investigated. Here, we carried out an open label study therapy five patients AD. We collected plasma peripheral vein (peripheral-plasma) and internal jugular...
Two transferrin (Tf) glycan-isoforms were previously found in cerebrospinal fluid (CSF); one appears to be derived from serum (Tf-2) and the other choroid plexus, a CSF-producing tissue (Tf-1). To analyse metabolic differences associated with two isoforms, their ratio (Tf-2/Tf-1) was defined as Tf index. Here we report that indices of patients tauopathies including Alzheimer's disease (2.29 + 0.64) similar those neurological controls (2.07 0.87) (P = 0.147). In contrast, Parkinson's (PD,...
Abstract Objective To investigate the impact of having headaches prior to traumatic brain injury (TBI) on headache features and long‐term patient health outcomes. Background Methods This was an exploratory analysis patients with TBI who were enrolled in American Registry for Migraine Research (ARMR), a multicenter, prospective, longitudinal registry composed International Classification Headache Disorders, 3rd edition (ICHD‐3)–defined diagnoses. The ARMR study 2,707 between February 1, 2016...