A5047733931- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Economic and Financial Impacts of Cancer
- Renal and related cancers
- Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Colorectal and Anal Carcinomas
- Nutrition and Health in Aging
- Sexual Differentiation and Disorders
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- Women's cancer prevention and management
- Lung Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Advances in Oncology and Radiotherapy
Eastern Cooperative Oncology Group
2024
AC Camargo Hospital
2014-2023
City Of Hope National Medical Center
2017
City of Hope
2017
Universidade Estadual de Campinas (UNICAMP)
2009
Circulating tumor cells are important markers of progression and can reflect behavior in metastatic colorectal cancer (mCRC). Identification proteins that confer resistance to treatment is an step predict response better selection for patients. Multidrug resistance-associated protein 1 (MRP1) 4 (MRP4) play a role irinotecan-resistance, Excision Repair Cross-Complementation group (ERCC1) expression platinum compounds. Here, we included 34 patients with mCRC most them received FOLFIRI or...
Cancer is primarily a disease in which late diagnosis linked to poor prognosis, and unfortunately, detection management are still challenging. Circulating tumor cells (CTCs) potential resource address this disease. Cell fusion, an event discovered recently CTCs expressing carcinoma leukocyte markers, occurs when ≥2 become single entity (hybrid cell) after the merging of their plasma membranes. fusion poorly understood despite continuous evaluations vitro/in vivo studies. Blood samples from...
Colorectal cancer is a common and often deadly cancer. Circulating tumor cells (CTCs) have been implicated as potentially valuable prognosis factor. The detection of circulating microemboli (CTM) simple blood component parameters that reflect inflammatory status, such the platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte (NLR), may provide information about progression. aim this study was to explore importance CTCs, CTM, PLR, NLR prospectively in non-metastatic colon CTCs were...
Although multiple therapies have emerged for the treatment of metastatic renal cell carcinoma (mRCC), it is unclear whether application these agents consistent in developed and developing countries. We sought to determine patterns care mRCC Brazil as a representative country.A commercial database was used acquire information pertaining patients with receiving at private or public hospitals between March 2013 October 2016. Basic clinical demographic criteria were available, well ascertain...
The discovery of predictive biomarkers in metastatic colorectal cancer (mCRC) is essential to improve clinical outcomes. Recent data suggest a potential role circulating tumor cells (CTCs) as prognostic indicators. We conducted follow-on analysis from prospective study consecutive patients with mCRC. CTC was at two timepoints: baseline (CTC1; before starting chemotherapy), and months after treatment (CTC2). isolation/quantification were completed by ISET® (Rarecells, France). expressions...
Desmoid tumor (DT) is a rare neoplasm with high local recurrence rates, composed of fibroblastic cells that are characterized by the expression key molecules, including intermediate filament vimentin, cyclooxygenase-2 (COX-2), and nuclear β-catenin, lack epithelial markers. Circulating (CTCs) isolated from peripheral blood patients sarcomas other neoplasms can be used as early biomarkers invasion dissemination. Moreover, CTCs also re-colonize their tumors origin through process "tumor...
Circulating tumor cells (CTCs) play an important role in progression and metastasis, particularly form of cluster, which is called circulating microemboli (CTM), can be found the peripheral blood cancer patients. The aim this study was to evaluate presence CTCs CTM, its influence on lung were isolated by Isolation Size Epithelial Tumor (ISET®) Technology. samples metastatic patients collected before beginning systemic chemotherapy. CTM identified according their morphological features....
203 Background: Colorectal cancer (CRC) is one of the most common worldwide. Around 30% present metastatic disease at diagnosis and 50%–60% patients develop metastasis. New prognostic markers are needed circulating tumor cells (CTCs) a promising tool. Methods: Prospective study conducted by blood collection from 75 (pts) with CRC (mCRC), twice, 2 months interval, together image exams for therapeutic response evaluation. CTCs were detected ISET identified immunocytochemistry. Results: The...
5588 Background: Interval debulking surgery (IDS) is an option to treat patients with stage IIIC and IV ovarian carcinoma. Two randomized trials have shown similar survival for primary sugery (PDS) IDS. One of the concerns IDS potentialy higher risk induce platinum resistance when treating larger disease volume. At least one retrospective analysis sugest that treated a develop at second relapse. Methods: We did retroscpective review medical records from 213 carcinoma single institution 2000...
