A5102752904- Synthesis of Organic Compounds
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Radical Photochemical Reactions
- Synthesis of Indole Derivatives
- Stroke Rehabilitation and Recovery
- Spine and Intervertebral Disc Pathology
- Climate Change and Health Impacts
- Cardiac and Coronary Surgery Techniques
- Spinal Cord Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Synthesis and Biological Evaluation
- Thermoregulation and physiological responses
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Spinal Fractures and Fixation Techniques
- Gut microbiota and health
- Metal complexes synthesis and properties
- Organoselenium and organotellurium chemistry
- Trace Elements in Health
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Infrared Thermography in Medicine
- Cardiac Ischemia and Reperfusion
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Beijing Sport University
2023
Jiangsu Province Hospital
2020-2023
University of South China
2023
Nanjing University of Chinese Medicine
2023
Jiangsu Normal University
2016-2022
General Hospital of Central Theater Command
2022
Nanjing Medical University
2020-2021
A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction oxygen-containing 1,7-enynes with thiosulfonates has been developed. The shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, were well driven achieve bifunctionalization oxo-1,7-enynes which derived from aliphatic alkynes. In addition, (E)-configuration products was highly controlled...
A novel and efficient electrochemical radical δ-H sulfonylation reaction of para-quinone methides (p-QMs) sodium sulfinates has been achieved under common laboratory conditions. In this strategy, a new C(sp2)–S bond was constructed for the synthesis 4-((aryl,arylsulfonyl)methylene)-2,5-cyclohexadiene derivatives with broad substrate scope, good functional group tolerance, mild Further studies showed that had an excellent regional selectivity.
A novel and facile methodology for the synthesis of sulfonated benzo[b]oxepinone chromane derivatives was reported by reaction propargyl chalcones with arylsulfonyl chloride via radical cascade annulation/sulfonation under laboratory conditions. Readily available chalcones, commercialized chloride, simple conditions make this six(seven)-membered oxygen-containing heterocycles' synthetic strategy more attractive significant application values.
An efficient and green reactions of isatins, 3‐amine‐1 H ‐pyrazole (5‐methyl‐1 ‐pyrazol‐3‐amine) 1,3‐diketone in aqueous medium for the synthesis novel 1′,7′,8′,9′‐tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]quinoline]‐2,5′(6′ )‐dione derivatives were reported this research. The advantages reaction are simple operation, mild‐reaction conditions, wide scope substrate, high yields, friendly environment. products confirmed by IR, 1 NMR, 13 C HRMS.
An efficient and facile synthesis of 3-(5-aryl-1,3-dimethyl-2-oxo-2,3-dihydro-1<i>H</i>-imidazol-4-yl)indolin-2-one 3-(2,5-diaryl-3-oxo-1,2,3,6-tetrahydropyrrolo[2,3-<i>c</i>]pyrazol-4-yl)indolin-2-one derivatives is reported from the selective cyclization reaction 3-(2-aryl-2-oxoethylidene)indolin-2-one 1,3-dimethylurea or 5-amino-2-phenyl-2,4-dihydro-3<i>H</i>-pyrazol-3-one under Brønsted acid conditions. Although there are two carbonyl groups in substrate, group out isatin specially...
Objectives. Functional prognosis is potentially correlated with gut microbiota alterations following the dysregulation of gut-microbiota-brain axis after stroke. This study was designed to explore poststroke and potential correlations between global functions. Methods. A total thirty-eight patients stroke thirty-five healthy demographics-matched controls were recruited. Their fecal DNAs extracted, V3-V4 regions conserved bacterial 16S RNA amplified sequenced on Illumina MiSeq platform....
The newly developed monoplanar pedicle screws (MPPSs) can mobile in axial plane but fixed the sagittal plane, which holds potential to combine ease of rod placement with strength theoretically. So far, few clinical studies focused on outcomes MPPSs for treatment thoracolumbar fractures (TLFs). aim this study was compare efficacy polyaxial (PAPSs) percutaneous intermediate fixation TLFs.Seventy-eight patients who sustained TLFs without neurological deficits and underwent using (40 patients)...
Rationale: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors enable an additional 54–75% reduction in low-density lipoprotein cholesterol (LDL-C) statin-treated patients, demonstrating plaque regression coronary artery disease. However, the impact of achieving extremely low level LDL-C with PCSK9 (e.g. Evolocumab) on symptomatic intracranial atherosclerosis remains unexplored. Aim and hypothesis: To determine whether combining Evolocumab statins achieves a more significant...
The reactions of isatins, urea and 1‐(piperidin‐1‐yl)butane‐1,3‐dione or 1‐morpholinobutane‐1,3‐dione have been developed for the preparation spiroheterocycles compounds. It was found these could be given higher yields required shorter time in our process. In this synthesis, some useful groups, such as pyridyl morpholinyl were introduced into structures products. compounds confirmed by IR, 1 H NMR, 13 C HRMS. Else, 4i 4r additionally X‐ray diffraction analysis. other advantages procure...