A5053605824- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Flavonoids in Medical Research
- Immune Response and Inflammation
- Seed and Plant Biochemistry
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- Inflammasome and immune disorders
- Pregnancy and preeclampsia studies
- Dietary Effects on Health
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Plant-based Medicinal Research
- Reproductive Health and Contraception
- Ethnobotanical and Medicinal Plants Studies
- Indian History and Philosophy
- Library Science and Information Systems
- Meromorphic and Entire Functions
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Night-time city culture
- Magnolia and Illicium research
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
Chinese Academy of Agricultural Sciences
2024
Chengdu University
2019-2024
University of Macau
2024
Institute of Animal Science
2024
Chengdu University of Traditional Chinese Medicine
2016-2021
The evolution of Large Language Models (LLMs) like ChatGPT and GPT-4 has sparked discussions on the advent Artificial General Intelligence (AGI). However, replicating such advancements in open-source models been challenging. This paper introduces InternLM2, an LLM that outperforms its predecessors comprehensive evaluations across 6 dimensions 30 benchmarks, long-context modeling, open-ended subjective through innovative pre-training optimization techniques. process InternLM2 is meticulously...
Monitoring of the inhibition TNF-α, IL-6, iNOS and NO is used to effectively evaluate anti-inflammatory drugs. Baicalein was found have good activities, but its detailed cellular pharmacodynamic events not been expatiated by any other study. The inflammatory mediators, including production in RAW264.7 macrophage induced LPS, were measured. It that these data showed a sequential pattern on time based points model developed tested. TNF-α IL-6 quantified ELISA, detected Griess expression...
Pro-inflammatory factors are important indicators for assessing inflammation severity and drug efficacy. Coptisine has been reported to inhibit LPS-induced TNF-α NO production. In this study, we aim build a pharmacokinetic-pharmacodynamic model quantify the coptisine time course potency of its anti-inflammatory effect in LPS-stimulated rats. The plasma lung concentrations, concentration, iNOS expression were measured rats after intravenous injection three doses. disposition kinetics...
Golden buckwheat, also called
Negative energy balance (NEB) typically occurs in dairy cows after delivery. Cows with a high yield are more likely to experience significant NEB. This type of metabolic imbalance could cause ketosis, which is often accompanied by decline reproductive performance. However, the molecular mechanisms underlying NEB have yet be fully elucidated. During excessive NEB, body fat extensively broken down, resulting abnormal accumulation non-esterified fatty acids (NEFAs), represented palmitic acid...
Vanillin is a popular flavoring agent in the food, tobacco, and perfume industries. In this paper, we investigated effect of vanillin on transport rates drugs with different levels permeability (acyclovir, hydrochlorothiazide, propranolol carbamazepine) through Caco-2 cell bidirectional experiment. We also explored underlying mechanism using an silico technique fluorescence anisotropy measurements. The influence pharmacokinetics whose were affected by vitro was then studied vivo. Results...
The acute lung injury (ALI) mouse model induced by lipopolysaccharide (LPS) or endotoxin is still among the most commonly used models in animal studies of inflammation. current methods are an intraperitoneal injection LPS and tracheostomy for tracheal infusion LPS. However, former method lacks targeting damages other organs, latter induces operative trauma, infection risk, a low survival rate. Here, we recommend noninvasive oropharyngeal endotracheal intubation instillation mice. In this...
Context: Tsothel, a traditional Tibetan medicine, is regarded as ‘the king of essences’. Nevertheless, tsothel has aroused serious concern regarding its biosafety because main component HgS. Unfortunately, toxicological studies on are scarce.Objective: As inorganic mercury high affinity for the kidney, present investigation was designed to determine potential nephrotoxicity and mechanism tsothel.Materials methods: Sprague-Dawley rats were orally administered different doses (0, 66.70, 33.35...
While LLM-Based agents, which use external tools to solve complex problems, have made significant progress, benchmarking their ability is challenging, thereby hindering a clear understanding of limitations. In this paper, we propose an interactive evaluation framework, named CIBench, comprehensively assess LLMs' utilize code interpreters for data science tasks. Our framework includes dataset and two modes. The constructed using LLM-human cooperative approach simulates authentic workflow by...
<title>Abstract</title> Background: Negative energy balance (NEB) typically occurs in dairy cows after delivery, with those high yielding being more likely to experience significant NEB. Such metabolic imbalance could cause ketosis, which is often accompanied by a decline reproductive performance, but the molecular mechanism has not been fully elucidated. During excessive NEB, body fat extensively broken down, resulting abnormal accumulation of non-esterified fatty acids (NEFA), represented...