Abstract Purpose Renal cell carcinoma is an aggressive disease with a high mortality rate. Management has drastically changed the new era of immunotherapy, and novel strategies are being developed; however, identifying systemic treatments still challenging. This paper presents update expert panel consensus from Latin American Cooperative Oncology Group Cancer on advanced renal management in Brazil. Methods A 34 oncologists experts discussed voted best options for managing Brazil, including...
9549 Background: Ageing is a global phenomenon, also in Brazil. That shift demographics has huge impact healthcare. Although still emerging developing nations, there no major national innitiative focusing on oncologic geriatric pts. The study describes program to improve care >70y cancer pts A C Camargo Cancer Center, Sao Paulo. We hypothesized that incorporating CGA into daily practice can individualized care. Methods: aims of the were evaluate if: 1) could be feasible practice, 2) it...
525 Background: TKI have improved the prognosis of patients with mRCC, but rarely lead to durable response. Predictive clinical biomarkers been studied in last few years, most are still controversial. Objective: Identify role and laboratorial outcome mRCC. Methods: A retrospective study mRCC treated VEGFR-TKi first line at C Camargo Cancer Center (Jan-07 Apr-16). Studied biomarkers: induced hypertension (HTN), acquiried hypothyroidism, proteinuria, neutrophil lymphocyte ratio (NLR). Data...
e22020 Background: The presence of circulating tumor cells (CTCs) is a necessary process for cancer progression. In fact, its detection has surged as potential biomarker clinical response in treatment patients with non-small cell lung (NSCLC). This study analyzed level CTCs and outcome, well expression genes related to drug resistance. Methods: Consecutive single institution stage I-IV NSCLC were included. Isolation, counting characterization made by ISET (Isolation Size Epithelial Tumors;...
e21522 Background: Education in GO is of extreme importance, due to epidemiology and since aging a important risk factor for cancer. The oncology community has deal with how educate the workforce load patients future. Meetings/M are good broadcast elderly (E) treatment education. However, was an area interest only 1% ASCO Annual m attendees 2014-5 (http://am.asco.org/attendee-demographics), turning some thoughts needed about improving assistance, research teaching. Methods: Data collection...
e22036 Background: CTCs have demonstrated promising results as a prognostic tool in patients with mCCR. The purpose of our study was to prospectively correlate counting clinical outcomes and therapeutic responses accessed by conventional imaging. We also aimed evaluate bevacizumab use the KRAS status their correlation kinetics over time. Methods: A prospective 54 mCRC. Blood samples were collected at baseline two follow-up visits every months. used ISET system (Isolation Size Epithelial...
704 Background: Treatment of advanced clear cell renal carcinoma (ccRCC) improved dramatically in the last 20 years, but biomarkers development lagged behind. Circulating tumor (CTC) is used as a prognostic and predictive tool many solid tumors poorly studied ccRCC. Objective: Our aim was to evaluate CTC counts serial blood samples from patients with ccRCC that started first-line treatment analyze protein expression PBRM1, BAP1, PD-L1 CD133 these cells. Methods: Blood (10mL) were collected...
1 Background: Adrenocortical carcinoma (ACC) is a rare (1,02 per million population) disease with unfavorable prognosis. In Brazil, the incidence about 15 times higher than in rest of world, mainly due to significant prevalence TP53-R337H germline mutation this population. Methods: We performed retrospective analysis 66 patients diagnosed ACC at AC Camargo Cancer Center. Clinical, pathological, epidemiological, treatment and survival data were collected from patient’s chart described....
e24059 Background: Analysis of Circulating tumor cells (CTCs) seems to be promising for detection, monitoring, and survival prediction rectal carcinoma (RC). Thymidylate synthase (TYMS) enzyme acts in the 5-Fluorouracil (5-FU) metabolism, when overexpressed, can confer resistance this drug. 5-FU, a potent radiossensitizer, is routinely used neoadjuvant chemoradiation therapy (CRT) locally advanced RC (LARC). We evaluate TYMS messenger RNA (mRNA) expression CTCs isolated from patients (pts)...
Abstract Introduction: Desmoid tumor (DT) is a rare neoplasm with high local recurrence rates. CTNNB1 mutations are found in most sporadic cases and located exon 3, usually codons 41 or 45 (p.T41A, p.S45F p.S45P). Circulating cells (CTCs) isolated from the peripheral blood of patients sarcomas other neoplasms can be early biomarkers invasion dissemination. Moreover, CTCs also re-colonize their tumors origin through process “tumor self-seeding.” Objectives: To identify DT; to evaluate...