A5003258520- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- Amino Acid Enzymes and Metabolism
- 3D Printing in Biomedical Research
- Stress Responses and Cortisol
- Calcium signaling and nucleotide metabolism
- Fibroblast Growth Factor Research
- Protease and Inhibitor Mechanisms
- Tendon Structure and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Polysaccharides and Plant Cell Walls
- GDF15 and Related Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Polyamine Metabolism and Applications
- Neuroscience and Neuropharmacology Research
- Geophysics and Gravity Measurements
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Xenotransplantation and immune response
- Sulfur Compounds in Biology
- Proteoglycans and glycosaminoglycans research
- Pancreatic function and diabetes
- Animal health and immunology
- Cellular Mechanics and Interactions
- Metabolism, Diabetes, and Cancer
University of Oklahoma Health Sciences Center
2012-2020
University of Louisville
2014
Osaka University of Health and Sport Sciences
2013
Aichi Medical University
1995
University of Washington
1995
Rockefeller University
1967
The pinocytosis-inducing effect of a number molecular species was studied in cultures mouse macrophages. Agents were added to basal medium containing 1% NBCS-No. 199 and allowed interact with cells for 150 min. Vesicle counts then performed compared control the medium. Certain proteins, i.e. albumin fetuin, isoelectric points five below found be potent stimulators vesicle formation. Basic proteins including lysozyme, histone, protamine had little influence at sublethal concentrations....
A decline in mitochondrial function and biogenesis as well increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction circulating levels insulin-like growth factor-1 (IGF-1) that closely associated with neuronal aging neurodegeneration. In this study, we investigated the effect IGF-1 signaling age on astrocyte metabolism its association learning memory.Learning memory was assessed using radial arm water maze young old...
A study has been conducted on the influence of nucleosides and nucleotides to induce formation pinocytic vesicles in cultured mouse macrophages. Extremely high levels cytoplasmic were found after exposure macrophages adenosine 5'-phosphate, ADP, ATP. limited vesicle response was obtained with 2'-. 3'-phosphate, 3',5'-adenosine-phosphate, deoxyadenosine 5'-phosphate. The di- triphosphates guanosine, inosine, cytidine, uridine stimulatory but much less active than derivatives. Adenosine...
Bovine sera contain factors which are capable of agglutinating mouse erythrocytes and stimulating the pinocytic activity cultivated macrophages. The hemagglutinating vesicle-inducing activities increase with age animal absent in fetal calf serum. majority this material is recovered globulin fractions prepared Na2SO4-(NH4)2SO4 bovine fraction II. It behaves as a macroglobulin studies employing zone electrophoresis, Sephadex G-200 filtration, sucrose density gradient centrifugation, its...
Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute cognitive decline, but the overall etiology remains unknown. Here, we hypothesized dysfunction mediated, in part, by increased levels inflammatory cytokines alter allopregnanolone (AlloP) levels, an important neurosteroid brain. We assessed and regulation AlloP effects supplementation on function 4-month-old 24-month-old male C57BL/6 mice. With age, expression...
Human γ-glutamyltranspeptidase 1 (hGGT1) is a cell-surface enzyme that regulator of redox adaptation and drug resistance due to its glutathionase activity. The human GGT2 gene encodes protein 94% identical the amino-acid sequence hGGT1. Transcriptional profiling analyses in series recent publications have implicated hGGT2 as modulator disease processes. However, has never been shown encode with enzymatic aim this study was express encoded by each known variants assess their stability,...
Cell migration is fundamental to many biological processes, including development, normal tissue remodeling, wound healing, and pathologies. However, cell a complex process, understanding its regulation in health disease requires the ability manipulate measure this process quantitatively under controlled conditions. This report describes simple vitro assay for quantitative analysis of two-dimensional cultures that an inexpensive alternative classic "scratch" assay. The method described...