A5089394240- Cancer Treatment and Pharmacology
- Pharmacogenetics and Drug Metabolism
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Chemotherapy-induced organ toxicity mitigation
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Neutropenia and Cancer Infections
- Chemotherapy-induced cardiotoxicity and mitigation
- Hemophilia Treatment and Research
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Cancer Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects and Toxicity Studies
Karolinska Institutet
2002-2023
Shanghai Jiao Tong University
2023
Renji Hospital
2023
Fujian Medical University
2023
Oncopeptides (Sweden)
2021
Saint Göran Hospital
2018-2020
Karolinska University Hospital
2002-2018
Regulatory T cells (Treg) suppress anti-tumor immune responses and their infiltration in the tumor microenvironment is associated with inferior prognosis cancer patients. Thus, order to enhance responses, selective depletion of Treg highly desired. We found that treatment zoledronic acid (ZA) resulted a decrease frequency was significant increase proliferation natural killer (NK) peripheral blood patients metastatic cancer. In vitro, genome-wide transcriptomic analysis revealed alterations...
Previous studies on CYP2D6 activity and the effect of adjuvant tamoxifen in breast cancer are inconsistent. We analyzed impact polymorphism pre- post-menopausal patients that were adherent to treatment for at least a year.A total 382 prescribed 5 years constituted study-base. Clinical information, including compliance outcome, was retrieved from medical records. Comprehensive genotyping performed translated into predicted metabolic activity.In one year (n = 313) there an association between...
Aim: This study aimed to investigate the effect of CYP3A4 and CYP3A5 genotypes on clinical outcomes docetaxel treatment. Patients & methods: In PROMIX trial, 150 breast cancer patients received preoperatively. genotype combinations were transformed into total CYP 3A phenotypes. Results: Seven characterized as poor metabolizer (PM), 22 extensive 121 intermediate metabolizer. The frequency grade 3/grade 4 adverse events was higher in PM group (p = 0.002). One subject who basically lacked...
The feasibility of longitudinal metastatic biopsies for gene expression profiling in breast cancer is unexplored. Dynamic changes can potentially predict efficacy targeted drugs. Patients enrolled a phase III trial with docetaxel monotherapy versus combination + sunitinib were offered to participate translational substudy comprising fine needle aspiration and Positron Emission Tomography imaging before (T1) two weeks after start treatment (T2). Aspirated tumor material was used microarray...
Aim: We investigated the interaction of CYP2C19 and CYP2D6 genotype on clinical outcome in tamoxifen-treated breast cancer patients. Materials & methods: A cohort 306 patients tamoxifen treatment for a minimum 1 year were employed to analyze effect genotype-predicted phenotype relapse-free survival. Results conclusion: show that group with worst highest risk relapse is 2C19↑–2D6↓ (hazard ratio: 2.94), when adjusting age, Nottingham prognostic index adjuvant chemotherapy. Furthermore,...
Abstract Supernumerary teeth are advantaged sources for high‐quality stem cell preparation from both apical papilla (SCAP‐Ss) and dental pulp (DPSCs). However, the deficiency of systematic detailed comparison biological transcriptomic characteristics aforementioned cells largely hinders their application in regenerative medicine. Herein, we collected supernumerary SCAP‐S DPSC isolation identification by utilizing multiple tests (e.g., growth curve, cycle apoptosis, adipogenic osteogenic...
Abstract: Cyclophosphamide (CPA) is widely used in chemotherapy. The CPA a prodrug that requires metabolic transformation to generate the active metabolite, 4‐hydroxy‐CPA (4‐OH‐CPA). Ciprofloxacin (CF) fluoroquinolone antibiotic with broad spectrum commonly treatment of variety infections. It has been reported prophylactic administration CF during conditioning was high‐risk factor for relapse patients undergoing allogeneic bone marrow transplantation. In present study we investigated...
Use of the patient's body surface area (mg m−2) as a basis for dosing does not take individual variation in metabolic capacity and rate clearance into account. Here, we evaluated novel approach monitoring short-lived cytotoxic agents formed from cytostatic drugs such cyclophosphamide (CP). The accumulated blood dose active agent phosphoramide mustard (PAM) CP was measured reaction product with hemoglobin (Hb adduct). This adduct, N-[2-(2-oxazolidonyl)ethyl]-valyl Hb (OzVal-Hb), detached...
Photo-recall phenomenon is a rarely recognized adverse event of chemotherapeutic agents. The physiopathology this entity unclear. We have reported 56-year old breast cancer patient with severe photo toxicity recalled 5 months after the initial sunburn by one course adjuvant docetaxel treatment. However, being given right diagnosis and proper managements could be able to complete her chemotherapy according planed time schedule, without any delay. Our case may explained theory that long-lived...
<h3>Background</h3> Adoptive T cell therapy utilizing high-precision neoantigen targeting is a promising concept for the treatment of solid tumors. Personalized tumor trained lymphocytes (pTTL) an autologous product originating from regional lymph nodes (RLN) and patient-specific neoantigens. A phase I/II First in Human (FIH) clinical trial pTTL Stage IV colorectal cancer (CRC) patients ongoing. Methods produced through <i>in vitro</i> expansion cells derived tumor-adjacent RLNs. The are...
e22120 Background: Classical histopathological markers usually determined in the primary tumor are used for therapy selection and prognostication metastatic breast cancer. Data on prognostic or predictive value of gene expression profiling metastases limited. Methods: Patients enrolled a phase III trial cancer with docetaxel monotherapy versus combination + sunitinib were offered to participate translational substudy comprising sequential fine needle aspiration biopsies Positron Emission...
1067 Background: Marked inter-individual variability of docetaxel has been reported previously. The pharmacogenetic contribution to variations docetaxel-related toxicity and therapeutic response not yet thoroughly studied. polymorphic cytochrome P450 (CYP) 3A4 plays en essential role in the metabolism docetaxel. A comparatively frequent allele - CYP3A4*22, which was recently identified, shown correlate with reduced enzyme activity. In this study, we aimed investigate effect CYP3A4 as well...
<h3>Background</h3> The new generation of adoptive T cell therapy utilizing high-precision neoantigen targeting is gaining increasing interest, especially in solid tumors, where the unmet medical need high. Personalized tumor trained lymphocytes (pTTL) a novel autologous patient-specific neoantigens. A phase I/IIa First Human (FIH) clinical trial pTTL Stage IV colorectal cancer (CRC) patients has started 2023. <h3>Methods</h3> produced through <i>in vitro</i> expansion cells derived from...