A5078039612- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Poxvirus research and outbreaks
- CAR-T cell therapy research
- Xenotransplantation and immune response
- MicroRNA in disease regulation
- Microbial infections and disease research
- Syphilis Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Virus-based gene therapy research
- Immune cells in cancer
- Foreign Body Medical Cases
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Mycotoxins in Agriculture and Food
Karolinska Institutet
2015-2021
Svenska Örtmedicinska Institute
2018
Karolinska University Hospital
2016-2017
Northwick Park Hospital
1995
Salisbury University
1962-1977
University of Birmingham
1975-1977
Abstract Treatment of cancer patients by adoptive T cell therapy has yielded promising results. In solid tumors, however, cells encounter a hostile environment, in particular with increased inflammatory activity as hallmark the tumor milieu that goes along abundant reactive oxygen species (ROS) substantially impair antitumor activity. We present strategy to render more resilient toward ROS coexpressing catalase specific chimeric Ag receptor (CAR) increase their antioxidative capacity...
Perforated plastic chambers implanted subcutaneously in guinea-pigs and rabbits became encapsulated filled with sterile transudate. When these were inoculated various strans of Neisseria gonorrhoeae, persistent infections achieved without the use anti-inflammation agents presence a substantial predominantly polymorphonuclear inflammatory response. Two strains small colonies similar to types 1 2, one strain large type 4 Kellogg et al. (1963 1968), showed differences infectivity comparable...
SUMMARY: Gonococci (strain BS3) passaged three times and harvested directly from plastic chambers implanted subcutaneously in guinea pigs were compared with the parent strain (BS) grown vitro. The vivo produced smaller colonies than that vitro when examined chamber fluid was sometimes not pilated. It more resistant to bactericidal action of human serum infective for guinea-pig chambers. In gel diffusion, extracts organisms adapted cultured once on agar appeared contain one or two antigens...
There is an urgent need for new treatment options in metastatic drug-resistant prostate cancer. Combining immunotherapy with other targeted therapies may be effective strategy advanced In the present study, we sought to investigate enhance efficacy of anti-CTLA-4 therapy against cancer by combination STAT3 inhibition.Male C57BL6 mice were subcutaneously inoculated murine cell line RM-1. Tumor progression was monitored following vehicle, small molecule inhibitor GPB730, or GPB730 +...
Phagocytes obtained from fresh human buffy coat (predominantly polymorphonuclear phagocytes) or which had been incubated on a glass surface for 1 to 3 days mononuclear were allowed ingest gonococci, and then with penicillin. More intracellular gonococci killed at high than low penicillin concentrations, indicating that penetrated the phagocytes. This was supported by autoradiography experiments radiolabelled A pilated, small-colony-forming gonococcal strain survived multiplied least 15 h in...
Abstract Metastatic breast cancer is a fatal disease that responds poorly to treatment. Cancer vaccines targeting antigens expressed by metastatic cells and stem could function as anticancer therapies. Cripto-1 an oncofetal protein overexpressed in invasive cancer-initiating cells. In this study, we explored the potential of Cripto-1–encoding DNA vaccine target preclinical mouse models. BALB/c mice BALB-neuT were treated with encoding (mCr-1). challenged murine 4T1 or TUBO spheres;...
Attempts to study quantitatively the phagocytosis of gonococci from urethral pus failed because small numbers organisms and technical difficulties. However, chambers implanted subcutaneously in guinea pigs, which were similar their resistance killing by human serum, obtained sufficient quantities for comparison tests with vitro grown strains they derived. Microscopic viable counts phagocytes showed that vivo (strain BSV) readily phagocytosed polymorphonuclear phagocytes. There was little...
Regulatory T cells (Treg) suppress anti-tumor immune responses and their infiltration in the tumor microenvironment is associated with inferior prognosis cancer patients. Thus, order to enhance responses, selective depletion of Treg highly desired. We found that treatment zoledronic acid (ZA) resulted a decrease frequency was significant increase proliferation natural killer (NK) peripheral blood patients metastatic cancer. In vitro, genome-wide transcriptomic analysis revealed alterations...
Metastatic melanoma is a fatal disease that responds poorly to classical treatments but can be targeted by T cell-based immunotherapy. Cancer vaccines have the potential generate long-lasting cytotoxic CD8+ cell responses able eradicate established and disseminated tumors. Vaccination against antigens expressed tumor cells with enhanced metastatic represents highly attractive strategy efficiently target deadly disease. Cripto-1 frequently over-expressed in human carcinomas melanomas, only at...
Summary In tests in vitro with the phagocytes of human buffy coat, a recent isolate Neisseria gonorrhoeae, which was pilated, formed small colonies and resembled virulent Kellogg type 2 (strain BS), resisted ingestion more than did another AL), non-pilated, large avirulent 4. Some members both strains survived for significant periods within test conditions that tended to minimise rather maximise such survival; strain BS had greater capacity intracellular survival AL, some its surviving at...
### O1 IL-15 primes an mTOR-regulated gene-expression program to prolong anti-tumor capacity of human natural killer cells #### Andreas Lundqvist1, Vincent van Hoef1, Xiaonan Zhang1, Erik Wennerberg2, Julie Lorent1, Kristina Witt1, Laia Masvidal Sanz1, Shuo Liang1, Shannon Murray3, Ola Larsson1,
S ummary . The incorporation of erythritol (1 μ M /ml) in Morris medium caused the earlier appearance colonies virulent strains Brucella abortus and B. melitensis. On Albimi agar accelerated growth melitensis but not that abortus. There was no acceleration a strain suis on either medium.