A5056756985- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Virus-based gene therapy research
- Lung Cancer Research Studies
- Immune cells in cancer
- CAR-T cell therapy research
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- HIV Research and Treatment
- T-cell and B-cell Immunology
Baylor College of Medicine
2024-2025
Michigan State University
2018-2021
Abstract T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent immune system. Although repetitive, cognate TCR signaling is recognized as primary driving force behind this phenomenon, and it remains unknown what other forces drive in tumor microenvironment (TME). In study, we show that activation self-ligand SLAMF7 receptor on cells induced STAT1 STAT3 phosphorylation, expression multiple inhibitory receptors, transcription factors associated with...
For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined cisplatin nearly universally results in death. Although hyperactivation the Nrf2 pathway can drive resistance along suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary synergistic lethality other oncogenic drivers (e.g., NOTCH1 mutations). We evaluated efficacy PI3K inhibitors (PI3Ki) bypassing Nrf2-mediated HNSCC....
Abstract Current advances in combined antiretroviral therapy have rendered HIV infection a chronic, manageable disease; however, the problem of persistent immune activation still remains despite treatment. The cell receptor SLAMF7 has been shown to be upregulated diseases characterized by chronic activation. In this study, we studied function cells patients and impacts signaling on peripheral We observed increased frequencies SLAMF7+ PBMCs HIV+ individuals clinical phenotype-dependent...
Targeted modulation of the immune system against tumors can achieve responses in otherwise refractory cancers, which has spurred efforts aimed at optimizing such strategies. To this end, we have previously investigated cancer immunotherapy approaches using recombinant adenovirus vectors, as well via self-ligand receptor SLAMF7. Here, present a gene transfer-based approach targeted expression SLAMF7-Fc fusion construct directly into high concentrations adenoviral vector (Ad-SF7-Fc). Using...
Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate responses contribute escape from immune surveillance. Given the variety of involved in shielding tumors recognition, it is not surprising single-agent approaches have been largely unsuccessful generating durable antitumor responses. Here we report a unique combination cytostatic agents recondition tumor microenvironment...
T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent immune system. While tonic receptor (TCR) signaling is recognized as primary driving force behind this phenomenon, it still unknown what other forces drive in tumor microenvironment. Here, using a combination human vitro and murine vivo systems, we show that, independent TCR signaling, self-ligand SLAMF7 drives expression both inhibitory receptors exhaustion-promoting transcription factors. can be...